| Project/Area Number |
24592766
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Nihon University (2013-2015)
Okayama University (2012) |
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Principal Investigator |
TAMAMURA Ryo 日本大学, 松戸歯学部, 助教 (00403494)
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| Co-Investigator(Kenkyū-buntansha) |
NAGATSUKA Hitoshi 岡山大学, 大学院医歯薬学総合研究科, 教授 (70237535)
TSUJIGIWA Hidetsugu 岡山理科大学, 理学部, 教授 (70335628)
KATASE Naoki 川崎大学, 医学部, 助教 (30566071)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 口腔癌 / 扁平上皮癌 / 癌抑制遺伝子 / RIZ / Rap1GAP |
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| Outline of Final Research Achievements |
In the present research, we investigated the function of candidate tumor suppressor gene, RIZ in oral squamous cell carcinoma (OSCC). According to our gene analysis, no frameshift mutation but two polymorphisms were detected. There was no significant relation between any of the two polymorphisms and clinicopathological data or patient’s survival for OSCC. According to the immunohistochemistry by using anti-RIZ antibody, RIZ protein were expressed in not only OSCC but also precancerous lesion. It was suggested that RIZ protein played an important role in the carcinogenesis of OSCC, especially related at late stage.
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