Enhanced glucose metabolism improves cardiac function and survival rate during severe sepsis

• Project/Area Number: 24592730
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Gunma University
• Principal Investigator: KUNIMOTO Fumio 群馬大学, 医学部附属病院, 准教授 (70125847)
• Co-Investigator(Kenkyū-buntansha): ISO Tatsuya 群馬大学, 大学院医学系研究科, 准教授 (10400756)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 敗血症 / 心不全 / エネルギー代謝 / 脂肪酸 / グルコース / 糖代謝 / 脂肪酸代謝 / 心機能 / FABP4 / FABP5 / ノックアウトマウス

Outline of Final Research Achievements

Severe sepsis induces systemic insulin resistance and multiple organ failure including heart failure. We studied whether a shift of energy substrates from FA to glucose independently of insulin affects cardiac function in sepsis using a mouse model in which glucose uptake is markedly increased independent of insulin. Cardiac dysfunction induced by intraperitoneal injection of lipopolysaccharide was deteriorated in this model compared with control mice. Importantly, energy storage such as triacylglycerol and glycogen was markedly increased despite of a reduction in uptake of fatty acid and glucose into hearts in both mice. These findings suggest that enhancement of glucose uptake into heart is not promising strategy for treatment of cardiac dysfunction in sepsis.

Research Products

• [Journal Article] Extremely Low Levels of Serum Uric Acid Are Associated With Endothelial Dysfunction in Humans. (2015)
  • Author(s): Iso T, Kurabayashi M.
  • Journal Title: Circ J. Volume: -
  • NAID: 130005066275
  • Open Access
• [Journal Article] CD36 is indispensable for thermogenesis under conditions offasting and cold stress. (2015)
  • Author(s): Putri M, Syamsunarno MR, Iso T, Yamaguchi A, Hanaoka H, Sunaga H, Koitabashi N, Matsui H, Yamazaki C, Kameo S, Tsushima Y, Yokoyama T, Koyama H, Abumrad NA, Kurabayashi M.
  • Journal Title: Biochem Biophys Res Commun. Volume: 457 Issue: 4 Pages: 520-525
  • DOI: 10.1016/j.bbrc.2014.12.124
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 毛細血管内皮細胞を介する心筋・骨格筋の脂肪酸代謝の制御機構と全身代謝への影響 (2015)
  • Author(s): 磯達也、倉林正彦
  • Journal Title: Annual Review 2015 糖尿病・代謝・内分泌（中外医学社） Volume: - Pages: 98-104
• [Journal Article] Fatty Acid Binding Protein 4 and 5 Play a Crucial Role in Thermogenesis under the Conditions of Fasting and Cold Stress (2014)
  • Author(s): Syamsunarno MR, Matsui H, 他12名
  • Journal Title: PLoS ONE Volume: 9(3) Issue: 3 Pages: 90825-90825
  • DOI: 10.1371/journal.pone.0090825
  • Peer Reviewed / Open Access
• [Journal Article] 毛細血管内皮細胞を介する脂肪酸代謝の制御機構とPPARの役割 (2014)
  • Author(s): 磯達也、倉林正彦
  • Journal Title: 内分泌・糖尿病・代謝内科（科学評論社） Volume: 39 Pages: 449-454
• [Journal Article] 筋型毛細血管内皮細胞を介する心筋脂肪酸代謝の制御機構 (2014)
  • Author(s): 磯達也、倉林正彦
  • Journal Title: 月刊 細胞（ニューサイエンス社） Volume: 46 Pages: 303-306
• [Journal Article] 神経芽腫、肝腫瘍による腹部コンパートメント症候群に対する周術期管理の1症例 (2014)
  • Author(s): 柳澤 晃広, 戸部 賢, 日野原 宏, 国元 文生, 高澤 知規, 齋藤 繁
  • Journal Title: 麻酔 Volume: 63 Pages: 184-187
  • Peer Reviewed
• [Journal Article] Deranged fatty acid composition causes pulmonary fibrosis in Elovl6-deficient mice (2013)
