| Project/Area Number |
24592676
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Ueda Tetsuo 奈良県立医科大学, 医学部, 講師 (00364068)
Annaka Masahiko 九州大学, 理学研究院, 教授 (40282446)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ハイドロゲル / レンズリフィリング / 調節力 / レンズリフィル / Lens refilling / レンズフィル / 感温性ハイドロゲル / 人工水晶体 |
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| Outline of Final Research Achievements |
We performed lens re-filling in primates (Macaca fascicularis) who had structure of the accommodation system same as a human being and was able to evaluate accommodation with a shape changes of the crystalline lens objectively. Silicone oil and silicon gel using in lens re-filling are previously reported. The report using the hydrogel in this procedure is for the first time. We investigated intracapsular quantity of infusion, the shape of the lens capsule and adjustment of the quantity of refraction, and degree of the after-cataract, obtained good results. Although it is necessary for long-term observation, nanocomposite gel is a good candidate for lens refilling material. And we were able to confirm the possibility of the clinical application in near future.
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