Eosinophilic inflammation associated with congenital gastrointestinal obstructive anomalies
| Project/Area Number |
24592702
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Gunma Institute of Public Health and Environmental Sciences |
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Principal Investigator |
YAMADA Yoshiyuki 群馬県衛生環境研究所, 研究企画係, 研究員 (80309252)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Hitoshi 獨協医科大学, 医学部, 教授 (10326928)
TAGUCHI Tomoaki 九州大学, 医学(系)研究科(研究院), 教授 (20197247)
HAYASHI Yasuhide 群馬県環境衛生研究所, 研究企画係, 研究員 (30238133)
KATO Masahiko 東海大学, 医学部, 准教授 (30292593)
HIRATO Junko 群馬大学, 医学部附属病院, 准教授 (60208832)
KUROIWA Minoru 東邦大学, 医学部, 教授 (90234583)
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| Research Collaborator |
MATSUMOTO Kenji
NISHI Akira
SUZUKI Norio
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 先天性消化器疾病学 / 好酸球 / 先天性消化器疾患学 |
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| Outline of Final Research Achievements |
This study aimed to determine the relationship between eosinophilic gastrointestinal disorders (EGID) and congenital gastrointestinal (GI) obstructive anomalies such as Hirschsprung disease and congenital esophageal atresia and stenosis. Some patients with congenital GI obstructive anomalies had eosinophil-dominant infiltration in the GI tract. We analyzed these patients’ clinical findings and laboratory data and reported their characteristics. In addition, this study contributed to the development of methods to evaluate the inflammation and pathogenesis of EGID. In addition, a novel dietary treatment of eosinophilic gastroenteritis, the multiple-food elimination diet, was shown to be effective in these patients.
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Report
(4 results)
Research Products
(56 results)
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[Presentation] Interleukin-33 and thymic stromal lymphopoietin are preferentially elevated in the sera of infants with eosinophilic gastroenteritis
Author(s)
Nomura I, Matsuda A, Shoda T, Morita H, Arai K, Shimizu T, Yamada Y, Ohya Y, Saito H, Matsumoto K
Organizer
2014 AAAAI Annual Meeting
Place of Presentation
San Diego Convention Center(San Diego, USA)
Related Report
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