  • Author(s): Sunaga Hiroaki, Kurabayashi Masahiko
  • Journal Title: Nature Communications Volume: vol.4 Issue: 1 Pages: 2563-2563
  • DOI: 10.1038/ncomms3563
  • Peer Reviewed
• [Journal Article] A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting (2013)
  • Author(s): Syamsunarno MR, Iso T, Hanaoka H, Yamaguchi A, Obokata M, Koitabashi N, Goto K, Hishiki T, Nagahata Y, Matsui H, Sano M, Kobayashi M, Kikuchi O, Sasaki T, Maeda K, Murakami M, Kitamura T, Suematsu M, Tsushima Y, Endo K, Hotamisligil GS, Kurabayashi M
  • Journal Title: PLoS One Volume: 14;8 Issue: 11 Pages: e79386-e79386
  • DOI: 10.1371/journal.pone.0079386
  • Peer Reviewed
• [Journal Article] Capillary endothelial fatty acid binding proteins 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle (2013)
  • Author(s): Iso Tatsuya, Kurabayashi Masahiko
  • Journal Title: Arteriosclerosi Thrombosis and Vascular Biology Volume: vol.33 Issue: 11 Pages: 2549-2557
  • DOI: 10.1161/atvbaha.113.301588
  • Peer Reviewed
• [Journal Article] 【今知りたい!集中治療の最新論点-Pro & Conディベート-】 栄養 栄養管理に中心静脈栄養法は不要である? (2013)
  • Author(s): 巽 博臣, 今泉 均, 升田 好樹, 吉田 真一郎, 坂脇 英志, 後藤 京子, 高橋 科那子, 山蔭 道明, 大川 牧生, 国元 文生
  • Journal Title: 救急・集中治療 Volume: 25 Pages: 1194-1200
  • Peer Reviewed
• [Journal Article] Comparative effects of flurbiprofen and fentanyl on natural killer cell cytotoxicity, lymphocyte subsets and cytokine concentrations in post-surgical intensive care unit patients: prospective, randomized study. (2013)
  • Author(s): Narahara H, Kadoi Y, Hinohara H, Kunimoto F, Saito S.
  • Journal Title: Journal of Anesthesia Volume: 27 Issue: 5 Pages: 676-683
  • DOI: 10.1007/s00540-013-1597-5
  • Peer Reviewed
• [Journal Article] 乳癌の抗癌薬によるアナフィラキシー様反応により呼吸不全を生じ、ECMO使用により救命できた1例 (2013)
  • Author(s): 柳澤 晃広,金本 匡史,久保 和弘,日野原 宏, 国元 文生,齋藤 繁
  • Journal Title: 臨床麻酔 Volume: 37
  • Peer Reviewed
• [Journal Article] Perioperative nutriture in esophageal cancer patients undergoing esophagectomy. (2013)
  • Author(s): Kobayashi T, Oshima K, Yokobori T, Idetsu A, Hayashi Y, Hinohara RN, Miyazaki T, Kunimoto F, Kato H, Kuwano H.
  • Journal Title: Hepatogastroenterology Volume: 60 Pages: 1311-6
  • Peer Reviewed
• [Journal Article] PPARgamma in Capillary Endothelia Promotes Fatty Acid Uptake by Heart During Long-term Fasting. (2013)
  • Author(s): Goto K, Iso T, Hanaoka H, Suga T, Hattori A, Irie Y, Shinagawa Y, Matsui H, Syamsunarno MRAA, Matsui M, Haque A, Arai M, Kunimoto F, Yokoyama T, Endo K, Gonzalez FJ, Kurabayashi M.
  • Journal Title: J Am Heart Assoc. Volume: 2(1)
  • Peer Reviewed
• [Journal Article] 術後の血管系合併症-その診断と対策 術後の肺動脈塞栓 治療のコツ (2013)
  • Author(s): 猪瀬崇徳,宮崎達也,鈴木茂正,田中成岳,国元文生,桑野博行
  • Journal Title: 臨床外科 Volume: 68（2） Pages: 158-163
  • Peer Reviewed
• [Journal Article] Stearoyl-CoA Desaturase-1 (SCD1) Augments Saturated Fatty Acid-Induced Lipid Accumulation and Inhibits Apoptosis in Cardiac Myocytes. (2012)
  • Author(s): Matsui H, Yokoyama T, Sekiguchi K, Iijima D, Sunaga H, Maniwa M, Ueno M, Iso T, Arai M, Kurabayashi M.
