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Enhanced glucose metabolism improves cardiac function and survival rate during severe sepsis

Research Project

Project/Area Number 24592730
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Emergency medicine
Research InstitutionGunma University

Principal Investigator

KUNIMOTO Fumio  群馬大学, 医学部附属病院, 准教授 (70125847)

Co-Investigator(Kenkyū-buntansha) ISO Tatsuya  群馬大学, 大学院医学系研究科, 准教授 (10400756)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords敗血症 / 心不全 / エネルギー代謝 / 脂肪酸 / グルコース / 糖代謝 / 脂肪酸代謝 / 心機能 / FABP4 / FABP5 / ノックアウトマウス
Outline of Final Research Achievements

Severe sepsis induces systemic insulin resistance and multiple organ failure including heart failure. We studied whether a shift of energy substrates from FA to glucose independently of insulin affects cardiac function in sepsis using a mouse model in which glucose uptake is markedly increased independent of insulin. Cardiac dysfunction induced by intraperitoneal injection of lipopolysaccharide was deteriorated in this model compared with control mice. Importantly, energy storage such as triacylglycerol and glycogen was markedly increased despite of a reduction in uptake of fatty acid and glucose into hearts in both mice. These findings suggest that enhancement of glucose uptake into heart is not promising strategy for treatment of cardiac dysfunction in sepsis.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (78 results)

All 2015 2014 2013 2012 Other

All Journal Article (20 results) (of which Open Access: 3 results,  Peer Reviewed: 16 results,  Acknowledgement Compliant: 1 results) Presentation (56 results) (of which Invited: 3 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Extremely Low Levels of Serum Uric Acid Are Associated With Endothelial Dysfunction in Humans.2015

    • Author(s)
      Iso T, Kurabayashi M.
    • Journal Title

      Circ J.

      Volume: -

    • NAID

      130005066275

    • Related Report
      2014 Annual Research Report
    • Open Access
  • [Journal Article] CD36 is indispensable for thermogenesis under conditions offasting and cold stress.2015

    • Author(s)
      Putri M, Syamsunarno MR, Iso T, Yamaguchi A, Hanaoka H, Sunaga H, Koitabashi N, Matsui H, Yamazaki C, Kameo S, Tsushima Y, Yokoyama T, Koyama H, Abumrad NA, Kurabayashi M.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 457 Issue: 4 Pages: 520-525

    • DOI

      10.1016/j.bbrc.2014.12.124

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 毛細血管内皮細胞を介する心筋・骨格筋の脂肪酸代謝の制御機構と全身代謝への影響2015

    • Author(s)
      磯達也、倉林正彦
    • Journal Title

      Annual Review 2015 糖尿病・代謝・内分泌(中外医学社)

      Volume: - Pages: 98-104

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Fatty Acid Binding Protein 4 and 5 Play a Crucial Role in Thermogenesis under the Conditions of Fasting and Cold Stress2014

    • Author(s)
      Syamsunarno MR, Matsui H, 他12名
    • Journal Title

      PLoS ONE

      Volume: 9(3) Issue: 3 Pages: 90825-90825

    • DOI

      10.1371/journal.pone.0090825

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 毛細血管内皮細胞を介する脂肪酸代謝の制御機構とPPARの役割2014

    • Author(s)
      磯達也、倉林正彦
    • Journal Title

      内分泌・糖尿病・代謝内科(科学評論社)

      Volume: 39 Pages: 449-454

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 筋型毛細血管内皮細胞を介する心筋脂肪酸代謝の制御機構2014

    • Author(s)
      磯達也、倉林正彦
    • Journal Title

      月刊 細胞(ニューサイエンス社)

      Volume: 46 Pages: 303-306

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 神経芽腫、肝腫瘍による腹部コンパートメント症候群に対する周術期管理の1症例2014

    • Author(s)
      柳澤 晃広, 戸部 賢, 日野原 宏, 国元 文生, 高澤 知規, 齋藤 繁
    • Journal Title

      麻酔

      Volume: 63 Pages: 184-187

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Deranged fatty acid composition causes pulmonary fibrosis in Elovl6-deficient mice2013

