Roles of TASK channels in the modulation of jaw-closing motoneuron activity
| Project/Area Number |
24592797
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Functional basic dentistry
|
|---|
| Research Institution | Kagoshima University (2015)
Osaka University (2012-2014) |
|---|
Principal Investigator |
Saito Mitsuru 鹿児島大学, 医歯学域歯学系, 教授 (50347770)
|
|---|
| Project Period (FY) |
2012-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 口腔生理学 / 咬合 / 閉口筋 / 運動単位 / 序列動員 / 張力調節 / TASKチャネル / 三叉神経 / α運動ニューロン / γ運動ニューロン / 等尺性筋収縮 / 運動ニューロン / 漏洩コンダクタンス / 筋紡錘 / サイズの原理 / 等尺性収縮 / 光遺伝学 |
|---|
| Outline of Final Research Achievements |
The mastication of foods occurs during the slow-closing phase of the mastication cycle, in which isometric contraction of jaw-closing muscles is developed through the rank-ordered recruitment of jaw-closing motoneurons (MNs). However, its molecular mechanism remains unknown. Here we show that TWIK-related acid-sensitive K+ channel-1 (TASK1) and TASK3 channels, which determine the input resistance and resting membrane potential, are differentially expressed between small and large MNs and play critical roles in the rank-ordered recruitment of jaw-closing MNs. The principle of the rank-ordered recruitment was originally proposed based on the conduction velocity of the motor nerve fibers innervating a set of muscle fibers. After a half-century, we for the first time disclosed the molecular mechanism for the rank-ordered recruitment of jaw-closing MNs.
|
Report
(5 results)
Research Products
(36 results)
-
-
-
-
[Journal Article] Generation of resonance-dependent oscillation by mGluR-I activation switches single spiking to bursting in mesencephalic trigeminal sensory neurons2015
Author(s)
Chung, G., Saito, M., Kawasaki, Y., Kawano, T., Yin, D., Lee, S., Kogo, M., Takada, M., Bae, Y., Oh, S.B & Kang, Y.
-
Journal Title
European Journal of Neuroscience
Volume: 41
Issue: 8
Pages: 998-1012
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
[Journal Article] Enhanced desensitization followed by unusual resensitization in GABAA receptors in phospholipase C-related catalytically inactive protein-1/2 double-knockout mice2014
Author(s)
Toyoda, H., Saito, M., Sato, H., Tanaka, T., Ogawa, T., Yatani, H., Kawano, T., Kanematsu, T., Hirata, M. & Kang, Y.
-
Journal Title
Pflugers Archiv - European Journal of Physiology
Volume: in press
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
