| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The synovial lining layer in the temporomandibular joint (TMJ) contains two types of synovial lining cells (SLC): a macrophage-like type A cell and fibroblast-like type B cell. The present study investigated the immunocytochemical characteristics of the SLC in adult rat TMJ, focusing on their possible participation in the synovial vasculature. The desmin-positive B cell resembles an activated pericyte during angiogenesis in both immunoreactivities and ultrastructure. They existed adjacent to the capillaries and RECA-1 (endothelial marker)-positive A cells. Lectin-perfusion represented the functional vessels in synovial membrane. Some capillaries with RECA-1-reaction lacked lectin-staining, indicating a loss of blood-circulation due to vessel sprouting. RECA-1 and desmin-positive SLC often attached to this portion. A few capillaries also expressed ninein (sprouting tip cell marker). These findings suggest that SLC might contribute to angiogenesis in the synovial membrane.
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