| Project/Area Number |
24592778
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
INAGAKI Satoru (20385165)
KOKUBU Eitoyo 東京歯科大学, 歯学部, 助教 (70453785)
KIKUCHI Yuichiro 東京歯科大学, 歯学部, 助教 (30410418)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Polymicrobial infection / バイオフィルム / 歯周炎 / 共凝集 / オートインデューサー / クオラムセンシング / デンタルプラーク / Porphyromonas gingivalis / Periodontal disease / Dental plaque / Biofilm / Treponema denticola / Coaggregation / Adherence / Quorum sensing |
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| Outline of Final Research Achievements |
Periodontitis is a typical polymicrobial infection. To clarify contribution of the bacterial interaction for development of periodontitis, we investigated the effect of co-culture of periodontopathic bacteria on virulence of each microorganisms. In the tested microorganisms, F. nucleatum enhanced biofilm formation by P. micra, which is predominant microorganism in apical periodontitis. In the combination of P. gingivalis and F. nucleatum, which are highly prevalent in chronic periodontitis, P. gingivalis enhanced biofilm formation by F. nucleatum, and F. nucleatum enhanced invasion of epithelial cells by P. gingivalis. These results suggest that enhancement of virulence by combination of the specific periodontopathic bacteria involves development of periodontitis.
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