| Project/Area Number |
24592783
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Nihon Pharmaceutical University (2013-2014)
Tsurumi University (2012) |
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Principal Investigator |
INOUE HIROKO 日本薬科大学, 薬学部, 准教授 (50367306)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Ichiro 鶴見大学, 歯学部, 教授 (60147634)
MURAMATSU Takashi 東京歯科大学, 歯学部, 教授 (00276982)
RYO Kofuchi 鶴見大学, 歯学部, 講師 (10298268)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Epstein-Barr virus / シェーグレン症候群 / 自己抗体 / TLR / EBウイルス / EBER / SSB/La |
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| Outline of Final Research Achievements |
Sjogren's syndrome (SS) is an organ-specific autoimmune disease caused by the progressive loss of exocrine glands and is associated with several autoimmune phenomena. Several reports have suggested that reactivation of Epstein-Barr virus (EBV) may be a cause of SS. In this study, we revealed that EBV noncoding RNA, EBER, induced various cytokine in human salivary gland epithelial cell lines. In C57/B6 mice, nuclear extract (NE) from EBV infected B cell line induced expression of autoantibody, anti-SSB/La. Moreover, in NZW/NZB F1 mice, recombinant EBER induced anti-SSB/La antibody more efficiently than poly(I:C), TLR ligand.
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