| Project/Area Number |
24592802
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
TAKE Hiro 九州大学, 歯学研究科(研究院), 准教授 (10420598)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI Hiroshi 九州大学, 歯学研究院, 教授 (20155774)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 歯周病 / ミクログリア / 髄膜 / アルツハイマー病 / 歯周病菌LPS / 髄膜細胞 / IL-1 b / 脳炎症 / pgLPS / TLR2 / パラインフラメーション |
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| Outline of Final Research Achievements |
Recently, Periodontitis has been accepted as a risk factor of Alzheimer’s disease. In the current study, we investigate the possibility and the mechanism of our hypothesis, which「Periodontitis, as a long term of low-grade systemic inflammation, can induces a breakdown of meningeal-glial protective system in brain, result in neuroinflammation-related memory loss」. We found that Periodontists bacteria (Porphyromonas Gingivalis, PG) and it LPS (PGLPS) induced a TLR2 dependent inflammatory mediator production by meningeal cells to activate microglia, resulting in impairment of learning and memory in the middle-aged mice. Moreover, the amplifying of microglia response with aging is a risk factor for neuroinflammation in Aβ dependent manner in the brain of Alzheimer’s disease.
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