| Project/Area Number |
24592795
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Niigata University (2013-2014)
Osaka University (2012) |
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Principal Investigator |
SAEKI Makio 新潟大学, 医歯学系, 教授 (30273692)
|
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| Co-Investigator(Kenkyū-buntansha) |
上崎 善規 大阪大学, 歯学研究科(研究院), 名誉教授 (40116017)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
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| Keywords | R2TP / Monad / mTOR / Tumorigenesis / PIH1D1 / ｍＴＯＲ / RPAP3 / breast cancer / invasion |
|---|
| Outline of Final Research Achievements |
R2TP was originally identified in yeast Saccharomyces cerevisiae as Hsp90 interacting complex, and is composed of four different proteins: Rvb1, Rvb2, Tah1, and Pih1. This complex is well-conserved in eukaryotes, and is involved in many cellular processes such as snoRNP biogenesis, RNA polymerase assembly, PIKK signaling, and apoptosis. An increasing number of research related
to R2TP suggests a linkage of its function with tumorigenesis. We provide an overview of several recent studies on R2TP that are related to cell proliferation and carcinogenesis, and propose a possible role of R2TP in tumorigenesis through regulating snoRNA/snoRNP biogenesis.
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