  • Journal Title: PLoS One. Volume: 7(3)
  • Peer Reviewed
• [Journal Article] Azelnidipine inhibits Msx2-dependent osteogenic differentiation and matrix mineralization of vascular smooth muscle cells. (2012)
  • Author(s): Shimizu T, Tanaka T, Iso T, Kawai-Kowase K, Kurabayashi M.
  • Journal Title: Int Heart J. Volume: 53(5) Pages: 331-335
  • NAID: 130001914171
  • Peer Reviewed
• [Journal Article] Necrotizing fasciitis following psoas muscle abscess caused by hypermucoviscous Klebsiella pneumoniae. (2012)
  • Author(s): Mita N, Narahara H, Okawa M, Hinohara H, Kunimoto F, Haque A, Saito S, Oshima K.
  • Journal Title: J Infect Chemother Volume: 18(4) Pages: 565-8
  • NAID: 10030948251
  • Peer Reviewed
• [Journal Article] ICU患者における血清マグネシウムイオン値と重症度の関連 (2012)
  • Author(s): 楢原創,金本匡史,大川牧生,日野原宏,国元文生,齋藤繁
  • Journal Title: ICUとCCU Volume: 36（6） Pages: 445-450
  • Peer Reviewed
• [Presentation] Deletion of Fatty Acid Binding Protein-4 and -5 Exacerbate Cardiac Dysfunction Because of Insufficient ATP production during Pressure Overload in Mice. (2014)
  • Author(s): Syamsunarno MRAA, Iso T, Koitabashi N, Kurabayashi M.
  • Organizer: 第31回 国際心臓研究学会（ISHR）日本部会
  • Place of Presentation: 名古屋（ウィンクあいち）
  • Year and Date: 2014-11-28 – 2014-11-29
• [Presentation] Deletion of Fatty Acid Binding Protein-4 and -5 Exacerbate Cardiac Dysfunction Because of Insufficient ATP Production during Pressure Overload in Mice. (2014)
  • Author(s): Syamsunarno MRAA, Iso T, Koitabashi N, Kurabayashi M.
  • Organizer: The 87th annual meeting of American Heart Association
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-14 – 2014-11-19
• [Presentation] Deficiency of Fatty Acid Binding Protein-4 and -5 Impairs Intestinal Lipid Absorption. (2014)
  • Author(s): Syamsunarno MRAA, Iso T, Kurabayashi M.
  • Organizer: The 87th annual meeting of American Heart Association
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-14 – 2014-11-19
• [Presentation] Long Chain Fatty Acid Composition Modulated by Elovl6 Plays a Critical Role in Vascular Smooth Muscle Cell Proliferation and Neointimal Formation. (2014)
  • Author(s): Matsui H, Sunaga H, Anjo S, Syamsunarno MRAA, Iso T, Matsuzaka T, Shimano H, Yokoyama T, Kurabayashi M.
  • Organizer: The 87th annual meeting of American Heart Association
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-14 – 2014-11-19
• [Presentation] Early Increase in Serum Fatty Acid Binding Protein 4 Levels in Patients with Acute Myocardial Infarction: Lipolysis as a Novel Marker for Myocardial Ischemia. (2014)
  • Author(s): Sunaga H, Ohyama Y, Obokata M, Iso T, Kawaguchi T, Koitabashi N, Funada R, Takama N, Syamsunarno MRAA, Matsui H, Yokoyama T, Kurabayashi M.
