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Development of new equipment for intra-arrest brain cooling that uses cooled oxygen in the lungs: volunteer study

Research Project

Project/Area Number 24592751
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Emergency medicine
Research InstitutionNihon University

Principal Investigator

SAKURAI Atsushi  日本大学, 医学部, 准教授 (40339320)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Keywords蘇生 / 低体温療法 / 心停止 / 脳保護 / 肺冷却 / ボランティア研究 / 心肺蘇生 / 選択的脳低温療法 / 虚血中低体温 / cardiac arrest / hypothermia / brain protection
Outline of Final Research Achievements

Blood flow at the lungs must be very slow during CPR and the blood could be cooled by ventilating with cooled oxygen and the brain might then be cooled by the cooled blood. The aim of this study is to develop equipment to cool oxygen for this purpose and to confirm the safety of this equipment using volunteers. We developed new equipment to cool oxygen using a vinyl chloride coil submerged in a bottle of water and cooled in a refrigerator at -80 degree centigrade. Using this equipment, seven volunteers were administered oxygen by mask, and vital signs were measured. The temperature in the mask was also measured. This equipment was able to decrease the temperature in the mask with oxygen (10 L/min) to -5 degree centigrade. In the volunteer stud vital signs were unchanged. No adverse effects were observed in the volunteers after experimentation. We were able to develop new equipment to cool oxygen and the safety of this equipment was established by a volunteer study.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2014

All Presentation (2 results)

  • [Presentation] 心停止中の脳冷却のための酸素冷却装置の開発と効果、安全性の検討2014

    • Author(s)
      櫻井淳
    • Organizer
      日本蘇生学会第33回大会
    • Place of Presentation
      アクトシティー浜松コングレスセンター(静岡県浜松市)
    • Year and Date
      2014-12-05 – 2014-12-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 酸素冷却装置の開発-心停止中の脳冷却のために-2014

    • Author(s)
      櫻井淳
    • Organizer
      第42回日本救急医学会
    • Place of Presentation
      アクトシティー浜松コングレスセンター(静岡県浜松市)
    • Year and Date
      2014-10-28 – 2014-10-30
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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