Analysis of miRNA signatures in Behcets disease patients treated with infliximab
Project/Area Number |
24592678
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Ophthalmology
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Research Institution | Kyorin University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
KEINO Hiroshi 杏林大学, 眼科学教室, 准教授 (90328211)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 免疫 / 免疫学 / ぶどう膜炎 |
Outline of Final Research Achievements |
To determine the effect of infliximab on microRNA (miRNA) expression in peripheral blood mononuclear cells of Behcet's disease patients before and after initiation of infliximab treatment, we analyzed miRNA expression profiles in 4 patients at baseline and at 22 weeks after initiation of infliximab. Anti-TNF-α antibody therapy reduced the frequency of ocular attacks in 3 of 4 patients during 2 years of follow-up, while one patient continued to have inflammatory relapses during that time. Several miRNAs were increased or decreased in each patient. Although the expression of miRNA-144 was decreased in all 3 patients with no relapses, its expression was increased in the one patient who continued to have relapses. MiRNA-144 may represent a new biomarker for monitorings response to infliximab in the treatment of Behcet’s disease with refractory uveoretinitis.
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Report
(4 results)
Research Products
(56 results)
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[Journal Article] Development and validation of new diagnostic criteria for acute retinal necrosis.2015
Author(s)
Takase H, Okada AA, Goto H, Mizuki N, Namba K, Ohguro N, Sonoda KH, Tomita M, Keino H, Kezuka T, Kubono R, Mizuuchi K, Shibuya E, Takahashi H, Yanai R, Mochizuki M
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Journal Title
Jpn J Ophthalmol
Volume: 59(1)
Issue: 1
Pages: 14-20
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Evaluation of the long-term efficacy and safety of infliximab treatment for uveitis in Behçet's disease: a multicenter study.2014
Author(s)
Takeuchi M, Kezuka T, Sugita S, Keino H, Namba K, Kaburaki T, Maruyama K, Nakai K, Hijioka K, Shibuya E, Komae K, Hori J, Ohguro N, Sonoda KH, Mizuki N, Okada AA, Ishibashi T, Goto H, Mochizuki M.
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Journal Title
Ophthalmology.
Volume: 121
Pages: 1877-1884
Related Report
Peer Reviewed
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[Journal Article] Multicenter study of infliximab for refractory uveoretinitis in Behcet disease.2012
Author(s)
Okada AA, Goto H, Ohno S, Mochizuki M, Kitaichi N, Namba K, Keino H, Watanabe T, Ishibashi T, Ito T, Sonoda K, Nakai K, Ohguro N, Sugita S, Kezuka T, Kaburaki T, Takamoto M, Mizuki N.
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Journal Title
Arch Ophthalmol.
Volume: 130
Issue: 5
Pages: 592-598
DOI
Related Report
Peer Reviewed
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[Journal Article] Clinical spectrum of tuberculous optic neuropathy2012
Author(s)
Davis EJ, Rathinam SR, Okada AA, Tow SL, Petrushkin H, Graham EM, Chee SP, Guex-Crosier Y, Jakob E, Tugal-Tutkun I, Cunningham ET Jr, Leavitt JA, Mansour AM, Winthrop KL, Hills WL, Smith JR
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Journal Title
J Ophthalmic Inflamm Infect
Volume: 2
Issue: 4
Pages: 183-189
DOI
Related Report
Peer Reviewed
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[Book] 眼科2014
Author(s)
慶野博、岡田アナベルあやめ
Total Pages
4
Publisher
金原出版
Related Report
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