    • Author(s)
      Sunaga Hiroaki, Kurabayashi Masahiko
    • Journal Title

      Nature Communications

      Volume: vol.4 Issue: 1 Pages: 2563-2563

    • DOI

      10.1038/ncomms3563

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting2013

    • Author(s)
      Syamsunarno MR, Iso T, Hanaoka H, Yamaguchi A, Obokata M, Koitabashi N, Goto K, Hishiki T, Nagahata Y, Matsui H, Sano M, Kobayashi M, Kikuchi O, Sasaki T, Maeda K, Murakami M, Kitamura T, Suematsu M, Tsushima Y, Endo K, Hotamisligil GS, Kurabayashi M
    • Journal Title

      PLoS One

      Volume: 14;8 Issue: 11 Pages: e79386-e79386

    • DOI

      10.1371/journal.pone.0079386

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Capillary endothelial fatty acid binding proteins 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle2013

    • Author(s)
      Iso Tatsuya, Kurabayashi Masahiko
    • Journal Title

      Arteriosclerosi Thrombosis and Vascular Biology

      Volume: vol.33 Issue: 11 Pages: 2549-2557

    • DOI

      10.1161/atvbaha.113.301588

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 【今知りたい!集中治療の最新論点-Pro & Conディベート-】 栄養 栄養管理に中心静脈栄養法は不要である?2013

    • Author(s)
      巽 博臣, 今泉 均, 升田 好樹, 吉田 真一郎, 坂脇 英志, 後藤 京子, 高橋 科那子, 山蔭 道明, 大川 牧生, 国元 文生
    • Journal Title

      救急・集中治療

      Volume: 25 Pages: 1194-1200

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparative effects of flurbiprofen and fentanyl on natural killer cell cytotoxicity, lymphocyte subsets and cytokine concentrations in post-surgical intensive care unit patients: prospective, randomized study.2013

    • Author(s)
      Narahara H, Kadoi Y, Hinohara H, Kunimoto F, Saito S.
    • Journal Title

      Journal of Anesthesia

      Volume: 27 Issue: 5 Pages: 676-683

    • DOI

      10.1007/s00540-013-1597-5

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 乳癌の抗癌薬によるアナフィラキシー様反応により呼吸不全を生じ、ECMO使用により救命できた1例2013

    • Author(s)
      柳澤 晃広,金本 匡史,久保 和弘,日野原 宏, 国元 文生,齋藤 繁
    • Journal Title

      臨床麻酔

      Volume: 37

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Perioperative nutriture in esophageal cancer patients undergoing esophagectomy.2013

    • Author(s)
      Kobayashi T, Oshima K, Yokobori T, Idetsu A, Hayashi Y, Hinohara RN, Miyazaki T, Kunimoto F, Kato H, Kuwano H.
    • Journal Title

      Hepatogastroenterology

      Volume: 60 Pages: 1311-6

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] PPARgamma in Capillary Endothelia Promotes Fatty Acid Uptake by Heart During Long-term Fasting.2013

    • Author(s)
      Goto K, Iso T, Hanaoka H, Suga T, Hattori A, Irie Y, Shinagawa Y, Matsui H, Syamsunarno MRAA, Matsui M, Haque A, Arai M, Kunimoto F, Yokoyama T, Endo K, Gonzalez FJ, Kurabayashi M.
    • Journal Title

      J Am Heart Assoc.

      Volume: 2(1)

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 術後の血管系合併症-その診断と対策 術後の肺動脈塞栓 治療のコツ2013

    • Author(s)
      猪瀬崇徳,宮崎達也,鈴木茂正,田中成岳,国元文生,桑野博行
    • Journal Title

      臨床外科

      Volume: 68(2) Pages: 158-163

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Stearoyl-CoA Desaturase-1 (SCD1) Augments Saturated Fatty Acid-Induced Lipid Accumulation and Inhibits Apoptosis in Cardiac Myocytes.2012

    • Author(s)
      Matsui H, Yokoyama T, Sekiguchi K, Iijima D, Sunaga H, Maniwa M, Ueno M, Iso T, Arai M, Kurabayashi M.
    • Journal Title

      PLoS One.

