| Project/Area Number |
24592769
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
NAGAMUNE Hideaki 徳島大学, ソシオテクノサイエンス研究部, 教授 (40189163)
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| Co-Investigator(Kenkyū-buntansha) |
TOMOYASU Toshifumi 徳島大学, 大学院ソシオテクノサイエンス研究部, 准教授 (20323404)
TABATA Atsushi 徳島大学, 大学院ソシオテクノサイエンス研究部, 助教 (10432767)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 連鎖球菌 / Streptococcus mitis / 毒素 / 病原性 / 薬剤耐性 |
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| Outline of Final Research Achievements |
In Streptococcus mitis (SM), an oral streptococcus generally recognized as low pathogenic species, the strains with plural cholesterol-dependent cytolysins (CDC) were identified. Therefore, we carried out the study on pathogenicity and epidemiology of SM strains including their comparative genome analysis. It was revealed that highly pathogenic SM (HPSM) strains with penicillin G-resistance (PR) and potent cytotoxicity against human cells by human-directed CDC were frequently isolated from the patients of pneumonia and Kawasaki disease. As the results of comparative genome analysis among Mitis group streptococci, it was shown that all loci of CDC genes were individually classified into several patterns and the genomic hybridization with related species probably occurred at the loci nearby CDC genes. Thus, it was suggested that HPSM occurred through further recombination within or among species after the first transmission of CDC genes, and PR mutations.
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