| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
We established Tie2Cre;Ai14;COL-EGFP mice in which Tie2-expressing cells were genetically marked with tdTomato and collagen type1-expressing cells expressed EGFP. Using the transgenic mice, we made hypertrophic scar models and normal scar models, and analyzed the scars with immunofluorescent imaging.
In the normal scars, tdTomato-positive cells (tdT-cells) did not express EGFP, suggesting tdT-cells did not produce collagen type 1. In the other hand, tdT-cells in the hypertrophic scars partially expressed EGFP, suggesting tdT-cells contributed to dermal fibrosis.
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