Significance of procalcitonin in sepsis-analysis of procalcitonin knockout mouse-

• Project/Area Number: 24592757
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Osaka Kawasaki Rehabilitation University
• Principal Investigator: NAKAMURA Misa 大阪河崎リハビリテーション大学, 公私立大学の部局等, 教授 (70285386)
• Co-Investigator(Renkei-kenkyūsha): KONO Ryohei 和歌山県立医科大学, 医学部, 助教 (70569110)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: プロカルシトニン / 敗血症 / サイトカイン / ノックアウトマウス / カルシトニン

Outline of Final Research Achievements

The role of procalcitonin (PCT) in sepsis was investigated using PCT knockout mouse (PCT KO). However, there was no statistical difference of duration of survival between KO and wild injected of lipopolysaccharide (LPS), wild group showed a little higher survival rate than KO. And KO showed higher level of IL-6 and lower of IL-10 concentration in blood than wild. These results suggested that PCT have no effect on survival in sepsis, however reduces a condition of sepsis mediated by various cytokines.

Research Products

• [Journal Article] Up-regulation of urinary-type plasminogen activator correlates with high-risk papillary thyroid carcinoma with BRAF(V600E) mutation and its possible molecular mechanism. (2014)
  • Author(s): 1.Wakasa T, Li Y, Bai Y, Liu Z, Ozaki T, Mori I, Miyauchi A, Kakudo K, Nakamura M.
  • Journal Title: Pathol Res Pract. Volume: 210 Issue: 11 Pages: 733-8
  • DOI: 10.1016/j.prp.2014.06.025
  • Peer Reviewed
• [Journal Article] Procalcitonin : Mysterious protein in sepsis (2013)
  • Author(s): Misa Nakamura, Ryohei Kono, Sachiko Nomura, Hirotoshi Utsunomiya
  • Journal Title: Journal of Basic and Clinical Medicine Volume: 2 Pages: 7-11
  • Peer Reviewed
• [Journal Article] Procalcitonin : Mysterious Protein in Sepsis (2013)
  • Author(s): Misa Nakamura, Ryohei Kohono, Sachiko Nomura, Hirotoshi Utsunomiya
  • Journal Title: Journal of Basic and Clinical Medicine Volume: 2 Pages: 7-11
  • Peer Reviewed
• [Presentation] 薬剤としてのカルシトニンが腫瘍におよぼす効果 ―細胞内シグナル伝達と遺伝子発現を中心に― (2014)
  • Author(s): 中村美砂
  • Organizer: 日本内分泌病理学会 佐野賞受賞講演
  • Place of Presentation: 東京
  • Year and Date: 2014-11-01 – 2014-11-02
  • Invited