      Volume: 7(3)

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Azelnidipine inhibits Msx2-dependent osteogenic differentiation and matrix mineralization of vascular smooth muscle cells.2012

    • Author(s)
      Shimizu T, Tanaka T, Iso T, Kawai-Kowase K, Kurabayashi M.
    • Journal Title

      Int Heart J.

      Volume: 53(5) Pages: 331-335

    • NAID

      130001914171

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Necrotizing fasciitis following psoas muscle abscess caused by hypermucoviscous Klebsiella pneumoniae.2012

    • Author(s)
      Mita N, Narahara H, Okawa M, Hinohara H, Kunimoto F, Haque A, Saito S, Oshima K.
    • Journal Title

      J Infect Chemother

      Volume: 18(4) Pages: 565-8

    • NAID

      10030948251

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] ICU患者における血清マグネシウムイオン値と重症度の関連2012

    • Author(s)
      楢原創,金本匡史,大川牧生,日野原宏,国元文生,齋藤繁
    • Journal Title

      ICUとCCU

      Volume: 36(6) Pages: 445-450

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Deletion of Fatty Acid Binding Protein-4 and -5 Exacerbate Cardiac Dysfunction Because of Insufficient ATP production during Pressure Overload in Mice.2014

    • Author(s)
      Syamsunarno MRAA, Iso T, Koitabashi N, Kurabayashi M.
    • Organizer
      第31回 国際心臓研究学会(ISHR)日本部会
    • Place of Presentation
      名古屋(ウィンクあいち)
    • Year and Date
      2014-11-28 – 2014-11-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Deletion of Fatty Acid Binding Protein-4 and -5 Exacerbate Cardiac Dysfunction Because of Insufficient ATP Production during Pressure Overload in Mice.2014

    • Author(s)
      Syamsunarno MRAA, Iso T, Koitabashi N, Kurabayashi M.
    • Organizer
      The 87th annual meeting of American Heart Association
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2014-11-14 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Deficiency of Fatty Acid Binding Protein-4 and -5 Impairs Intestinal Lipid Absorption.2014

    • Author(s)
      Syamsunarno MRAA, Iso T, Kurabayashi M.
    • Organizer
      The 87th annual meeting of American Heart Association
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2014-11-14 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Long Chain Fatty Acid Composition Modulated by Elovl6 Plays a Critical Role in Vascular Smooth Muscle Cell Proliferation and Neointimal Formation.2014

    • Author(s)
      Matsui H, Sunaga H, Anjo S, Syamsunarno MRAA, Iso T, Matsuzaka T, Shimano H, Yokoyama T, Kurabayashi M.
    • Organizer
      The 87th annual meeting of American Heart Association
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2014-11-14 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Early Increase in Serum Fatty Acid Binding Protein 4 Levels in Patients with Acute Myocardial Infarction: Lipolysis as a Novel Marker for Myocardial Ischemia.2014

    • Author(s)
      Sunaga H, Ohyama Y, Obokata M, Iso T, Kawaguchi T, Koitabashi N, Funada R, Takama N, Syamsunarno MRAA, Matsui H, Yokoyama T, Kurabayashi M.
    • Organizer
      The 87th annual meeting of American Heart Association
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2014-11-14 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 筋型毛細血管内皮細胞を介する心筋・骨格筋の脂肪酸代謝の制御機構と全身代謝への影響2014

    • Author(s)
      13.磯達也、Mas Rizky、倉林正彦
    • Organizer
      第35回 日本肥満学会
    • Place of Presentation
      宮崎(シーガイアコンベンションセンター)
    • Year and Date
      2014-10-24 – 2014-10-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 心血管イベント時のダイナミックな血中FABP4濃度変化のメカニズムの解明2014

    • Author(s)
      14.須永 浩章, 磯 達也, 河口智香, 小板橋紀通, 松井 弘樹, 横山 知行, 倉林 正彦
    • Organizer
      第46回 日本動脈硬化学会総会・学術集会
    • Place of Presentation
      東京(京王プラザホテル)
    • Year and Date
      2014-07-10 – 2014-07-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脂肪酸伸長酵素Elovl6は血管平滑筋細胞の脂肪酸組成を調節することで増殖に関与する2014

