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Development of new procedure of diaphragmatic repair using tissue engineering approach

Research Project

Project/Area Number 24592691
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatric surgery
Research InstitutionUniversity of Tsukuba

Principal Investigator

URITA Yasuhisa  筑波大学, 医学医療系, 講師 (90361352)

Co-Investigator(Kenkyū-buntansha) 増本 幸二  筑波大学, 医学医療系, 教授 (20343329)
Co-Investigator(Renkei-kenkyūsha) MASUMOTO Kouji  筑波大学, 医学医療系, 教授 (20343329)
CHEN Guoping  独立行政法人物質, 材料機構・生体材料工学研究所, 主幹研究員 (50357505)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords先天性横隔膜ヘルニア / PLGA / Hybrid Scaffold / 骨格筋 / 骨格筋再生 / 横隔膜ヘルニア / 再生医療
Outline of Final Research Achievements

In order to improve the Quality of life and prevention of the thorax deformation after the introduction of the artificial membrane in congenital diaphragmatic hernia(CDH) treatment, CDH rat model had been development.
When the folding sheet was sewing, an omentum leaving a vascular system with its pedicle was interposed between the sheets. We have developed a new CDH repair procedure in order to examine whether it is possible to muscle regeneration by the omentum that is fed by the blood vessels into "new diaphragm".

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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