A clarify of a mechanism of remote organ failure after tissue injury

• Project/Area Number: 24592753
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Nippon Medical School
• Principal Investigator: TSUKAMOTO Takeshi 日本医科大学, 医学部, 助教 (20626270)
• Co-Investigator(Kenkyū-buntansha): 増野 智彦 日本医科大学, 医学部, 講師 (00318528) ; 大泉 旭 日本医科大学, 医学部, 助教 (20277502) ; 横田 裕行 日本医科大学, 医学(系)研究科(研究院), 教授 (60182698)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 外傷 / 軟部組織損傷 / 遠隔臓器障害 / 骨軟部組織損傷 / 多臓器不全 / 臓器傷害

Outline of Final Research Achievements

To clarify the mechanism of remote organ failure after traumatic injury, we developed a new tissue trauma model (TBX model) and investigated the validity of this model.
TBX induced a systematic inflammatory response and attenuated a intestinal motility at 21 hours after transplantation of TBX.