| Project/Area Number |
24592746
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Emergency medicine
|
|---|
| Research Institution | Iwate Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
BEPPU Takaaki 岩手医科大学, 医学部, 教授 (70275543)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OGASAWARA Kuniaki 岩手医科大学, 医学部, 教授 (00305989)
|
|---|
| Research Collaborator |
LE BIHAN Denis フランス原子力庁超高磁場, MRI 研究センターNeurospin
LUISA Ciobanu フランス原子力庁超高磁場, MRI 研究センターNeurospin
DJEMAI Boucif フランス原子力庁超高磁場, MRI 研究センターNeurospin
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
|
|---|
| Keywords | 医学 / 脳科学 / 脳計測科学 / MRI / 画像解析 / 統計学 / 放射線科学 / 一酸化炭素中毒 / 脳温 / MRS / 拡散強調像 / 拡散テンソル解析 / 拡散テンソル / 脳循環代謝 / 拡散強調 |
|---|
| Outline of Final Research Achievements |
In this study, 1H-magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) were performed at 3-Tesla Magnetic Resonance Imaging system for estimating brain temperature (BT) and the extent of white matter damage in carbon monoxide (CO) poisoned patients and healthy control subjects.
Finally, we got the following results: 1.BT of CO-poisoned patient was significantly higher in the acute phase than that of the control. In the subacute phase, BT was significantly lower than that in the acute phase but was kept higher than the controls. 2.BT in the subacute CO-poisoned patient correlated with the extent of white matter damage. 3.New DTI-based BT was significantly correlated with MRS-based BT which can accurately estimate BT. Consequently, this results suggest that we achieved the purpose to non-invasively measure brain perfusion and metabolism and to predict development of symptom in a part of the patients although it needs more number of subjects to exactly validate.
|