    • Author(s)
      15.須永 浩章, 松井 弘樹, 安生 早紀, 磯 達也, 松坂 賢, 島野 仁, 横山 知行, 倉林 正彦
    • Organizer
      第46回 日本動脈硬化学会総会・学術集会
    • Place of Presentation
      東京(京王プラザホテル)
    • Year and Date
      2014-07-10 – 2014-07-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Fatty Acid Binding Protein 4 is a target gene of Dll4-Notch1 pathway in Capillary Endothelial Cells in Heart.2014

    • Author(s)
      16.Tatsuya Iso, Tomoka Kawaguchi, Naoto Yajima, Hiroki Matsui, Tomoyuki Yokayama, Masahiko Kurabayashi.
    • Organizer
      第46回 日本動脈硬化学会総会・学術集会
    • Place of Presentation
      東京(京王プラザホテル)
    • Year and Date
      2014-07-10 – 2014-07-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Fatty acid binding protein 4 and 5 are involved in formation of abodominal aortic aneurysm created by CaCl2 in mice.2014

    • Author(s)
      17.Tatsuya Iso, Tomoaki Ishii, Hiroki Matsui, Tomoyuki Yokoyama, Masahiko Kurabayashi.
    • Organizer
      第46回 日本動脈硬化学会総会・学術集会
    • Place of Presentation
      東京(京王プラザホテル)
    • Year and Date
      2014-07-10 – 2014-07-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Differential expression of FABP4 and FABP5 isoforms in macrophages during the development of atherosclerosis.2014

    • Author(s)
      18.Tatsuya Iso, Aiko Enoura, Harumi Ogura, Hiroki Matsui, Tomoyuki Yokoyama, Masahiko Kurabayashi.
    • Organizer
      第46回 日本動脈硬化学会総会・学術集会
    • Place of Presentation
      東京(京王プラザホテル)
    • Year and Date
      2014-07-10 – 2014-07-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Fatty acid binding protein 4 and 5 play a crucial role in adaptive response to prolonged fasting and cold exposure in mice.2014

    • Author(s)
      Mas Rizky A.A Syamsunarno, Tatsuya Iso, Masahiko Kurabayashi.
    • Organizer
      The 18th International Vascular Biology Meeting
    • Place of Presentation
      Miyakomesse, Kyoto
    • Year and Date
      2014-04-14 – 2014-04-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effects of long chain fatty acid composition regulated by Elovl6 on the proliferation of vascular smooth muscle cells.2014

    • Author(s)
      Hiroki Matsui, Hiroaki Sunaga, Saki Anjo, Tatsuya Iso, Tomoyuki Yokoyama, Masahiko Kurabayashi.
    • Organizer
      The 18th International Vascular Biology Meeting
    • Place of Presentation
      Miyakomesse, Kyoto
    • Year and Date
      2014-04-14 – 2014-04-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Circulating FABP4 is released from adipocytes and capillary endothelial cells by sympathetic activation via β3 receptor during acute cardiovascular event.2014

    • Author(s)
      Hiroaki Sunaga, Tatsuya Iso, Tomoka Kawaguchi, Mas Rizky Syamsunarno, Hiroki Matsui, Yoshiaki Ohyama, Tomoyuki Yokoyama, Masahiko Kurabayashi.
    • Organizer
      The 18th International Vascular Biology Meeting
    • Place of Presentation
      Miyakomesse, Kyoto
    • Year and Date
      2014-04-14 – 2014-04-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Differential expression of FABP4 and FABP5 isoforms in macrophages during the development of atherosclerosis.2014

    • Author(s)
      Tatsuya Iso, Aiko Enoura, Harumi Ogura, Hiroki Matsui, Tomoyuki Yokoyama, Masahiko Kurabayashi.
    • Organizer
      The 18th International Vascular Biology Meeting
    • Place of Presentation
      Miyakomesse, Kyoto
    • Year and Date
      2014-04-14 – 2014-04-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Fatty acid binding protein 4 and 5 are involved in formation of abodominal aortic aneurysm created by CaCl2 in mice.2014

