| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In this study, involvement of neurons and glial cells in the central nervous system in abnormal orofacial pain sensations after peripheral nerve injury was investigated. Differential changes in neuronal excitability in the brainstem were observed after trigeminal nerve injury. Established an objective method for assessing intraoral pain, I found that injury to the peripheral nerve exaggerated the behavioral responses and that convergent primary nociceptive input through neighboring intact nerves may contribute to the pathogenesis of neuropathic pain following trigeminal nerve injury. Furthermore, I confirmed the relationship between abnormal pain sensations and the convergence in the spinal cord following injury to the nerve innervating the hindpaw and found that microglial activation following peripheral nerve injury plays an important role in the anomalous convergence of nociceptive signals to spinal dorsal horn neurons and the development of neuropathic pain.
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