  • Organizer: The 87th annual meeting of American Heart Association
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-14 – 2014-11-19
• [Presentation] 筋型毛細血管内皮細胞を介する心筋・骨格筋の脂肪酸代謝の制御機構と全身代謝への影響 (2014)
  • Author(s): １３．磯達也、Mas Rizky、倉林正彦
  • Organizer: 第35回 日本肥満学会
  • Place of Presentation: 宮崎（シーガイアコンベンションセンター）
  • Year and Date: 2014-10-24 – 2014-10-25
  • Invited
• [Presentation] 心血管イベント時のダイナミックな血中FABP4濃度変化のメカニズムの解明 (2014)
  • Author(s): １４．須永 浩章, 磯 達也, 河口智香, 小板橋紀通, 松井 弘樹, 横山 知行, 倉林 正彦
  • Organizer: 第46回 日本動脈硬化学会総会・学術集会
  • Place of Presentation: 東京（京王プラザホテル）
  • Year and Date: 2014-07-10 – 2014-07-11
• [Presentation] 脂肪酸伸長酵素Elovl6は血管平滑筋細胞の脂肪酸組成を調節することで増殖に関与する (2014)
  • Author(s): １５．須永 浩章, 松井 弘樹, 安生 早紀, 磯 達也, 松坂 賢, 島野 仁, 横山 知行, 倉林 正彦
  • Organizer: 第46回 日本動脈硬化学会総会・学術集会
  • Place of Presentation: 東京（京王プラザホテル）
  • Year and Date: 2014-07-10 – 2014-07-11
• [Presentation] Fatty Acid Binding Protein 4 is a target gene of Dll4-Notch1 pathway in Capillary Endothelial Cells in Heart. (2014)
  • Author(s): １６．Tatsuya Iso, Tomoka Kawaguchi, Naoto Yajima, Hiroki Matsui, Tomoyuki Yokayama, Masahiko Kurabayashi.
  • Organizer: 第46回 日本動脈硬化学会総会・学術集会
  • Place of Presentation: 東京（京王プラザホテル）
  • Year and Date: 2014-07-10 – 2014-07-11
• [Presentation] Fatty acid binding protein 4 and 5 are involved in formation of abodominal aortic aneurysm created by CaCl2 in mice. (2014)
  • Author(s): １７．Tatsuya Iso, Tomoaki Ishii, Hiroki Matsui, Tomoyuki Yokoyama, Masahiko Kurabayashi.
  • Organizer: 第46回 日本動脈硬化学会総会・学術集会
  • Place of Presentation: 東京（京王プラザホテル）
  • Year and Date: 2014-07-10 – 2014-07-11
• [Presentation] Differential expression of FABP4 and FABP5 isoforms in macrophages during the development of atherosclerosis. (2014)
  • Author(s): １８．Tatsuya Iso, Aiko Enoura, Harumi Ogura, Hiroki Matsui, Tomoyuki Yokoyama, Masahiko Kurabayashi.
  • Organizer: 第46回 日本動脈硬化学会総会・学術集会
  • Place of Presentation: 東京（京王プラザホテル）
  • Year and Date: 2014-07-10 – 2014-07-11
• [Presentation] Fatty acid binding protein 4 and 5 play a crucial role in adaptive response to prolonged fasting and cold exposure in mice. (2014)
  • Author(s): Mas Rizky A.A Syamsunarno, Tatsuya Iso, Masahiko Kurabayashi.
  • Organizer: The 18th International Vascular Biology Meeting
  • Place of Presentation: Miyakomesse, Kyoto
  • Year and Date: 2014-04-14 – 2014-04-17
• [Presentation] Effects of long chain fatty acid composition regulated by Elovl6 on the proliferation of vascular smooth muscle cells. (2014)
  • Author(s): Hiroki Matsui, Hiroaki Sunaga, Saki Anjo, Tatsuya Iso, Tomoyuki Yokoyama, Masahiko Kurabayashi.
  • Organizer: The 18th International Vascular Biology Meeting
  • Place of Presentation: Miyakomesse, Kyoto
  • Year and Date: 2014-04-14 – 2014-04-17
• [Presentation] Circulating FABP4 is released from adipocytes and capillary endothelial cells by sympathetic activation via β3 receptor during acute cardiovascular event. (2014)
  • Author(s): Hiroaki Sunaga, Tatsuya Iso, Tomoka Kawaguchi, Mas Rizky Syamsunarno, Hiroki Matsui, Yoshiaki Ohyama, Tomoyuki Yokoyama, Masahiko Kurabayashi.
  • Organizer: The 18th International Vascular Biology Meeting
  • Place of Presentation: Miyakomesse, Kyoto
  • Year and Date: 2014-04-14 – 2014-04-17
• [Presentation] Differential expression of FABP4 and FABP5 isoforms in macrophages during the development of atherosclerosis. (2014)
  • Author(s): Tatsuya Iso, Aiko Enoura, Harumi Ogura, Hiroki Matsui, Tomoyuki Yokoyama, Masahiko Kurabayashi.