    • Author(s)
      Tatsuya Iso, Tomoaki Ishii, Hiroaki Sunaga, Mas Rizky A.A Syamsunarno, Hiroki Matsui, Norimichi Koitabashi, Tomoyuki Yokoyama, Masahiko Kurabayashi.
    • Organizer
      The 18th International Vascular Biology Meeting
    • Place of Presentation
      Miyakomesse, Kyoto
    • Year and Date
      2014-04-14 – 2014-04-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Fatty Acid Binding Protein 4 is a direct target gene of Dll4-Notch1 pathway in Capillary Endothelial Cells in Heart.2014

    • Author(s)
      Tatsuya Iso, Tomoka Kawaguchi, Naoto Yajima, Hiroki Matsui, Tomoyuki Yokayama, Masahiko Kurabayashi.
    • Organizer
      The 18th International Vascular Biology Meeting
    • Place of Presentation
      Miyakomesse, Kyoto
    • Year and Date
      2014-04-14 – 2014-04-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Glucose Uptake in the Heart of FABP4/5 double knockout mice is Promoted by Allosteric and Post-transcriptional Regulation of Glycolytic Pathways.2014

    • Author(s)
      Tatsuya Iso, Kazuhisa Maeda, Hirofumi Hanaoka, Kosaku Goto, Mas Rizky A.A Syamsunarno, Takako Hishiki, Yoshiko Nagahata, Hiroki Matsui, Masashi Arai, Aiko Yamaguchi, Motoaki Sano, Makoto Suematsu, Keigo Endo, Gökhan S. Hotamisligil and Masahiko Kurabayashi.
    • Organizer
      The 18th International Vascular Biology Meeting
    • Place of Presentation
      Miyakomesse, Kyoto
    • Year and Date
      2014-04-14 – 2014-04-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Fatty Acid Binding Protein 4 and -5 Play a Crucial Role in Theromogenesis under Cold Stress during Fasting.2014

    • Author(s)
      Mas R.A.A. Syamsunarno ,Iso T, Mirasari Putri , Yamaguchi A, Kurabayashi M.
    • Organizer
      第78回 日本循環器学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] ICU患者の急性期投与エネルギー量は20~25kcal/kgも必要ない2014

    • Author(s)
      国元文生
    • Organizer
      第41回日本集中治療医学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Oral Assesment Sheetを用いた口腔ケア回診での口腔スコアの経時的変化と課題2014

    • Author(s)
      福士宙之,神山治郎,柳澤晃広,河内奈穂美,楢原創,金本匡史,戸部賢,日野原宏,根岸明秀,国元文生
    • Organizer
      第41回日本集中治療医学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] Fatty acid binding protein 4 and 5 play a crucial role in adaptive response to prolonged fasting and cold exposure in mice.2013

    • Author(s)
      Syamsunarno MRAA, Tatsuya Iso, Masahiko Kurabayashi.
    • Organizer
      Annual meeting of American Heart Association
    • Place of Presentation
      Dallas, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] A protective role of Fibroblast growth factor 23 against vascular calcification.2013

    • Author(s)
      Nakahara T, Keiko Kawai-Kowase, Hiroki Matsui, Tatsuya Iso、Toshihiro Utsugi, Shoichi Tomono, Masashi Arai, Masahiko Kurabayashi.
    • Organizer
      Annual meeting of American Heart Association
    • Place of Presentation
      Dallas, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Association between serum FABP4 levels, pericardial adipose tissue volume, and plaque characteristics in patients with type 2 diabetes mellitus.2013

    • Author(s)
      Nakahara T, Keiko Kawai-Kowase,Rieko Nakahara,Toshihiro Utsugi, Tatsuya Iso, Masashi Arai, Shoichi Tomono, Yoshito Tsushima, Masami Murakami, Masahiko Kurabayashi.
    • Organizer
      Annual meeting of American Heart Association
    • Place of Presentation
      Dallas, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Capillary endothelial fatty acid binding protein 4 and 5 are required for sufficient energy production in the heart.2013

    • Author(s)
      Tatsuya Iso, Masahiko Kurabayashi.
    • Organizer
      European Society of Cardiology Congress
    • Place of Presentation
      Amsterdam, Netherlands
    • Related Report
      2013 Research-status Report
  • [Presentation] Evidence for a Protective Role of Fibroblast Growth Factor 23 against Vascular Calcification.2013

