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Three dimensional vascular images of choroidal disease

Research Project

Project/Area Number 24592682
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionTokyo Medical University

Principal Investigator

MIURA Masahiro  東京医科大学, 医学部, 准教授 (60199958)

Co-Investigator(Renkei-kenkyūsha) YASUNO Yoshiaki  筑波大学, 数理物質科学研究科, 講師 (10344871)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords網脈絡膜疾患 / ドップラー計測 / 光干渉断層計 / 血管 / 3次元画像 / ドップラー信号計測 / 血管3次元画像 / 脈絡膜血管 / 加齢黄斑変性
Outline of Final Research Achievements

Using Doppler optical coherence tomography(OCT), we can quantitatively evaluate the human blood flow volume in choroid and retina, and human three-dimensional (3-D) chorioretinal vascular architecture, in vivo. 1) Doppler OCT with plethysmography provided an accurate quantitative assessment of the absolute blood flow volume in choroidal vessels. 2) We preliminary evaluated 3-D vascular structure of various exudative macular disease using Doppler OCT. 3) We evaluated the 3-D architectureof neovascularization in proliferative diabetic retinopathy using Doppler OCT. 4) The therapeutic effect after three consecutive intravitreal aflibercept injections for polypoidal choroidal neovascularization was evaluated using Doppler OCT. Doppler OCT imaging is noninvasive, has a short measurement time, and may potentially function as a noninvasive alternative to FA and ICGA for the assessment of various chorioretinal vascular diseases.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (37 results)

All 2015 2014 2013 2012 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Acknowledgement Compliant: 3 results,  Open Access: 2 results) Presentation (25 results) (of which Invited: 2 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Three-Dimensional Vascular Imaging of Proliferative Diabetic Retinopathy by Doppler Optical Coherence Tomography2015

    • Author(s)
      Miura M, Hong YJ, Yasuno Y, Muramatsu D, Iwasaki T, Goto H.
    • Journal Title

      Am J Ophthalmol

      Volume: 159 Issue: 3 Pages: 528-538

    • DOI

      10.1016/j.ajo.2014.12.002

    • NAID

      120007130327

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Noninvasive Vascular Imaging of Polypoidal Choroidal Vasculopathy by Doppler Optical Coherence Tomography.2015

    • Author(s)
      Miura M, Muramatsu D, Hong YJ, Yasuno Y, ,Iwasaki T, Goto H.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 印刷中 Issue: 5 Pages: 3179-3179

    • DOI

      10.1167/iovs.14-16252

    • NAID

      120007136326

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Simultaneous investigation of vascular and retinal pigment epithelial pathologies of exudative macular diseases by multifunctional optical coherence tomography2014

    • Author(s)
      Hong YJ, Miura M, Ju MJ, Makita S, Iwasaki T, Yasuno Y.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 55 Issue: 8 Pages: 5016-5031

    • DOI

      10.1167/iovs.14-14005

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Degree of polarization uniformity with high noise immunity using polarization-sensitive optical coherence tomography2014

    • Author(s)
      Makita S, Hong YJ, Miura M, Yasuno Y.
    • Journal Title

      Opt Lett.

      Volume: 39 Issue: 24 Pages: 6783-6786

    • DOI

      10.1364/ol.39.006783

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Advanced multi-contrast Jones matrix optical coherence tomography for Doppler and polarization sensitive imaging2013

    • Author(s)
      Ju MJ, Hong YJ, Makita S; Lim Y, Kurokawa K, Duan L, Miura M, Tang S, Yasuno Y
    • Journal Title

      Optics Express

      Volume: 21 Issue: 16 Pages: 19412-19436

    • DOI

      10.1364/oe.21.019412

    • NAID

      120007136831

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Noninvasive Investigation of Deep Vascular Pathologies of Exudative Macular Diseases by High Penetration Optical Coherence Angiography2013

    • Author(s)
      Young-Joo Hong, Masahiro Miura, Shuichi Makita, Myeong-Jin Ju, Byeong Ha Lee, Takuya Iwasaki, Yoshiaki Yasuno
    • Journal Title

      Investigative Ophthalmology & Vision Science

      Volume: 54 Issue: 5 Pages: 3621-31

    • DOI

      10.1167/iovs.12-11184

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Noninvasive Investigation of Deep Vascular Pathologies of Exudative Macular Diseases by High Penetration Optical Coherence Angiography2013

    • Author(s)
      Hong YJ, Miura M, Makita S, Ju MJ, Lee BH, Iwasaki T, Yasuno Y
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 44

    • NAID

      120007130520

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] An approach to measure blood flow in single choroidal vessel using Doppler optical coherence tomography.2012

