| Project/Area Number |
24592682
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YASUNO Yoshiaki 筑波大学, 数理物質科学研究科, 講師 (10344871)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 網脈絡膜疾患 / ドップラー計測 / 光干渉断層計 / 血管 / 3次元画像 / ドップラー信号計測 / 血管3次元画像 / 脈絡膜血管 / 加齢黄斑変性 |
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| Outline of Final Research Achievements |
Using Doppler optical coherence tomography(OCT), we can quantitatively evaluate the human blood flow volume in choroid and retina, and human three-dimensional (3-D) chorioretinal vascular architecture, in vivo. 1) Doppler OCT with plethysmography provided an accurate quantitative assessment of the absolute blood flow volume in choroidal vessels. 2) We preliminary evaluated 3-D vascular structure of various exudative macular disease using Doppler OCT. 3) We evaluated the 3-D architectureof neovascularization in proliferative diabetic retinopathy using Doppler OCT. 4) The therapeutic effect after three consecutive intravitreal aflibercept injections for polypoidal choroidal neovascularization was evaluated using Doppler OCT. Doppler OCT imaging is noninvasive, has a short measurement time, and may potentially function as a noninvasive alternative to FA and ICGA for the assessment of various chorioretinal vascular diseases.
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