| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Osteoblast differentiation is a multistep pathway in which multipotential mesenchymal cells differentiate into osteoblasts. The transcription factor Osterix (Osx) regulates osteoblast differentiation and bone-specific gene expression. However, Osx expression is detected not only in osteogenic tissue but also in chondrogenic tissues, suggesting the presence of molecules required to control osteogenesis by Osx. In the current studies, we have analyzed possible Osx partner molecules Osx coactivator 1 (OSC1) and Osx coactivator 2 (OSC2). The results suggest that the two molecules associate with Osx as a coactivator during osteoblast differentiation. Expression of OSC1 is induced during osteoblast differentiation in vitro. OSC1 and OSC2 directly interact with Osx and promote Osx-dependent transcriptional activity, suggesting that OSCs act as a transcriptional coactivator for Osx. Our results provide new insights into a transcriptional regulation of osteoblast differentiation by Osx.
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