Development of a novel trauma mortality prediction score from Japan

• Project/Area Number: 24592731
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Kameda College of Health Sciences (2016-2017); Tokyo Medical and Dental University (2012-2015)
• Principal Investigator: Shiraishi Atsushi 亀田医療大学, 総合研究所, 客員研究員 (40401343)
• Co-Investigator(Kenkyū-buntansha): 大友 康裕 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (40176946)
• Project Period (FY): 2012-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 転帰予測研究 / 外傷初期診療 / トリアージ / データベース研究 / 外傷重症度スコア / 生理学的指標 / 多施設共同研究 / 観察研究 / 診断精度 / 外傷 / 外傷疫学 / 予測モデル / コホート研究 / 国際研究者交流 / イギリス / フランス / アメリカ合衆国

Outline of Final Research Achievements

A physiological trauma severity score to predict in-hospital mortality which could be easily calculated from age and physiological variables on arrival at the emergency department (consciousness, respiratory rate and blood pressure) was developed from a part of adult (>15 year old) trauma patients registered in the Japan Trauma Databank (JTDB). In comparison with conventional scores using an another part of patients registered in JTDB (internal validation) and trauma patients participated in the randomized controlled trial in overseas, this novel score demonstrated improved prognostic ability in terms of receiver operating characteristics (ROC) analysis, partial ROC analysis with restricted sensitivity of > 0.9 and net reclassification improvement analysis.

Research Products

• [Journal Article] Assessment of Progress in Early Trauma Care in Japan over the Past Decade: Achievements and Areas for Future Improvement (2017)
  • Author(s): Endo Akira、Shiraishi Atsushi、Matsui Hiroki、Hondo Kenichi、Otomo Yasuhiro
  • Journal Title: Journal of the American College of Surgeons Volume: 224 Issue: 2 Pages: 191-198e5
  • DOI: 10.1016/j.jamcollsurg.2016.10.051
  • Peer Reviewed
• [Journal Article] Open-chest versus closed-chest cardiopulmonary resuscitation in blunt trauma: analysis of a nationwide trauma registry (2017)
  • Author(s): Endo Akira、Shiraishi Atsushi、Otomo Yasuhiro、Tomita Makoto、Matsui Hiroki、Murata Kiyoshi
  • Journal Title: Critical Care Volume: 21 Issue: 1 Pages: 1-1
  • DOI: 10.1186/s13054-017-1759-1
  • Peer Reviewed / Open Access
• [Journal Article] Effectiveness of early administration of tranexamic acid in patients with severe trauma. (2017)
  • Author(s): Shiraishi A, Kushimoto S, Otomo Y, Matsui H, Hagiwara A, Murata K; Japanese Observational Study for Coagulation and Thrombolysis in Early Trauma (J-OCTET) investigators.
  • Journal Title: British Journal of Surgery Volume: 104 Issue: 6 Pages: 710-717
  • DOI: 10.1002/bjs.10497
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Development of Novel Criteria of the "Lethal Triad" as an Indicator of Decision Making in Current Trauma Care: A Retrospective Multicenter Observational Study in Japan. (2016)
  • Author(s): Endo A, Shiraishi A, Otomo Y, Kushimoto S, Saitoh D, Hayakawa M, Ogura H, Murata K, Hagiwara A, Sasaki J, Matsuoka T, Uejima T, Morimura N, Ishikura H, Takeda M, Kaneko N, Kato H, Kudo D, Kanemura T, Shibusawa T, Hagiwara Y, Furugori S, Nakamura Y, Maekawa K, Mayama G, Yaguchi A, Kim S, Takasu O, Nishiyama K.
  • Journal Title: Critical Care Medicine Volume: 4 Issue: 9 Pages: 797-803
  • DOI: 10.1097/ccm.0000000000001731
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Derivation and External Validation of a Novel Prediction Score for Early Trauma Care (2015)
  • Author(s): Atsushi Shiraishi
  • Organizer: 19th World Congress of Disaster and Emergency Medicine
  • Place of Presentation: Cape Town, South Africa
  • Year and Date: 2015-04-21 – 2015-04-24
• [Presentation] Derivation and External Validation of a Novel Prediction Score for Early Trauma Care (2015)
  • Author(s): Shiraishi A, Roberts I, Otomo Y
  • Organizer: World Congress of Disaster and Emergency Medicine
  • Place of Presentation: Cape Town, South Africa
  • Year and Date: 2015-04-21
  • Int'l Joint Research
• [Presentation] External Validation of A Novel Trauma Score on CRASH-2 cohort (2014)
  • Author(s): Atsushi Shiraishi
  • Organizer: 14th European Congress of Trauma and Emergency Surgery
  • Place of Presentation: Lyon, France
• [Presentation] 新しい外傷重症度スコア, TRIAGES score –CRASH-2コホートでの外部検証 (2012)
  • Author(s): 白石 淳、齋藤大蔵、Ian Roberts、大友康裕
  • Organizer: 第40回日本救急医学会総会・学術集会
  • Place of Presentation: 京都