    • Author(s)
      Nakahara T, Kowase K, Matsui h, Iso T, Utsugi O, Tomono S, Ogawa A, Kanesawa N, Kurabayashi M.
    • Organizer
      第78回 日本循環器学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Serum FABP4 Levels are Associated with Pericardial Adipose Tissue Volume and Plaque Characteristics in Patients with Type 2 Diabetes Mellitus.2013

    • Author(s)
      Nakahara T, Kowase K, Nakahara R, Utsugi T, Iso T, Tomono S, Tsushima Y, Murakami M , Kurabayashi M.
    • Organizer
      第78回 日本循環器学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Differential Release Kinetic of Serum FABP3, FABP4 and FABP5 in the Patients with Acute Coronary Syndrome.2013

    • Author(s)
      Obokata M, Iso T, Ohyama Y, Murata M, Matsuo Y, Sano H, Funada R, Takama N, Koitabashi N, Nakajima T, Kaneko Y, Kurabayashi M.
    • Organizer
      第78回 日本循環器学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Fatty Acid Binding Protein-4 and -5 are Expressed in Intestinal Capillary Endothelial Cells and Regulate Lipid Absorption.2013

    • Author(s)
      Mas R.A.A. Syamsunarno , Iso T, Kurabayashi M.
    • Organizer
      第78回 日本循環器学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Effects of Long Chain Fatty Acid Composition Regulated by Elovl6 on the Proliferation of Vascular Smooth Muscle Cells.2013

    • Author(s)
      Anjo S, Matsui H, Sunaga H, Iso T, Kurabayashi M, Yokoyama T.
    • Organizer
      第78回 日本循環器学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Fatty Acid Binding Protein 4 and 5 Differentially Regulate Formation of Abdominal Aortic Aneurysm Induced by Calcium Chloride in Mice.2013

    • Author(s)
      Ishii T, Iso T, Sunaga H,2Mas Rizky Syamsunarno , Matsui H, Koitabashi N, Yokoyama T, Kurabayashi M.
    • Organizer
      第78回 日本循環器学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Fatty Acid Binding Protein 4 is a Direct Target Gene of Dll4-Notch1 Pathway in Capillary Endothelial Cells in Heart.2013

    • Author(s)
      Kawaguchi T, Iso T, Yajima N, Matsui H, Yokoyama T, Kurabayash M.
    • Organizer
      第78回 日本循環器学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Circulating FABP4 is Released from Adipocytes and Capillary Endothelial Cells by Sympathetic Activation via β3 Receptor during Acute Cardiovascular Event.2013

    • Author(s)
      Kawaguchi T, Iso T, Sunaga H, Mas Rizky A.A Syamsunarno, Matsui H, Ohyama Y, Yokoyama T, Kurabayashi M.
    • Organizer
      第78回 日本循環器学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Fatty acid binding protein 4 and 5 play a crucial role in adaptive response to prolonged fasting and cold exposure in mice.2013

    • Author(s)
      Mas Rizky A.A Syamsunarno, Tatsuya Iso, Masahiko Kurabayashi.
    • Organizer
      第17回 日本心血管内分泌代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] 筋型毛細血管内皮細胞に発現するFABP4/5は絶食時の全身の代謝適応に重要な役割を果たす2013

    • Author(s)
      磯 達也
    • Organizer
      第34回 日本肥満学会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Notchシグナルによる血管細胞の分化制御2013

    • Author(s)
      磯 達也
    • Organizer
      第21回 日本血管生物医学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] プロカルシトニン(PCT)値と各種細菌培養結果との検討2013

    • Author(s)
      柳澤晃広,福士宙之,神山治郎,楢原創,金本匡史,久保和宏,戸部賢,日野原宏,門井雄司,国元文生,齋藤繁
    • Organizer
      第22回日本集中治療医学会関東甲信越地方会
    • Place of Presentation
      筑波
    • Related Report
      2013 Research-status Report
  • [Presentation] Capillary endothelial Fatty Acid Binding Protein 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle.2013

