Evaluation of new medical treatment and its clinical development for adenoviral ocular infectious diseases
| Project/Area Number |
24592686
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Fukuoka University |
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Principal Investigator |
UCHIO Eiichi 福岡大学, 医学部, 教授 (70232840)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | アデノウイルス / 抗ウイルス薬 / 結膜炎 / 感染症 / 薬物治療 / 治療薬 / ガンシクロビル / ウイルス |
|---|
| Outline of Final Research Achievements |
Effectiveness of ganciclovir against adenovirus types inducing conjunctivitis in humans were evaluated. Incubation system with A549 cells and adenovirus types 3, 4, 8, 19a and 37 were used. Adenovirus was treated with various concentrations of ganciclovir for 24 hours. After seven days' incubation, adenovirus DNA was measured by real time PCR method. CC50 (50% cytotoxity concentration) and EC50 (50% effective concentration) was used for evaluation. Average CC50 of ganciclovir was 212 microg/ml and EC50 ranged between 2.64 and 5.10 microg/ml. Significant inhibitory effect was observed in all types studied. These results indicate that ganciclovir may be a candidate of treatment measure for adenoviral ocular diseases.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Therapeutic effects of 0.1% tacrolimus eye drops for refractory allergic ocular diseases with proliferative lesion or corneal involvement.2014
Author(s)
Fukushima A, Ohashi Y, Ebihara N, Uchio E, Okamoto S, Kumagai N, Shoji J, Takamura E, Nakagawa Y, Namba K, Fujishima H, Miyazaki D
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Journal Title
Br J Ophthalmol.
Volume: 98
Issue: 8
Pages: 1023-1027
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] ウイルス性結膜炎2014
Author(s)
内尾英一
Organizer
第118回日本眼科学会総会
Place of Presentation
東京都
Year and Date
2014-04-05
Related Report
Invited
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