Exploratory research for the better outcome of septic encephalopathy
| Project/Area Number |
24592734
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Institute of Physical and Chemical Research (2015-2016)
Kyoto University (2012-2014) |
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Principal Investigator |
Imamura Yukio 国立研究開発法人理化学研究所, 生命システム研究センター, 研究員 (90447954)
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| Co-Investigator(Kenkyū-buntansha) |
松本 直也 大阪大学, 医学系研究科, 招へい教員 (50359808)
精山 明敏 京都大学, 医学研究科, 教授 (70206605)
神 隆 国立研究開発法人理化学研究所, 生命システム研究センター, チームリーダー (80206367)
三谷 智子 岐阜医療科学大学, 保健科学部, 教授 (30378757)
村上 由希 同志社大学, 研究開発推進機構, 助教 (50580106)
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| Research Collaborator |
YOSHIKAWA nao 京都大学, 医学研究科・人間健康科学専攻, 大学院生
WANG huan 京都大学, 医学研究科・分子医学系専攻, 大学院生
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| Project Period (FY) |
2012-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2014: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2013: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2012: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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| Keywords | 敗血症性脳症 / 量子ドット / イメージング / 分子機構 / 蛍光プローブ / 脳機能 / 感染症 / 敗血症 / 機能障害 / 治療介入 / 近赤外 / 脳症 / 電気生理 / 近赤外イメージング / NMDA型グルタミン酸受容体 / 感覚神経障害 / 体性感覚 / マウス脳 / 生化学的解析 / 行動学的解析 / 細胞外マトリックス分解酵素 / 電気生理学的解析 / 生化学的解析法 |
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| Outline of Final Research Achievements |
In this study, we examined molecular mechanisms and challenged to find a novel way of medical intervention for septic encephalopathy. To tackle these issues, we conducted the following experiments: 1) establishment and evaluation of mouse model for septic encephalopathy, 2) possible involvement of glutamatergic synaptic receptor and interleukin-1 receptor for the molecular mechanisms, 3) tested whether activation of anti-inflammatory pathways improved septic encephalopathy. Our findings suggest that histone acetylation mediated regulation of ionotropic and interleukin receptors for the better outcome of septic encephalopathy. In addition, activation of anti-inflammatory pathway may be beneficial for the better prognosis of septic encephalopathy
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Report
(6 results)
Research Products
(39 results)
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[Journal Article] Effect of Histone Acetylation on N-Methyl-D-Aspartate 2B Receptor Subunits and Interleukin-1 Receptors in Association with Nociception-Related Somatosensory Cortex Dysfunction in A Mouse Model of Sepsis2016
Author(s)
Yukio Imamura, Nao Yoshikawa, Yuki Murkami, Satoko Mitani, Naoya Matsumoto,Hisatake Matsumoto, Tomoki Yamada, Kazuma Yamakawa, Junichiro Nakagawa, Hiroshi Ogura, Takeshi Shimazu, Takashi Jin
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Journal Title
Shock
Volume: 45(6)
Issue: 6
Pages: 660-667
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1.2016
Author(s)
Murakami Y, Ishibashi T, Tomita E, Imamura Y, Tashiro T, Watcharanurak K, Nishikawa M, Takahashi Y, Takakura Y, Mitani S, Fujigaki H, Ohta Y, Kubo H, Mamiya T, Nabeshima T, Kim HC, Yamamoto Y, Saito K.
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Journal Title
SCIENTIFIC REPORTS
Volume: 6
Issue: 1
Pages: 29920-29920
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] The Beneficial Effects of ETS- GS, a Novel Vitamin E Derivative, on a Rat Model of Crush Injury2016
Author(s)
Nakagawa, Junichiro; Matsumoto, Naoya; Nakane, Yuko; Yamakawa, Kazuma; Yamada, Tomoki; Matsumoto, Hisatake; Shimazaki, Junya; Imamura, Yukio; Ogura, Hiroshi; Jin, Takashi; Shimazu, Takeshi
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Journal Title
Shock
Volume: 7
Issue: 6
Pages: 681-687
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Continual dynamics of prefrontal oxyhemoglobin patterns during emotion and feeling in humans.2015
Author(s)
Yukio Imamura*, Shota Hori, Natsuki Tsujita, Nao Yoshikawa, Yuki Murakami, Satoko Mitani, Wang Huan, Keijiro Yamada, Takashi Jin, Shoken Koh, Akitoshi Seiyama:
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Journal Title
Journal of Multidisciplinary Engineering Science Studies
Volume: 1
Pages: 6-11
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Book] In vivo imaging of septic encephalopathy2017
Author(s)
Yukio Imamura, Yuki Murakami, Naoya Matsumoto, Hisatake Matsumoto, Satoko Mitani, Kentaro Shimizu, Hiroshi Ogura, Takeshi shimazu, Takashi Jin
Total Pages
21
Publisher
In-tech open access publisher
Related Report
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[Book] Encephalopathies: Symptoms, Causes and Potential Complications, Chapter title: Septic encephalopathy2013
Author(s)
Yukio Imamura, Shota Hori, Naoya Matsumoto, Kazuma Yamakawa, Junichiro Nakagawa, Junya Shimazaki, Huan Wang, Junji Itou, Yuki Murakami, Satoko Mitani, Hiroshi Ogura, Takeshi Shimazu, Akitoshi Seiyama,
Total Pages
186
Publisher
Nova Publisher
Related Report
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