    • Author(s)
      Tatsuya Iso
    • Organizer
      第90回 日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Glucose Uptake in the Heart of FABP4/5 Double Knockout Mice is Promoted by Allosteric and Post-transcriptional Regulation of Glycolytic Pathways2013

    • Author(s)
      Tatsuya Iso, Hiroki Matsui, Motoaki Sano, Takako Hishiki, Yoshiko Nagahata, Makoto Suematsu, Masahiko Kurabayashi
    • Organizer
      第77回 日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] Defective Fatty Acid Uptake through Capillary Endothelial Cells of Heart and Skeletal Muscle Induces Prominent Fatty Liver2013

    • Author(s)
      Mas Rizky A.A Syamsunarno, Tatsuya Iso, Masahiko Kurabayashi
    • Organizer
      第77回 日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] Detrimental effects of FABP4 and FABP5 Deletion on Hepatic Energy Metabolism after Prolonged Fasting2013

    • Author(s)
      Mas Rizky A.A Syamsunarno, Tatsuya Iso, Masahiko Kurabayashi
    • Organizer
      第77回 日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] Differential Expression of FABP4 and FABP5 Isoforms in Macrophages during the Development of Atherosclerosis2013

    • Author(s)
      Aiko Enoura,Tatsuya Iso, Harumi Ogura, Hiroki Matsui, Tomoyuki Yokoyama, Masahiko Kurabayashi
    • Organizer
      第77回 日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] GPIHBP1, an Endothelial Binding Site for Lipoprotein Lipase and Chylomicrons, is Induced by Peroxisome proliferator-activated receptor- ϒ in Cardiac Fibroblasts2013

    • Author(s)
      Hiroaki Takahashi., Tatsuya Iso, Hiroki Matsui, Tomoyuki Yokoyama, Masahiko Kurabayashi
    • Organizer
      第77回 日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] Circulating Fatty Acid Binding Protein 4 is an early marker for Acute Myocardial Infarction2013

    • Author(s)
      Yoshiaki Ohyama, Tatsuya Iso, Kuniko Masuda, Shuntaro Tamura, Makoto Murata, Kosaku Goto, Ryuichi Funada, Norimichi Koitabashi, Noriaki Takama, Masahi Arai, Masahiko Kurabayashi
    • Organizer
      第77回 日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] Differential Time-dependent Changes in Fatty Acid Binding Protein Isoforms Levels in Patients with Acute Myocardial Infarction and Acute Heart Failure2013

    • Author(s)
      Yoshiaki Ohyama, Tatsuya Iso, Kuniko Masuda, Shuntaro Tamura, Makoto Murata, Kosaku Goto, Ryuichi Funada, Norimichi Koitabashi, Noriaki Takama, Masahi Arai, Masahiko Kurabayashi
    • Organizer
      第77回 日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] Fibroblast growth factor 23 inhibits osteogenic differentiation of vascular smooth muscle cells: A protective role against vascular calcification.2013

    • Author(s)
      Takehiro Nakahara, Keiko Kawai-Kowase, Hiroki Matsui, Tatsuya Iso, Toshihiro Utsugi, Shoichi Tomono,Ogawa A., Norio Kanesawa, Masashi Arai, Kurabayashi M.
    • Organizer
      第77回 日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] Quantification of Cardiac Energetic Substrates in the Development of Heart Failure Induced by Pressure-overload in Mice2013

    • Author(s)
      Norimichi Koitabashi, Masaru Obokata, Aiko Yamaguchi, Mas Rizky A.A Syamsunarno, Kosaku Goto, Tatsuya Iso, Masashi Arai, Hirofumi Hanaoka, Yoshito Tsushima, Masahiko Kurabayashi
    • Organizer
      第77回 日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 塩酸ピルジカイニド中毒により心室頻拍を呈した1例2013

    • Author(s)
      村田将人,萩原周一,金子稔,青木誠,古川和美,中村卓郎,大山良雄,田村遵一,国元文生,大嶋清宏
    • Organizer
      第40回 日本集中治療医学会学術集会
    • Place of Presentation
      松本
    • Related Report
      2012 Research-status Report
  • [Presentation] L-FABPによる腎機能低下の早期診断における有用性2013

