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How synaptic remodeling associated photoreceptor degeneration affects retinal function

Research Project

Project/Area Number 24592677
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionDokkyo Medical University (2014)
Iwate Medical University (2012-2013)

Principal Investigator

MACHIDA Shigeki  獨協医科大学, 医学部, 教授 (30285613)

Co-Investigator(Kenkyū-buntansha) FUJIWARA Takamitsu  岩手医科大学, 医学部, 講師 (30405766)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Keywords網膜電図 / 網膜 / 視細胞変性 / 網膜変性 / 緑内障 / 黄斑円孔 / 網膜内層 / ERG / 網膜神経節細胞 / 網膜疾患 / 黄斑疾患
Outline of Final Research Achievements

We investigated functional changes of the inner retina in animal models and clinical cases. In the animal research, we isolated electrical responses from each retinal layer by intravitreally injecting drugs that blocks synaptic transmission. In early stage of photoreceptor degeneration, responses of the ON-bipolar cells were enhanced. In addition, sensitivity of amacrine cells to NMDA increased. In clinical research, we found that the photopic negative response (PhNR) driven by the inner retina were irreversibly deteriorated in macular hole patients treated by vitrectomy using indocyanine green. In glaucoma patients, in the macular region the PhNR amplitude severely declined with loss of the inner retinal thickness while in the extra-macular region it deteriorated gradually. This suggested that glaucoma should be categorized into macular disease.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (24 results)

All 2015 2014 2013 2012

All Journal Article (12 results) (of which Peer Reviewed: 12 results,  Open Access: 6 results,  Acknowledgement Compliant: 5 results) Presentation (11 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Differences in functional loss associated with ganglion cell complex thinning between patients with glaucoma and postoperative macular hole.2015

    • Author(s)
      Machida S, Tamada K, Ohzeki T, Gotoh Y, Kurosaka D.
    • Journal Title

      Curr Eye Res.

      Volume: 40 Issue: 4 Pages: 439-449

    • DOI

      10.3109/02713683.2014.922196

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Structures affecting recovery of macular function in patients with age-related macular degeneration after intravitreal ranibizumab.2015

    • Author(s)
      Nishimura T, Machida S, Hashizume K, Kurosaka D.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol.

      Volume: 253

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Differences in functional loss associated with ganglion cell complex thinning between patients with glaucoma and postoperative macular hole.2014

    • Author(s)
      Machida S, Tamada K, Ohzeki T, Gotoh Y, Kurosaka D.
    • Journal Title

      Curr Eye Res.

      Volume: 39 Issue: 8 Pages: 845-852

    • DOI

      10.3109/02713683.2013.879596

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Comparisons of cone electroretinograms after indocyanine green-, brilliant blue G-, or triamcinolone acetonide-assisted macular hole surgery.2014

    • Author(s)
      Machida S, Toba Y, Nishimura T, Ohzeki T, Murai K, Kurosaka D.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol.

      Volume: 252 Issue: 9 Pages: 1423-1433

    • DOI

      10.1007/s00417-014-2594-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Comparison of retinal nerve fiber layer thickness after indocyanine green, brilliant blue G, or triamcinolone acetonide-assisted macular hole surgery.2014

    • Author(s)
      Toba Y, Machida S, Kurosaka D.
    • Journal Title

      J Ophthalmology

      Volume: 2014 Pages: 187308-187308

    • DOI

      10.1155/2014/187308

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Alterations of Photopic Negative Response of Multifocal Electroretinogram in Patients with Glaucoma2014

    • Author(s)
      Muneyoshi Kaneko, Shigeki Machida, Yuya Hoshi, Daijiro Kurosaka
    • Journal Title

      Current Eye Research

      Volume: in press Issue: 1 Pages: 77-86

    • DOI

      10.3109/02713683.2014.915575

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of cone electoretinograms after indocyanine green-, brilliant blue G-, or triamcinolone acetonide-assisted macukar hole surgery2014

    • Author(s)
      Machida S, Toba Y, Nishimura T, Ohzeki T, Murai K, Kurosaka D
    • Journal Title

      Graefes Arch Ophthalmol Clin Exp

      Volume: 未定

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differences in functional loss associated with ganglion cell complex thinning between patients with glaucoma and postoperative macular hole2014

    • Author(s)
      Machida S, Tamada K, Ohzeki T, Gotoh Y, Kurosaka D
    • Journal Title

      Curr Eye Res

      Volume: 未定

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Contribution of N-Methyl-DL-Aspartic Acid (NMDA)-sensitive neurons to generating oscillatory potentials in Royal College of Surgeons rats2013

    • Author(s)
      Harada T, Machida S, NIshimura T, Kurosaka D
    • Journal Title

      Doc Ophthalmologica

      Volume: 127 Pages: 131-140

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical application of photopic negative response to optic nerve and retinal diseases.2012

    • Author(s)
      Machida S.
    • Journal Title

      J Ophthalmol.

