| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
The goal of this study was to investigate the mechanism underling adhesion between the internal basal lamina and the mineralized enamel surface. Immunogold labeling was performed to localize amelotin and laminin 5 at the tooth/junctional epithelium interface.
The results show that laminin 5 is actively synthesized in junctional epithelial cells and that the products are incorporated into the internal basal lamina to maintain firm epithelial adhesion to the tooth enamel throughout life. On the other hand, amelotin molecules were preferentially localized on the tiny strands associated with basal lamina, suggesting that the molecules facilitate cell/enamel adhesion by promoting mineralization of the strands.
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