    • Author(s)
      柳澤晃広,楢原創,金本匡史,大川牧生,戸部賢,高澤知規,日野原宏,門井雄司,国元文生,齋藤繁
    • Organizer
      第40回 日本集中治療医学会学術集会
    • Place of Presentation
      松本
    • Related Report
      2012 Research-status Report
  • [Presentation] 重症患者栄養管理のエビデンスとプラクティス2013

    • Author(s)
      国元文生
    • Organizer
      第40回 日本集中治療医学会学術集会
    • Place of Presentation
      松本
    • Related Report
      2012 Research-status Report
  • [Presentation] Fatty Acid Binding Protein 4 and Fatty Acid Translocase are Induced by Notch Signaling via Induction of PPARγ in Capillary Endothelial Cells in Heart After Long Time Fasting2012

    • Author(s)
      Tatsuya Iso, Naoto Yajima, Tomoka Kawaguchi, Kyosuke Takeshita, Hiroki Matsui, Kosaku Goto, Tomoyuki Yokoyama, Masahiko Kurabayashi.
    • Organizer
      Annual meeting of American Heart Association
    • Place of Presentation
      Los Angeles, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Long-Chain Fatty Acid Elongase, Elovl6, is Crucial for Vascular Smooth Muscle Cell Proliferation Underlying Neointimal Hyperplasia2012

    • Author(s)
      Hiroaki Sunaga, Hiroki Matsui, Tomoyuki Yokoyama, Saki Anjo, Tatsuya Iso, Masahiko Kurabayashi
    • Organizer
      Annual meeting of American Heart Association
    • Place of Presentation
      Los Angeles, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Fibroblast Growth Factor 23 Inhibits Osteogenic Differentiation of Vascular Smooth Muscle Cells: A Protective Role Against Vascular Calcification.2012

    • Author(s)
      Takehiro Nakahara, Keiko Kawai-Kowase, Hiroki Matsui, Tatsuya Iso, Toshihiro Utsugi, Shoichi Tomono, Masashi Arai, Masahiko Kurabayashi
    • Organizer
      Annual meeting of American Heart Association
    • Place of Presentation
      Los Angeles, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Glucose uptake in the heart of mice doubly deficient for FABP4/5 is dramatically promoted by allosteric and post-transcriptional regulation independently of insulin2012

    • Author(s)
      Tatsuya Iso, Kazuhisa Maeda, Hirofumi Hanaoka, Mas Rizky, Takako Hishiki, Hiroki Matsui, Aiko Yamaguchi, Makoto Suematsu, Gokhan S. Hotamisligil, Masahiko Kurabayashi
    • Organizer
      第29回国際心臓研究学会(ISHR)日本部会総会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] FABP4 and FAT/CD36 are induced by Notch Signaling via Induction of PPARgamma in Capillary Endothelial Cells in Heart after long time fasting2012

    • Author(s)
      Tatsuya Iso, Naoto Yajima, Kyosuke Takeshita, Hiroki Matsui, Kosaku Goto, Tomoyuki Yokayama, Masahiko Kurabayashi
    • Organizer
      第29回国際心臓研究学会(ISHR)日本部会総会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] PPARgamma in Capillary Endothelia Promotes Fatty Acid Uptake by Heart During Long-term Fasting2012

    • Author(s)
      Kosaku Goto, Tatsuya Iso, Hirofumi Hanaoka, Frank Gonzalez, Masahiko Kurabayashi
    • Organizer
      第29回国際心臓研究学会(ISHR)日本部会総会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Book] 血管新生研究の最先端 「Notchシグナル」2013

    • Author(s)
      磯 達也
    • Total Pages
      7
    • Publisher
      医薬ジャーナル社
    • Related Report
      2012 Research-status Report
  • [Remarks] 群馬大学大学院医学系研究科 臓器病態内科学 循環器内科 基礎研究 磯グループ

    • URL

      http://gunma-u-med2.jp/%E5%8C%BB%E7%99%82%E3%82%B0%E3%83%AB%E3%83%BC%E3%83%97/%E5%8C%BB%E7%99%82%E3%82%B0%E3%83%AB%E3%83%BC%E3%83%97-%E5%BE%AA%E7%92%B0%E5%99%A8%E5%86%85%E7%A7%91/

    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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