| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Outline of Final Research Achievements |
Keloid develops as an abnormal wound healing lesion in genetically predisposed individuals.IL-6 is involved in both cell proliferation and collagen synthesis. We previously reported up-regulation of the IL-6 and its involvement in the pathogenesis of keloid. In this study, we investigated whether SNPs in the IL-6 promoter region or IL-6 receptor (IL-6R) gene might be associated with keloid and if so its relationship with clinical severity of the disease.
The IL-6 -572G/C polymorphism was significantly associated with keloid in general and clinical severity of keloid in particular, thus suggesting a potential role for the IL-6 promoter SNP analysis in predicting the susceptibility to keloid formation and facilitating therapeutic managements.
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