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Evaluation of accommodation after hydrogel lens refilling

Research Project

Project/Area Number 24592676
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionNara Medical University

Principal Investigator

Matsuura Toyoaki  奈良県立医科大学, 医学部, その他 (10238959)

Co-Investigator(Kenkyū-buntansha) Ueda Tetsuo  奈良県立医科大学, 医学部, 講師 (00364068)
Annaka Masahiko  九州大学, 理学研究院, 教授 (40282446)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsハイドロゲル / レンズリフィリング / 調節力 / レンズリフィル / Lens refilling / レンズフィル / 感温性ハイドロゲル / 人工水晶体
Outline of Final Research Achievements

We performed lens re-filling in primates (Macaca fascicularis) who had structure of the accommodation system same as a human being and was able to evaluate accommodation with a shape changes of the crystalline lens objectively. Silicone oil and silicon gel using in lens re-filling are previously reported. The report using the hydrogel in this procedure is for the first time. We investigated intracapsular quantity of infusion, the shape of the lens capsule and adjustment of the quantity of refraction, and degree of the after-cataract, obtained good results. Although it is necessary for long-term observation, nanocomposite gel is a good candidate for lens refilling material. And we were able to confirm the possibility of the clinical application in near future.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (19 results)

All 2016 2015 2014 2013 2012 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 3 results) Presentation (8 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Book (1 results) Remarks (2 results)

  • [Journal Article] 白内障手術の進歩2016

    • Author(s)
      松浦豊明
    • Journal Title

      奈良県総合医療センター医学雑誌

      Volume: 20 Pages: 4-9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Short-term influence of cataract surgery on circadian biological rhythm and related health outcomes (CLOCK-IOL trial): study protocol for a randomized controlled trial2014

    • Author(s)
      Saeki K, Obayashi K, Nishi T, Miyata K, Maruoka S, Ueda T, Okamoto M, Hasegawa T, Matsuura T, Tone N, Ogata N, Kurumatani N
    • Journal Title

      Trials

      Volume: 29 Issue: 1 Pages: 514-522

    • DOI

      10.1186/1745-6215-15-514

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 乱視矯正眼内レンズ使用時の乱視軸マーキング法の検討2014

    • Author(s)
      後岡克則、林良子、夏目恵冶、伊集院信夫、松浦豊明、緒方奈保子
    • Journal Title

      IOL&RS

      Volume: 28 Pages: 86-89

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 5 術中合併症  光学部と支持部の固着2014

    • Author(s)
      葛城 良昌、松浦 豊明
    • Journal Title

      眼内レンズの使いかた専門医のための眼科診療クオリファイ

      Volume: 20 Pages: 231-232

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ocular blood flow before, during, and after vitrectomy determined by laser speckle flowgraphy.2014

    • Author(s)
      Masahiro Okamoto, Toyoaki Matsuura, Nahoko Ogata.
    • Journal Title

      Ophthalmic Surg Lasers Imaging Retina

      Volume: 45 Issue: 2 Pages: 118-124

    • DOI

      10.3928/23258160-20140306-04

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Structure of vitreous body and its relationship with liquefaction2013

    • Author(s)
      Makoto Kodama, Toyoaki Matsuura, Yoshiaki Hara
    • Journal Title

      Biomedical Science and Engineering

      Volume: 6 Issue: 07 Pages: 739-745

    • DOI

      10.4236/jbise.2013.67091

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Injectable in Situ Gelation Biomaterials for Intraocular Applications2012

    • Author(s)
      Masahiko Annaka, K. Mortensen, T. Matsuura
    • Journal Title

      Kyushu University Global-COE program Science for Future Molecular Systems Journal 2009

      Volume: Vol. 5 Pages: 153-159

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Organic-inorganic nanocomposite gels as an in situ gelation biomaterial for injectable accommodative intraocular lens2012

    • Author(s)
      Masahiko Annaka, Kell Mortensen, Toyoaki Matsuura, Masaya Ito, Katsunori Nochioka, Nahoko Ogata
    • Journal Title

      Soft Matter

      Volume: 8 Issue: 27 Pages: 7185-96

    • DOI

      10.1039/c2sm25534k

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Evaluation of accommodation at hydrogel lens refilling2015

    • Author(s)
      Toyoaki Matsuura
    • Organizer
      International Conference on the Lens 2015
    • Place of Presentation
      Sheraton Kona Resort & Spa At Keauhou Bay
    • Year and Date
      2015-12-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Injectable Hydrogel Vitreous Body with Tamponade Effect2014

    • Author(s)
      Toyoaki Matsuura
    • Organizer
      WOC 2014
    • Place of Presentation
      Tokyo International Forum
    • Year and Date
      2014-04-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Evaluation of Refraction and Accommodation at Lens Refilling2014

    • Author(s)
      Toyoaki Matsuura
    • Organizer
      WOC 2014
    • Place of Presentation
      Tokyo International Forum
    • Year and Date
      2014-04-04
    • Related Report
      2014 Research-status Report 2013 Research-status Report
  • [Presentation] njectable Hydrogel Vitreous Body with Tamponade Effect2014

    • Author(s)
      Toyoaki Matsuura
    • Organizer
      WOC 2014
    • Place of Presentation
      Tokyo International Forum
    • Related Report
      2013 Research-status Report
  • [Presentation] Organic-Inorganic Nanocomposite Gel as In Situ Gelation Biomaterilal for Injectable Accommodative Intraocular Lens2012

    • Author(s)
      松浦豊明
    • Organizer
      .15th International Small Angle ScatteringConference2012
    • Place of Presentation
      Sydney Convention and Exhibition Centre
    • Related Report
      2012 Research-status Report
  • [Presentation] Organic-Inorganic Nanocomposite Gel as In Situ Gelation Biomaterilal for Injectable Accommodative Intraocular Lens2012

    • Author(s)
      松浦豊明
    • Organizer
      Polyelectrolyte 2012
    • Place of Presentation
      Lausanne, Switzerland
    • Related Report
      2012 Research-status Report
  • [Presentation] Lens refilling での屈折、調節

    • Author(s)
      松浦豊明
    • Organizer
      日本生体材料研究会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 新しい素材による水晶体再建

    • Author(s)
      松浦豊明
    • Organizer
      第117回日本眼科学会総会
    • Place of Presentation
      東京フォーラム
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] 眼科診療クオリファイ。眼内レンズの使いかた2014

    • Author(s)
      葛城良昌、松浦豊明
    • Total Pages
      380
    • Publisher
      中山書店
    • Related Report
      2014 Research-status Report
  • [Remarks] 調節能のある人工水晶体の開発

    • URL

      http://www.naramed-u.ac.jp/~oph/theme/pages/k5.html

    • Related Report
      2012 Research-status Report
  • [Remarks] 分散系物理化学研究室

    • URL

      http://www.scc.kyushu-u.ac.jp/aboratory/

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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