Challenge to development of a new blood purification membrane in continuous hemodiafiltration

• Project/Area Number: 24592740
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Oita University
• Principal Investigator: YASUDA Norihisa 大分大学, 医学部, 助教 (90537101)
• Co-Investigator(Kenkyū-buntansha): 後藤 孝治 大分大学, 医学部, 講師 (10363558)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 急性血液浄化療法 / 血液浄化膜 / ビタミンE / 急性血液ろ過 / 集中治療 / 急性炎症 / 臓器障害 / ろ過膜 / 新規血液浄化カラム / ビタミンE誘導体 / リポイルビタミンE

Outline of Final Research Achievements

In this study, we proved that capacity to control acute inflammation response is different in various dialyzers and that vitamin E-coated dialyzer and Ethylene-co-vinyl-alcohol (EVAL） membrane dialyzer could improve survival. Therefore, coating substances that have anti-inflammatory and anti-oxidation effects on the surface of membrane could lead to development of a new treatment method.
However, There are a lot of problems to be elucidated and we will continue our study in order to develop a new blood purification membrane more effective in continuous hemodiafiltration.