| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
We established technologies for collection of adipose tissue-derived multipotent progenitor, ADMP cells from subcutaneous adipose tissues, culture of the cells and differentiation to smooth muscle cells from the cells. Moreover we transplanted the cells into animals and analyzed engraftment and differentiation of them, thereby optimizing the processes.
The achievement could be expected to provide development of safe and minimally invasive treatment for diseases caused by smooth muscle dysfunction. With our current technologies, we can obtain ADMP cells by harvesting only small amount of subcutaneous adipose tissues and culture without gene transfer. The transfusion of the ADMP cells could be innovative therapies for ptosis and sphincter dysfunction of the anal and the urethra.
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