    • Author(s)
      Miura M, Makita S, Iwasaki T, Yasuno Y.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 53 Issue: 11 Pages: 731-747

    • DOI

      10.1167/iovs.12-10666

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] High-penetration swept source Doppler optical coherence angiography by fully numerical phase stabilization2012

    • Author(s)
      Young-Joo Hong, Shuichi Makita, Franck Jaillon, Myeong Jin Ju, Eun Jung Min, Byoeng Ha Lee, Masahide Itoh, Masahiro Miura, Yoshiaki Yasuno
    • Journal Title

      Optics Express

      Volume: 20 Issue: 3 Pages: 2740-2760

    • DOI

      10.1364/oe.20.002740

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] High-penetration optical coherence tomography with enhanced depth imaging of polypoidal choroidal vasculopathy.2012

    • Author(s)
      Nagase S, Miura M, Makita S, Iwasaki T, Goto H, Yasuno Y.
    • Journal Title

      Ophthalmic Surg Lasers Imaging

      Volume: 43 Issue: 6

    • DOI

      10.3928/15428877-20120130-02

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Doppler optical coherence tomographyによって観察した網膜細動脈瘤破裂の1例2014

    • Author(s)
      伊丹彩子、三浦雅博、村松大弐、Young-Joo Hong, 安野嘉晃、岸田英之、岩﨑琢也、後藤浩
    • Organizer
      第53回日本網膜硝子体学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2014-11-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Doppler optical coherence tomographyによる糖尿病網膜症の観察2014

    • Author(s)
      三浦雅博、村松大弐、Young-Joo Hong, 安野嘉晃、岸田英之、岩﨑琢也、後藤浩
    • Organizer
      第53回日本網膜硝子体学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2014-11-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 最新のOCTの臨床応用の可能性2014

    • Author(s)
      三浦雅博
    • Organizer
      第50回日本眼光学学会
    • Place of Presentation
      金沢
    • Year and Date
      2014-09-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Detection of polypoidal lesions in polypidal choroidal vasculopathy with high-penetration high-sensitive optical coherence angiography.2014

    • Author(s)
      Hideyuki Kishida, Daisuke Muramatsu, Hong Young-Joo, Yoshiaki Yasuno, Takuya Iwasaki, Hiroshi Goto, Masahiro Miura,
    • Organizer
      Annual meeting of the association for research in vision and ophthalmology
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2014-05-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Three dimensional non-invasive vascular imaging of proliferative diabetic retinopathy by optical coherence angiography2014

    • Author(s)
      Masahiro Miura, Daisuke Muramatsu, Hideyuki Kishida, Hong Young-Joo, Yoshiaki Yasuno, Takuya Iwasaki, Hiroshi Goto
    • Organizer
      Annual meeting of the association for research in vision and ophthalmology
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2014-05-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] High-speed 1-μm Jones-matrix Multi-contrast Optical Coherence Tomography for Simultaneous 3D Doppler and Polarization Imaging2014

    • Author(s)
      Hong Young-Joo1,Miura Masahiro,Makit Shuichi, Yasuno, Yoshiaki,
    • Organizer
      Annual meeting of the association for research in vision and ophthalmology
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2014-05-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Three dimensional non-invasive vascular imaging of retinal vascular occlusion by optical coherence angiography2014

    • Author(s)
      Daisuke Muramatsu, Hideyuki Kishida, Hong Young-Joo, Yoshiaki Yasuno, Takuya Iwasaki, Hiroshi Goto, Masahiro Miura
    • Organizer
      Annual meeting of the association for research in vision and ophthalmology
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2014-05-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Simultaneous 3-D Doppler and Polarization OCT of Exudative Macular Diseases Before and After Intravitreal Ranibizumab Injection2014

    • Author(s)
      Yoshiaki Yasuno, Young-Joo Hong, Masahiro Miura
    • Organizer
      Annual meeting of the association for research in vision and ophthalmology
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2014-05-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Optical coherence angiographyによるポリープ状脈絡膜血管症のポリープ状病巣の検出2014

    • Author(s)
      阿川哲也、三浦雅博、村松大弐、Young-Joo Hong,岩﨑琢也、後藤浩、安野嘉晃
    • Organizer
      日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Optical coherence angiographyによる増殖性糖尿病網膜症の観察2014

    • Author(s)
      三浦雅博、村松大弐、Young-Joo Hong,岩﨑琢也、後藤浩、安野嘉晃
    • Organizer
      日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Optical coherence angiographyによる網膜血管閉塞の観察2014

    • Author(s)
      村松大弐、三浦雅博、Young-Joo Hong、岩﨑琢也、後藤浩、安野嘉晃
    • Organizer
      日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Microvasculature Imaging by Wide Field Dual-Beam Optical Coherence Angiography2013