  • Organizer: The 18th International Vascular Biology Meeting
  • Place of Presentation: Miyakomesse, Kyoto
  • Year and Date: 2014-04-14 – 2014-04-17
• [Presentation] Fatty acid binding protein 4 and 5 are involved in formation of abodominal aortic aneurysm created by CaCl2 in mice. (2014)
  • Author(s): Tatsuya Iso, Tomoaki Ishii, Hiroaki Sunaga, Mas Rizky A.A Syamsunarno, Hiroki Matsui, Norimichi Koitabashi, Tomoyuki Yokoyama, Masahiko Kurabayashi.
  • Organizer: The 18th International Vascular Biology Meeting
  • Place of Presentation: Miyakomesse, Kyoto
  • Year and Date: 2014-04-14 – 2014-04-17
• [Presentation] Fatty Acid Binding Protein 4 is a direct target gene of Dll4-Notch1 pathway in Capillary Endothelial Cells in Heart. (2014)
  • Author(s): Tatsuya Iso, Tomoka Kawaguchi, Naoto Yajima, Hiroki Matsui, Tomoyuki Yokayama, Masahiko Kurabayashi.
  • Organizer: The 18th International Vascular Biology Meeting
  • Place of Presentation: Miyakomesse, Kyoto
  • Year and Date: 2014-04-14 – 2014-04-17
• [Presentation] Glucose Uptake in the Heart of FABP4/5 double knockout mice is Promoted by Allosteric and Post-transcriptional Regulation of Glycolytic Pathways. (2014)
  • Author(s): Tatsuya Iso, Kazuhisa Maeda, Hirofumi Hanaoka, Kosaku Goto, Mas Rizky A.A Syamsunarno, Takako Hishiki, Yoshiko Nagahata, Hiroki Matsui, Masashi Arai, Aiko Yamaguchi, Motoaki Sano, Makoto Suematsu, Keigo Endo, Gökhan S. Hotamisligil and Masahiko Kurabayashi.
  • Organizer: The 18th International Vascular Biology Meeting
  • Place of Presentation: Miyakomesse, Kyoto
  • Year and Date: 2014-04-14 – 2014-04-17
• [Presentation] Fatty Acid Binding Protein 4 and -5 Play a Crucial Role in Theromogenesis under Cold Stress during Fasting. (2014)
  • Author(s): Mas R.A.A. Syamsunarno ,Iso T, Mirasari Putri , Yamaguchi A, Kurabayashi M.
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] ICU患者の急性期投与エネルギー量は20～25kcal/kgも必要ない (2014)
  • Author(s): 国元文生
  • Organizer: 第41回日本集中治療医学会学術集会
  • Place of Presentation: 京都
  • Invited
• [Presentation] Oral Assesment Sheetを用いた口腔ケア回診での口腔スコアの経時的変化と課題 (2014)
  • Author(s): 福士宙之,神山治郎,柳澤晃広,河内奈穂美,楢原創,金本匡史,戸部賢,日野原宏,根岸明秀,国元文生
  • Organizer: 第41回日本集中治療医学会学術集会
  • Place of Presentation: 京都
• [Presentation] Fatty acid binding protein 4 and 5 play a crucial role in adaptive response to prolonged fasting and cold exposure in mice. (2013)
  • Author(s): Syamsunarno MRAA, Tatsuya Iso, Masahiko Kurabayashi.
  • Organizer: Annual meeting of American Heart Association
  • Place of Presentation: Dallas, USA
• [Presentation] A protective role of Fibroblast growth factor 23 against vascular calcification. (2013)
  • Author(s): Nakahara T, Keiko Kawai-Kowase, Hiroki Matsui, Tatsuya Iso、Toshihiro Utsugi, Shoichi Tomono, Masashi Arai, Masahiko Kurabayashi.
  • Organizer: Annual meeting of American Heart Association
  • Place of Presentation: Dallas, USA
• [Presentation] Association between serum FABP4 levels, pericardial adipose tissue volume, and plaque characteristics in patients with type 2 diabetes mellitus. (2013)
  • Author(s): Nakahara T, Keiko Kawai-Kowase,Rieko Nakahara,Toshihiro Utsugi, Tatsuya Iso, Masashi Arai, Shoichi Tomono, Yoshito Tsushima, Masami Murakami, Masahiko Kurabayashi.
