New transplantation strategy of gut like organ differentiation from pluripotent stem cells by tissue engineering
| Project/Area Number |
24592699
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKESHI Ueda 奈良県立医科大学, 附属病院, 研究員 (40526810)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 多能性幹細胞 / 腸管分化誘導 / 組織工学 / iPS細胞 / 脂肪由来幹細胞 / 短腸症候群 / 細胞シート |
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| Outline of Final Research Achievements |
We tried to perform the long-term culture in vitro with our gut-like organ differentiation from induced pluripotent stem (iPS) cells. We paid attention to adipose tissue-derived stem cells (ADSC) with ability for angiogenesis, we cultured iPS cells and ADSCs together. We tried to differentiation of intestinal mesentery, we demonstrated that ADSCs expressed the vascular endothelial marker genes such as CD31. However we could not develop fatty tissue with vascular formation by tissue-engineering technique. We tried to angiogenesis for gut-like organ using the embryoid body from iPS cells and ADSCs by three-demensional culture. We could not confirm the vascular formation. We could not demonstrate the angiogenesis with vascular formation for gut-like organ in vitro.
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Report
(4 results)
Research Products
(5 results)
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[Presentation] IBD合併癌(Colitic Cancer)のサーベイランスと治療 本邦報告例集積からみたクローン病合併直腸肛門部癌の特徴 cancer surveillanceに向けた検討2014
Author(s)
植田 剛, 小山 文一, 中川 正, 中村 信治, 錦織 直人, 井上 隆, 川崎 敬次郎, 尾原 伸作, 中本 貴透, 藤井 久男, 中島 祥介
Organizer
第69回日本大腸肛門病学会学術集会
Place of Presentation
横浜
Year and Date
2014-11-07 – 2014-11-08
Related Report
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