      Volume: 397178 Pages: 397178-397178

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Retinal ganglion cell function after repeated intravitreal injections of ranibizumab in patients with age-related macular degeneration.2012

    • Author(s)
      Nishimura T, Machida S, Harada T, Kurosaka D.
    • Journal Title

      Clin Ophthalmol.

      Volume: 6 Pages: 1073-1082

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Macular function evaluated by focal macular electroretinogram after reduced fluence photodynamic therapy in eyes with polypoidal choroidal vasculopathy.2012

    • Author(s)
      Machida S, Tamada K, Nishimura T, Harada T, Kurosaka D.
    • Journal Title

      Doc Opthalmol.

      Volume: 124 Pages: 91-98

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 網膜内層厚が網膜神経節細胞機能に与える影響 緑内障眼と黄斑円孔術後眼の比較2014

    • Author(s)
      町田 繁樹、玉田 邦房、大関 尚行、後藤 恭孝、黒坂大次郎
    • Organizer
      第68回 日本臨床眼科学会
    • Place of Presentation
      神戸
    • Year and Date
      2014-11-13 – 2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Comparisons of cone electroretinograms after indocyanine green-, brilliant blue G-, or triamcinolone acetonide-assisted macular hole surgery.2014

    • Author(s)
      Machida S, Toba Y, Nishimura T, Ohzeki T, Murai K, Kurosaka D
    • Organizer
      13th Congress of the International Society of Ocular Toxicology.
    • Place of Presentation
      金沢
    • Year and Date
      2014-10-09 – 2014-10-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 滲出型加齢黄斑変性の治療後の黄斑機能改善に影響を与える光干渉断層計所見2014

    • Author(s)
      西村 智治、町田 繁樹、橋爪 公平、黒坂大次郎
    • Organizer
      第62回 日本臨床視覚電気生理学会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-03 – 2014-10-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Differences in functional loss associated with ganglion cell complex thinning between patients with glaucoma and postoperative macular hole.2014

    • Author(s)
      Machida S, Tamada K, Ohzeki T, Gotoh Y, Kurosaka D.
    • Organizer
      The 52nd International Society for Clinical Electrophysiology of Vision
    • Place of Presentation
      ボストン
    • Year and Date
      2014-07-20 – 2014-07-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Contribution of N-Methyl-DL-Aspartic Acid (NMDA)-sensitive neurons to generating oscillatory potentials in Royal College of Surgeons rats2014

    • Author(s)
      Harada T, Machida S, NIshimura T, Kurosaka D
    • Organizer
      World Ophthalmology Congress 2014
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Comparison of cone electoretinograms after indocyanine green-, brilliant blue G-, or triamcinolone acetonide-assisted macukar hole surgery2013

    • Author(s)
      Machida S, Toba Y, Nishimura T, Ohzeki T, Murai K, Kurosaka D
    • Organizer
      51th International Society of Clinical Electrophysiology and Vision
    • Place of Presentation
      重慶
    • Related Report
      2013 Research-status Report
  • [Presentation] 黄斑円孔手術後の錐体網膜電図の変化2013

    • Author(s)
      町田繁樹、鳥羽陽春、西村智治、大関尚行、村井憲一、黒坂大次郎
    • Organizer
      第67回 日本臨床眼科学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] Pharmacological dissection of cone ERGs of Pro347Leu rhodopsin transgenic rabbits.2012

    • Author(s)
      Machida S, Nishimura T, Kondo M, Terasaki H, Yokoyama D, Kurosaka D
    • Organizer
      50th International Society of Clinical Electrophysiology symposium
    • Place of Presentation
      Valencia
    • Related Report
      2012 Research-status Report
  • [Presentation] Retinal ganglion cell function after repeated intravitreal injections of ranibizumab in patients with age-related macular degeneration.2012

    • Author(s)
      Nishimura T, Machida S, Harada T, Kurosaka D.
    • Organizer
      50th International Society of Clinical Electrophysiology symposium
    • Place of Presentation
      Valencia
    • Related Report
      2012 Research-status Report
  • [Presentation] Enhancement of ON-bipolar cell response of cone ERGs in rabbits with Pro347Leu rhodopsin mutation2012

    • Author(s)
      Nishimura T, Machida S, Kondo M, Terasaki H, Yokoyama D, Kurosaka D
    • Organizer
      ISCEV@ARVO
    • Place of Presentation
      Fort Lauderdale
    • Related Report
      2012 Research-status Report
  • [Presentation] 視細胞変性動物モデルの機能解析2012

    • Author(s)
      町田 繁樹
    • Organizer
      第116回日本眼科学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] どうとる?どう読む?ERG2015

    • Author(s)
      山本 修一、新井 三樹、近藤 峰生、町田 繁樹、篠田 啓
    • Total Pages
      159
    • Publisher
      MEDICal VIEW
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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