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The effect of SUMOylation on bone formation in mouse

Research Project

Project/Area Number 24592787
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Morphological basic dentistry
Research InstitutionShizuoka University (2013-2014)
Matsumoto Dental University (2012)

Principal Investigator

AKIRA Yukita  静岡大学, 教育学部, 講師 (80401214)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Hiroaki  松本歯科大学, 歯学部, 教授 (50227930)
HOSOYA Akihiro  松本歯科大学, 歯学部, 講師 (70350824)
Co-Investigator(Renkei-kenkyūsha) ITO Yuzuru  産業技術総合研究所, 幹細胞工学研究センター, 研究チーム長 (30500079)
HOSOYA Akihiro  松本歯科大学, 歯学部, 教授 (20264252)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords骨芽細胞分化 / SUMO化修飾 / 分化制御 / 培養細胞 / Osterix / BMP / 骨芽細胞 / 遺伝子改変マウス / Osterix / SUMO
Outline of Final Research Achievements

We investigated the effect of SUMOylation on BMP-induced osteoblastic differentiation using various cell lines. Inhibition of SUMOylation suppressed the osteoblastic differentiation induced by BMP treatment in the MC3T3E1 cells, which derived from mouse calvaria, while enhanced it in ST2 mouse bone marrow derived stromal cells and murine fibroblasts (C3H10T1/2 cells). This Data shows that the effect of SUMOylation on osteoblastic differentiation might change depending on degree of osteoblasts.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (4 results)

All 2014 2012

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (1 results)

  • [Journal Article] Two distinct processes of bone-like tissue formation by dental pulp cells after tooth transplantation.2012

    • Author(s)
      Hosoya A et al.
    • Journal Title

      J Histochem Cytochem

      Volume: 60 Issue: 11 Pages: 861-873

    • DOI

      10.1369/0022155412459741

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ubc9 negatively regulates BMP-mediated osteoblastic differentiation in cultured cells2012

    • Author(s)
      Yukita A, Hosoya A, Ito Y, Katagiri T, Asashima M, Nakamura H
    • Journal Title

      Bone

      Volume: 50 Issue: 5 Pages: 1092

    • DOI

      10.1016/j.bone.2012.02.008

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Thy-1-positive cells in the subodontoblastic layer possess high potential to differentiate into hard tissue-forming cells.2012

    • Author(s)
      Hosoya A, Hiraga T, Ninomiya T, Yukita A, Yoshiba K, Yoshiba N, Takahashi M, Ito S, Nakamura H.
    • Journal Title

      Histochem Cell Biol

      Volume: 137(6) Issue: 6 Pages: 733-42

    • DOI

      10.1007/s00418-012-0928-1

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] SUMO化修飾阻害によるBMP誘導性骨芽細胞分化の促進2014

    • Author(s)
      堀池俊秀、雪田 聡
    • Organizer
      日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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