| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
We investigated the impact of sepsis on the adaptive immune system and to monitor T cell receptor (TCR) diversity. TCR diversity was markedly decreased in septic patients at day 1 compared to the healthy volunteer. A recovery of TCR diversity was observed at days 3 and 7 except for dead patient. HLA-DR expression was significantly decreased in septic patients at day 1. Total lymphocyte count reduced in septic patients at day 1, but lymphocyte count recovered at days 3 and 7 except for dead patient. We observed a lower TCR diversity and lymphopenia in early stage of septic shock. A quickly recovery of TCR diversity and lymphocyte count were observed in live patients. On the other hand, dead patient stayed on the lower level over the course of the study. These results suggest that altered TCR diversity and lymphopenia might participate in increased mortality and susceptibility to secondary nosocomial infections.
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