A polymorphysm in the IL-6 promotor region associated with the keloid in the Japanease population
| Project/Area Number |
24592723
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Nippon Medical School |
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Principal Investigator |
MAMIKO Tosa 日本医科大学, 医学部, 講師 (30301568)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Atsushi 日本医科大学, 医学部, 准教授 (10307952)
GHAZIZADEH M 日本医科大学, 付置研究所, 准教授 (30190979)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | ケロイド / ＩＬ－６ / ＳＮＰ / 遺伝子解析 / IL-6 / SNP / 遺伝子 / 一塩基多型 |
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| Outline of Final Research Achievements |
Keloid develops as an abnormal wound healing lesion in genetically predisposed individuals.IL-6 is involved in both cell proliferation and collagen synthesis. We previously reported up-regulation of the IL-6 and its involvement in the pathogenesis of keloid. In this study, we investigated whether SNPs in the IL-6 promoter region or IL-6 receptor (IL-6R) gene might be associated with keloid and if so its relationship with clinical severity of the disease.
The IL-6 -572G/C polymorphism was significantly associated with keloid in general and clinical severity of keloid in particular, thus suggesting a potential role for the IL-6 promoter SNP analysis in predicting the susceptibility to keloid formation and facilitating therapeutic managements.
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Report
(4 results)
Research Products
(5 results)
