Development of non-invasive method to quantitatively measure brain perfusion and metabolism in carbon monoxide poisoning

• Project/Area Number: 24592746
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Iwate Medical University
• Principal Investigator: FUJIWARA Shunro 岩手医科大学, 医学部, 助教 (60405842)
• Co-Investigator(Kenkyū-buntansha): BEPPU Takaaki 岩手医科大学, 医学部, 教授 (70275543)
• Co-Investigator(Renkei-kenkyūsha): OGASAWARA Kuniaki 岩手医科大学, 医学部, 教授 (00305989)
• Research Collaborator: LE BIHAN Denis フランス原子力庁超高磁場, MRI 研究センターNeurospin ; LUISA Ciobanu フランス原子力庁超高磁場, MRI 研究センターNeurospin ; DJEMAI Boucif フランス原子力庁超高磁場, MRI 研究センターNeurospin
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 医学 / 脳科学 / 脳計測科学 / MRI / 画像解析 / 統計学 / 放射線科学 / 一酸化炭素中毒 / 脳温 / MRS / 拡散強調像 / 拡散テンソル解析 / 拡散テンソル / 脳循環代謝 / 拡散強調

Outline of Final Research Achievements

In this study, 1H-magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) were performed at 3-Tesla Magnetic Resonance Imaging system for estimating brain temperature (BT) and the extent of white matter damage in carbon monoxide (CO) poisoned patients and healthy control subjects.
Finally, we got the following results: 1.BT of CO-poisoned patient was significantly higher in the acute phase than that of the control. In the subacute phase, BT was significantly lower than that in the acute phase but was kept higher than the controls. 2.BT in the subacute CO-poisoned patient correlated with the extent of white matter damage. 3.New DTI-based BT was significantly correlated with MRS-based BT which can accurately estimate BT. Consequently, this results suggest that we achieved the purpose to non-invasively measure brain perfusion and metabolism and to predict development of symptom in a part of the patients although it needs more number of subjects to exactly validate.