  • Organizer: Annual meeting of American Heart Association
  • Place of Presentation: Dallas, USA
• [Presentation] Capillary endothelial fatty acid binding protein 4 and 5 are required for sufficient energy production in the heart. (2013)
  • Author(s): Tatsuya Iso, Masahiko Kurabayashi.
  • Organizer: European Society of Cardiology Congress
  • Place of Presentation: Amsterdam, Netherlands
• [Presentation] Evidence for a Protective Role of Fibroblast Growth Factor 23 against Vascular Calcification. (2013)
  • Author(s): Nakahara T, Kowase K, Matsui h, Iso T, Utsugi O, Tomono S, Ogawa A, Kanesawa N, Kurabayashi M.
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Serum FABP4 Levels are Associated with Pericardial Adipose Tissue Volume and Plaque Characteristics in Patients with Type 2 Diabetes Mellitus. (2013)
  • Author(s): Nakahara T, Kowase K, Nakahara R, Utsugi T, Iso T, Tomono S, Tsushima Y, Murakami M , Kurabayashi M.
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Differential Release Kinetic of Serum FABP3, FABP4 and FABP5 in the Patients with Acute Coronary Syndrome. (2013)
  • Author(s): Obokata M, Iso T, Ohyama Y, Murata M, Matsuo Y, Sano H, Funada R, Takama N, Koitabashi N, Nakajima T, Kaneko Y, Kurabayashi M.
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Fatty Acid Binding Protein-4 and -5 are Expressed in Intestinal Capillary Endothelial Cells and Regulate Lipid Absorption. (2013)
  • Author(s): Mas R.A.A. Syamsunarno , Iso T, Kurabayashi M.
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Effects of Long Chain Fatty Acid Composition Regulated by Elovl6 on the Proliferation of Vascular Smooth Muscle Cells. (2013)
  • Author(s): Anjo S, Matsui H, Sunaga H, Iso T, Kurabayashi M, Yokoyama T.
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Fatty Acid Binding Protein 4 and 5 Differentially Regulate Formation of Abdominal Aortic Aneurysm Induced by Calcium Chloride in Mice. (2013)
  • Author(s): Ishii T, Iso T, Sunaga H,2Mas Rizky Syamsunarno , Matsui H, Koitabashi N, Yokoyama T, Kurabayashi M.
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Fatty Acid Binding Protein 4 is a Direct Target Gene of Dll4-Notch1 Pathway in Capillary Endothelial Cells in Heart. (2013)
  • Author(s): Kawaguchi T, Iso T, Yajima N, Matsui H, Yokoyama T, Kurabayash M.
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Circulating FABP4 is Released from Adipocytes and Capillary Endothelial Cells by Sympathetic Activation via β3 Receptor during Acute Cardiovascular Event. (2013)
  • Author(s): Kawaguchi T, Iso T, Sunaga H, Mas Rizky A.A Syamsunarno, Matsui H, Ohyama Y, Yokoyama T, Kurabayashi M.
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Fatty acid binding protein 4 and 5 play a crucial role in adaptive response to prolonged fasting and cold exposure in mice. (2013)
  • Author(s): Mas Rizky A.A Syamsunarno, Tatsuya Iso, Masahiko Kurabayashi.