    • Author(s)
      Makita S, Kurokawa K, Miura M, Yasuno Y
    • Organizer
      Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Seattle, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Simultaneous 3D Doppler and Polarization Imaging of Macular Pathologies by Polarization-Sensitive Optical Coherence Angiography2013

    • Author(s)
      Hong YJ, Miura M, Ju MJ, Makita S, Yasuno Y
    • Organizer
      Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Seattle, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Visualization and Automatic Diameter Evaluation of In Vivo Choroidal Vessels by High-Penetration Optical Coherence Tomography2013

    • Author(s)
      Yasuno Y, Hong YJ, Ju MJ, Miura M, Duan L
    • Organizer
      Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Seattle, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Simultaneous birefringence and flow imaging with Multifunctional Jones matrix optical coherence tomography2013

    • Author(s)
      Ju MJ, Hong YJ, Makita S, Miura, Tang S, Yasuno Y
    • Organizer
      Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Seattle, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] In Vivo Non-invasive Abnormal Vasculature Imaging by High-Sensitivity Optical Coherence Angiography2012

    • Author(s)
      Makita S, Jallion F, Miura M, Yasuno Y
    • Organizer
      Annual meeting of the association for research in vision and ophthalmology
    • Place of Presentation
      Fort Lauderdale
    • Related Report
      2012 Research-status Report
  • [Presentation] Choroidal circulation imaging with variable velocity range dual beam optical coherence angiography2012

    • Author(s)
      Jallion F, Makita S, Miura M, Yasuno Y
    • Organizer
      Annual meeting of the association for research in vision and ophthalmology
    • Place of Presentation
      Fort Lauderdale
    • Related Report
      2012 Research-status Report
  • [Presentation] Non-invasive Vascular Imaging of Exudative Macular Disease by High Penetration Doppler Optical Coherence Angiography2012

    • Author(s)
      Hong YJ, Miura M, Makita S, Ju MJ, Lee BH, Iwasaki T, Yasuno Y
    • Organizer
      Annual meeting of the association for research in vision and ophthalmology
    • Place of Presentation
      Fort Lauderdale
    • Related Report
      2012 Research-status Report
  • [Presentation] Quantitative choroidal blood flow measurement using Doppler optical coherence tomography with pulse synchronization.2012

    • Author(s)
      Miura M, Makita S, Iwasaki T, Yasuno Y.
    • Organizer
      Annual meeting of the association for research in vision and ophthalmology
    • Place of Presentation
      Fort Lauderdale
    • Related Report
      2012 Research-status Report
  • [Presentation] 超高感度ドップラー光干渉断層計による網脈絡膜血管3次元構造観察2012

    • Author(s)
      三浦雅博、巻田修一、岩崎琢也、後藤浩、安野嘉晃
    • Organizer
      日本眼科学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] ポリープ状脈絡膜血管症の3次元構造2012

    • Author(s)
      三浦雅博、巻田修一、岩崎琢也、安野嘉晃
    • Organizer
      第24回茨城県眼医会集談会
    • Place of Presentation
      水戸
    • Related Report
      2012 Research-status Report
  • [Presentation] ドップラー光干渉断層計による脈絡膜血流量の計測2012

    • Author(s)
      三浦雅博、巻田修一、岩崎琢也、後藤浩、安野嘉晃
    • Organizer
      第51回日本網膜硝子体学会
    • Place of Presentation
      甲府
    • Related Report
      2012 Research-status Report
  • [Presentation] Doppler OCT

    • Author(s)
      三浦雅博
    • Organizer
      第117回日本眼科学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Dual-beam optical coherence angiographyによるポリープ状脈絡膜血管症の観察

    • Author(s)
      三浦雅博、巻田修一、岩﨑琢也、安野嘉晃
    • Organizer
      第30回日本眼循環学会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Novel analysis for macular disease with High-penetration Doppler optical coherence angiography

    • Author(s)
      Mutramatsu D, Hong YJ, Miura M, Iwasaki T, Goto H, Yasuno Y
    • Organizer
      Asia Pacific Vitreo-retinal Soceity
    • Place of Presentation
      Nagoya
    • Related Report
      2013 Research-status Report
  • [Book] ドップラOCTと偏光OCT、専門医のための眼科診療クオリファイ18、眼科OCTのすべて2013

    • Author(s)
      三浦雅博
    • Publisher
      中山書店
    • Related Report
      2013 Research-status Report
  • [Remarks] About Masahiro Miura, MD, PhD

    • URL

      http://www.tokyo-med.ac.jp/iba-eye/miura_title.html

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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