Research Products

• [Journal Article] Quantification of iron in the non-human primate brain with diffusion-weighted magnetic resonance imaging (2014)
  • Author(s): Fujiwara S, Uhrig L, Amadon A, Jarraya B, Le Bihan D
  • Journal Title: NeuroImage Volume: 102P2 Pages: 789-797
  • DOI: 10.1016/j.neuroimage.2014.08.049
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of the fitting process in diffusion MRI analysis using digital phantom of the human brain (2014)
  • Author(s): Fujiwara S, Le Bihan D, Ogawa A, Ogasawara K
  • Journal Title: Proceeding of World Automation Congress Volume: 1 Pages: 361-366
  • DOI: 10.1109/wac.2014.6935942
  • Peer Reviewed
• [Journal Article] Feasibility of diffusion MRI for quantifying the iron deposition in the non-human primate brain (2014)
  • Author(s): Fujiwara S, Uhrig L, Amadon A, Jarraya B, Le Bihan D
  • Journal Title: International Journal of Computer Assisted Radiology and Surgery Volume: 9
  • Peer Reviewed
• [Journal Article] Standardized uptake value in high uptake area on positron emission tomography with 18F-FRP170 as a hypoxic cell tracer correlates with intratumoral oxygen pressure in glioblastoma (2014)
  • Author(s): Beppu T, Terasaki K, Sasaki T, Fujiwara S, Matsuura H, Ogasawara K, Sera K, Yamada N, Uesugi N, Sugai T, Kudo K, Sasaki M, Ehara S, Iwata R, Takai Y
  • Journal Title: Mol Imaging Biol Volume: 16 Issue: 1 Pages: 127-135
  • DOI: 10.1007/s11307-013-0670-7
  • Peer Reviewed
• [Journal Article] Detection of misery perfusion in the cerebral hemisphere with chronic unilateral major cerebral artery steno-occlusive disease using crossed cerebellar hypoperfusion: comparison of brain SPECT and PET imaging. (2013)
  • Author(s): Matsumoto Y, Ogasawara K, Saito H, Terasaki K, Takahashi Y, Ogasawara Y, Kobayashi M, Yoshida K, Beppu T, Kubo Y, Fujiwara S, Tsushima E, Ogawa A
  • Journal Title: Eur J Nucl Med Mol Imaging. Volume: 40(10) Issue: 10 Pages: 1573-81
  • DOI: 10.1007/s00259-013-2463-2
  • Peer Reviewed
• [Journal Article] Diffusion Anisotropy Color-Coded Map of Cerebral White Matter: Quantitative Comparison between Orthogonal Anisotropic Diffusion-Weighted Imaging and Diffusion Tensor Imaging (2013)
  • Author(s): Uwano I, Sasaki M, Kudo K, Fujiwara S, Yamaguchi M, Saito A, Ogasawara K, Ogawa A.
  • Journal Title: J Neuroimaging Volume: 23 Issue: 2 Pages: 197-201
  • DOI: 10.1111/j.1552-6569.2011.00702.x
  • Peer Reviewed
• [Journal Article] Postoperative cerebral white matter damage associated with cerebral hyperperfusion and cognitive impairment after carotid endarterectomy: a diffusion tensor magnetic resonance imaging study. (2012)
  • Author(s): Nanba T, Ogasawara K, Nishimoto H, Fujiwara S, Kuroda H, Sasaki M, Kudo K, Suzuki T, Kobayashi M, Yoshida K, Ogawa A.
  • Journal Title: Cerebrovasc Dis. Volume: 34 Issue: 5-6 Pages: 358-367
  • DOI: 10.1159/000343505
  • Peer Reviewed
• [Journal Article] Preoperative 123I-iomazenil SPECT imaging predicts cerebral hyperperfusion following endarterectomy for unilateral cervical internal carotid artery stenosis. (2012)
  • Author(s): Ogasawara Y, Ogasawara K, Suzuki T, Yamashita T, Kuroda H, Chida K, Fujiwara S, Aso K, Kobayashi M, Yoshida K, Terasaki K, Ogawa A.
  • Journal Title: Am J Nucl Med Mol Imaging Volume: 2 Pages: 77-87
  • Peer Reviewed
• [Presentation] 拡散強調像に基づく大脳基底核鉄イメージングの開発 (2014)
  • Author(s): 藤原 俊朗、Lynn Uhrig、Alexis Amadon、Béchir Jarraya、Denis Le Bihan
  • Organizer: 日本脳神経外科学会第73回学術総会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-09 – 2014-10-11
• [Presentation] 拡散強調像デジタルファントム（DWI-DP）を用いた拡散係数推定モデルの精度検証 (2014)
  • Author(s): 藤原 俊朗、Denis Le Bihan、小川 彰、小笠原 邦昭
  • Organizer: 第42回日本磁気共鳴医学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-09-18 – 2014-09-20
• [Presentation] 拡散強調像に基づく新たな鉄イメージング手法の開発 (2014)
  • Author(s): 3.藤原 俊朗、Lynn Uhrig、Alexis Amadon、Béchir Jarraya、Denis Le Bihan
  • Organizer: 第42回日本磁気共鳴医学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-09-18 – 2014-09-20
• [Presentation] Evaluation of the fitting process in diffusion MRI analysis using digital phantom of the human brain (2014)
  • Author(s): Fujiawra S, Le Bihan D, Ogawa A, Ogasawara K
  • Organizer: World Automation Congress sponsored by IEEE
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2014-08-03 – 2014-08-08
• [Presentation] Feasibility of diffusion MRI for quantifying the iron deposition in the non-human primate brain (2014)
  • Author(s): Fujiwara S, Uhrig L, Amadon A, Jarraya B, Le Bihan D
  • Organizer: 28th International Congress and Exhibition of Computer Assisted Radiology and Surgery
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2014-06-25 – 2014-06-28
• [Presentation] 臨床応用に向けたDWI解析ソフトウェアの開発 (2014)
  • Author(s): 藤原 俊朗、Boucif Djemai、Luisa Ciobanu、Denis Le Bihan
  • Organizer: 第23回脳神経外科手術と機器学会
  • Place of Presentation: 福岡
  • Year and Date: 2014-04-18 – 2014-04-19
• [Presentation] 臨床応用に向けたDWI解析ソフトウェアの開発 (2014)
  • Author(s): 藤原俊朗、Boucif Djemai、Luisa Ciobanu、Denis Le Bihan
  • Organizer: 第23回脳神経外科と機器学会（CNTT)
  • Place of Presentation: 福岡
• [Presentation] 拡散テンソル画像を用いた全脳画像統計解析による一酸化炭素中毒亜急性期白質障害部位の特定 (2012)
  • Author(s): 藤原俊朗
  • Organizer: 第14回日本ヒト脳機能マッピング学会
  • Place of Presentation: 京王プラザホテル札幌
• [Book] これでわかる拡散MRI 第3版（全487ページ） (2013)
  • Author(s): 青木茂樹、阿部修、増谷佳孝、高原太郎 編著
  • Total Pages: 2
  • Publisher: 秀潤社