  • Organizer: 第17回 日本心血管内分泌代謝学会
  • Place of Presentation: 大阪
• [Presentation] 筋型毛細血管内皮細胞に発現するＦＡＢＰ４／５は絶食時の全身の代謝適応に重要な役割を果たす (2013)
  • Author(s): 磯 達也
  • Organizer: 第34回 日本肥満学会
  • Place of Presentation: 東京
• [Presentation] Notchシグナルによる血管細胞の分化制御 (2013)
  • Author(s): 磯 達也
  • Organizer: 第21回 日本血管生物医学会
  • Place of Presentation: 大阪
  • Invited
• [Presentation] プロカルシトニン（PCT）値と各種細菌培養結果との検討 (2013)
  • Author(s): 柳澤晃広,福士宙之,神山治郎,楢原創,金本匡史,久保和宏,戸部賢,日野原宏,門井雄司,国元文生,齋藤繁
  • Organizer: 第22回日本集中治療医学会関東甲信越地方会
  • Place of Presentation: 筑波
• [Presentation] Capillary endothelial Fatty Acid Binding Protein 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle. (2013)
  • Author(s): Tatsuya Iso
  • Organizer: 第90回 日本生理学会大会
  • Place of Presentation: 東京
• [Presentation] Glucose Uptake in the Heart of FABP4/5 Double Knockout Mice is Promoted by Allosteric and Post-transcriptional Regulation of Glycolytic Pathways (2013)
  • Author(s): Tatsuya Iso, Hiroki Matsui, Motoaki Sano, Takako Hishiki, Yoshiko Nagahata, Makoto Suematsu, Masahiko Kurabayashi
  • Organizer: 第77回 日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Defective Fatty Acid Uptake through Capillary Endothelial Cells of Heart and Skeletal Muscle Induces Prominent Fatty Liver (2013)
  • Author(s): Mas Rizky A.A Syamsunarno, Tatsuya Iso, Masahiko Kurabayashi
  • Organizer: 第77回 日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Detrimental effects of FABP4 and FABP5 Deletion on Hepatic Energy Metabolism after Prolonged Fasting (2013)
  • Author(s): Mas Rizky A.A Syamsunarno, Tatsuya Iso, Masahiko Kurabayashi
  • Organizer: 第77回 日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Differential Expression of FABP4 and FABP5 Isoforms in Macrophages during the Development of Atherosclerosis (2013)
  • Author(s): Aiko Enoura,Tatsuya Iso, Harumi Ogura, Hiroki Matsui, Tomoyuki Yokoyama, Masahiko Kurabayashi
  • Organizer: 第77回 日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] GPIHBP1, an Endothelial Binding Site for Lipoprotein Lipase and Chylomicrons, is Induced by Peroxisome proliferator-activated receptor- ϒ in Cardiac Fibroblasts (2013)
  • Author(s): Hiroaki Takahashi., Tatsuya Iso, Hiroki Matsui, Tomoyuki Yokoyama, Masahiko Kurabayashi
  • Organizer: 第77回 日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Circulating Fatty Acid Binding Protein 4 is an early marker for Acute Myocardial Infarction (2013)
  • Author(s): Yoshiaki Ohyama, Tatsuya Iso, Kuniko Masuda, Shuntaro Tamura, Makoto Murata, Kosaku Goto, Ryuichi Funada, Norimichi Koitabashi, Noriaki Takama, Masahi Arai, Masahiko Kurabayashi
  • Organizer: 第77回 日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Differential Time-dependent Changes in Fatty Acid Binding Protein Isoforms Levels in Patients with Acute Myocardial Infarction and Acute Heart Failure (2013)
  • Author(s): Yoshiaki Ohyama, Tatsuya Iso, Kuniko Masuda, Shuntaro Tamura, Makoto Murata, Kosaku Goto, Ryuichi Funada, Norimichi Koitabashi, Noriaki Takama, Masahi Arai, Masahiko Kurabayashi
  • Organizer: 第77回 日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Fibroblast growth factor 23 inhibits osteogenic differentiation of vascular smooth muscle cells: A protective role against vascular calcification. (2013)
  • Author(s): Takehiro Nakahara, Keiko Kawai-Kowase, Hiroki Matsui, Tatsuya Iso, Toshihiro Utsugi, Shoichi Tomono,Ogawa A., Norio Kanesawa, Masashi Arai, Kurabayashi M.
  • Organizer: 第77回 日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Quantification of Cardiac Energetic Substrates in the Development of Heart Failure Induced by Pressure-overload in Mice (2013)
  • Author(s): Norimichi Koitabashi, Masaru Obokata, Aiko Yamaguchi, Mas Rizky A.A Syamsunarno, Kosaku Goto, Tatsuya Iso, Masashi Arai, Hirofumi Hanaoka, Yoshito Tsushima, Masahiko Kurabayashi
  • Organizer: 第77回 日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] 塩酸ピルジカイニド中毒により心室頻拍を呈した1例 (2013)
  • Author(s): 村田将人,萩原周一,金子稔,青木誠,古川和美,中村卓郎,大山良雄,田村遵一,国元文生,大嶋清宏
  • Organizer: 第40回 日本集中治療医学会学術集会
  • Place of Presentation: 松本
• [Presentation] L-FABPによる腎機能低下の早期診断における有用性 (2013)
  • Author(s): 柳澤晃広,楢原創,金本匡史,大川牧生,戸部賢,高澤知規,日野原宏,門井雄司,国元文生,齋藤繁
  • Organizer: 第40回 日本集中治療医学会学術集会
  • Place of Presentation: 松本
• [Presentation] 重症患者栄養管理のエビデンスとプラクティス (2013)
  • Author(s): 国元文生
  • Organizer: 第40回 日本集中治療医学会学術集会
  • Place of Presentation: 松本
• [Presentation] Fatty Acid Binding Protein 4 and Fatty Acid Translocase are Induced by Notch Signaling via Induction of PPARγ in Capillary Endothelial Cells in Heart After Long Time Fasting (2012)
  • Author(s): Tatsuya Iso, Naoto Yajima, Tomoka Kawaguchi, Kyosuke Takeshita, Hiroki Matsui, Kosaku Goto, Tomoyuki Yokoyama, Masahiko Kurabayashi.
