Molecular Analysis of CEACAM Family in Hepatoblastoma

• Project/Area Number: 24592693
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatric surgery
• Research Institution: Niigata University
• Principal Investigator: NAKAYA KENGO 新潟大学, 医歯学系, 助教 (20625173)
• Co-Investigator(Kenkyū-buntansha): WAKAI Toshifumi 新潟大学, 医歯学系, 教授 (50372470) ; KUBOTA Masayuki 新潟大学, 医歯学系, 教授 (50205150)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 肝芽腫 / CEACAM / 接着因子 / CEACAM6 / CEACAM1 / 病期 / 遠隔転移

Outline of Final Research Achievements

Hepatoblastoma is an uncommon malignant liver cancer occurring in infants and children. Currently the survival rate of hepatoblastoma has been better improved, but the prognosis is still poor when the disease is unresectable. In this study, we addressed whether carcinoembryonic antigen-related cell adhesion molecule (CEACAM), a type of adhesion molecule involved in cancer progression, has any impact on the prognosis of hepatoblastoma. The results of our immunohistochemical analysis showed that the cases with increased levels of CEACAM6 expression relatively exhibited advanced tumor stage with lung metastasis. Based on these obtained results, CEACAM6 might play a role on cancer metastasis in hepatoblastoma.

Research Products

• [Journal Article] The area and attachment abnormalities of the gubernaculum in patients with undescended testes in comparison with those with retractile testes. (2014)
  • Author(s): Kubota M, Nakaya K, Arai Y, Ohyama T, Yokota N, Nagai Y.
  • Journal Title: Pediatr Surg Int Volume: 30 (11) Issue: 11 Pages: 1149-1154
  • DOI: 10.1007/s00383-014-3597-4
  • Peer Reviewed
• [Journal Article] 本県における神経芽腫マス・スクリーニング休止後の神経芽腫臨床像の変化 (2014)
  • Author(s): 荒井 勇樹, 窪田 正幸, 仲谷 健吾, 大山 俊之, 横田 直樹
  • Journal Title: 日本小児血液・がん学会雑誌 Volume: 51 (4) Pages: 245-245
  • Peer Reviewed
• [Journal Article] 小児の外科的悪性腫瘍、2012年登録症例の全国集計結果の報告 (2014)
  • Author(s): 米倉 竹夫, 田尻 達郎, 伊勢 一哉, 小野 滋, 大植 孝治, 佐藤 智行, 杉藤 公信, 菱木 知郎, 平井 みさ子, 文野 誠久, 本多 昌平, 風間 理郎, 杉山 正彦, 中田 光政, 仲谷 健吾, 脇坂 宗親, 近藤 知史, 上原 秀一郎, 鬼武 美幸, 木下 義晶,
  • Journal Title: 日本小児外科学会雑誌 Volume: 50 (1) Pages: 114-150
  • Peer Reviewed
• [Journal Article] Effects of rapamycin on granulation formation in response to centrally-doubled coiled stents as a tracheal substitute. (2013)
  • Author(s): Kubota M, Matsuda Y, Fujimaki S, Osawa M, Wakai T, Nakaya K
  • Journal Title: J Pediatr Surg Volume: 48 Issue: 12 Pages: 2416-2424
  • DOI: 10.1016/j.jpedsurg.2013.08.013
  • Peer Reviewed
• [Journal Article] Risk of subsequent biliary malignancy in patients undergoing cyst excision for congenital choledochal cysts. (2013)
  • Author(s): Ohashi T, Wakai T, Kubota M, Matsuda Y, Arai Y, Ohyama T, Nakaya K, Okuyama N, Sakata J, Shirai Y, Ajioka Y
  • Journal Title: J Gastroenterol Hepatol Volume: 28 Issue: 2 Pages: 243-247
  • DOI: 10.1111/j.1440-1746.2012.07260.x
  • Peer Reviewed