  • Organizer: Annual meeting of American Heart Association
  • Place of Presentation: Los Angeles, USA
• [Presentation] Long-Chain Fatty Acid Elongase, Elovl6, is Crucial for Vascular Smooth Muscle Cell Proliferation Underlying Neointimal Hyperplasia (2012)
  • Author(s): Hiroaki Sunaga, Hiroki Matsui, Tomoyuki Yokoyama, Saki Anjo, Tatsuya Iso, Masahiko Kurabayashi
  • Organizer: Annual meeting of American Heart Association
  • Place of Presentation: Los Angeles, USA
• [Presentation] Fibroblast Growth Factor 23 Inhibits Osteogenic Differentiation of Vascular Smooth Muscle Cells: A Protective Role Against Vascular Calcification. (2012)
  • Author(s): Takehiro Nakahara, Keiko Kawai-Kowase, Hiroki Matsui, Tatsuya Iso, Toshihiro Utsugi, Shoichi Tomono, Masashi Arai, Masahiko Kurabayashi
  • Organizer: Annual meeting of American Heart Association
  • Place of Presentation: Los Angeles, USA
• [Presentation] Glucose uptake in the heart of mice doubly deficient for FABP4/5 is dramatically promoted by allosteric and post-transcriptional regulation independently of insulin (2012)
  • Author(s): Tatsuya Iso, Kazuhisa Maeda, Hirofumi Hanaoka, Mas Rizky, Takako Hishiki, Hiroki Matsui, Aiko Yamaguchi, Makoto Suematsu, Gokhan S. Hotamisligil, Masahiko Kurabayashi
  • Organizer: 第29回国際心臓研究学会（ISHR）日本部会総会
  • Place of Presentation: 福岡
• [Presentation] FABP4 and FAT/CD36 are induced by Notch Signaling via Induction of PPARgamma in Capillary Endothelial Cells in Heart after long time fasting (2012)
  • Author(s): Tatsuya Iso, Naoto Yajima, Kyosuke Takeshita, Hiroki Matsui, Kosaku Goto, Tomoyuki Yokayama, Masahiko Kurabayashi
  • Organizer: 第29回国際心臓研究学会（ISHR）日本部会総会
  • Place of Presentation: 福岡
• [Presentation] PPARgamma in Capillary Endothelia Promotes Fatty Acid Uptake by Heart During Long-term Fasting (2012)
  • Author(s): Kosaku Goto, Tatsuya Iso, Hirofumi Hanaoka, Frank Gonzalez, Masahiko Kurabayashi
  • Organizer: 第29回国際心臓研究学会（ISHR）日本部会総会
  • Place of Presentation: 福岡
• [Book] 血管新生研究の最先端 「Notchシグナル」 (2013)
  • Author(s): 磯 達也
  • Total Pages: 7
  • Publisher: 医薬ジャーナル社
• [Remarks] 群馬大学大学院医学系研究科 臓器病態内科学 循環器内科 基礎研究 磯グループ
  • URL: http://gunma-u-med2.jp/%E5%8C%BB%E7%99%82%E3%82%B0%E3%83%AB%E3%83%BC%E3%83%97/%E5%8C%BB%E7%99%82%E3%82%B0%E3%83%AB%E3%83%BC%E3%83%97-%E5%BE%AA%E7%92%B0%E5%99%A8%E5%86%85%E7%A7%91/