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Change of taste sensitivity due to daily intake of sweet solution

Research Project

Project/Area Number 24592803
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional basic dentistry
Research InstitutionKyushu University

Principal Investigator

NAKANO Keiko  九州大学, 味覚・嗅覚センサ研究開発センター, 准教授 (50380704)

Co-Investigator(Renkei-kenkyūsha) NINOMIYA Yuzo  九州大学, 大学院歯学研究院, 教授 (50076048)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords味覚 / 鼓索神経 / 舌咽神経 / 甘味 / 生活習慣 / 味覚異常
Outline of Final Research Achievements

It is unknown whether habitual intake of sweet beverages causes change of taste sensitivity. To examine taste sensitivity after daily intake of sweet solution, we recorded whole nerve responses in the chorda tympani and glossopharyngeal nerves after mice were given 2 mM saccharin instead of water.
Responses to sweet compounds were significantly changed as compare with control mice that were given water. Concomitantly, it was suggested that the expression revel of T1R3 mRNA was changed in accordance with change of sweet taste responses.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (21 results)

All 2015 2014 2013 2012 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (12 results) (of which Invited: 2 results) Remarks (2 results)

  • [Journal Article] Modulation of sweet taste sensitivities by endogenous leptin and endocannabinoids in mice.2015

    • Author(s)
      Niki M, Jyotaki M, Yoshida R, Yasumatsu K, Shigemura N, DiPatrizio NV, Piomelli D, Ninomiya Y.
    • Journal Title

      J Physiol.

      Volume: Feb 25 Issue: 11 Pages: 1-48

    • DOI

      10.1113/jp270295

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glucagon like peptide-1 is specifically involved in sweet taste transmission2015

    • Author(s)
      Shingo Takai, Keiko Yasumatsu, Mayuko Inoue Shusuke Iwata, Ryusuke Yoshida, Noriatsu Shigemura, Yuchio Yanagawa, Daniel J. Drucker, Robert F. Margolskee, Yuzo Ninomiya
    • Journal Title

      The FASEB Journal

      Volume: Vol. 29 Issue: 6 Pages: 1-13

    • DOI

      10.1096/fj.14-265355

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Involvement of multiple taste receptors in umami taste: analysis of gustatory nerve responses in metabotropic glutamate receptor 4 knockout mice.2015

    • Author(s)
      Yasumatsu K, Manabe T, Yoshida R, Iwatsuki K, Uneyama H, Takahashi I, Ninomiya Y.
    • Journal Title

      J Physiol.

      Volume: 593(4) Issue: 4 Pages: 1021-1034

    • DOI

      10.1113/jphysiol.2014.284703

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Activation of tongue-expressed GPR40 and GPR120 by non caloric agonists is not sufficient to drive preference in mice2013

    • Author(s)
      Godinot N, Yasumatsu K, Barcos ME, Pineau N, Ledda M, Viton F, Ninomiya Y, le Coutre J, Damak S
    • Journal Title

      Neuroscience

      Volume: 250 Pages: 20-30

    • DOI

      10.1016/j.neuroscience.2013.06.043

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II modulates salty and sweet taste sensitivities2013

    • Author(s)
      N Shigemura, S Iwata, K Yasumatsu, T Ohkuri, N Horio, et al
    • Journal Title

      Journal of Neuroscience

      Volume: 33(15) Issue: 15 Pages: 6263-6277

    • DOI

      10.1523/jneurosci.5599-12.2013

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Taste responses in mice lacking taste receptor subunit T1R12013

    • Author(s)
      Kusuhara Y, Yoshida R, Ohkuri T, Yasumatsu K, Voigt A, Hübner S, Maeda K, Boehm U, Meyerhof W, Ninomiya Y
    • Journal Title

      J Physiol

      Volume: 591 Issue: 7 Pages: 1967-85

    • DOI

      10.1113/jphysiol.2012.236604

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Umami taste in mice uses multiple receptors and transduction pathways2012

    • Author(s)
      Yasumatsu K, et al
    • Journal Title

      The Journal of Physiology

      Volume: 590 Issue: 5 Pages: 1155-1170

    • DOI

      10.1113/jphysiol.2011.211920

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 甘味溶液継続摂取マウスにおける鼓索神経全線維束応答の解析2014

    • Author(s)
      安松啓子、高井信吾、吉田竜介、硲 哲崇、二ノ宮裕三
    • Organizer
      日本味と匂学会第48回大会
    • Place of Presentation
      静岡県清水市
    • Year and Date
      2014-10-02 – 2014-10-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Glucagon like peptide-1(GLP-1) underlies sweet taste transmission2014

    • Author(s)
      Takai S, Yasumatsu K, Iwata S, Inoue M, Yoshida R, Shigemura N, Ninomiya Y
    • Organizer
      Jpn Assoc. Study of Taste & Smell 2014, Young Researchers’ SEMINAR
    • Place of Presentation
      静岡県清水市
    • Year and Date
      2014-10-02 – 2014-10-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 甘味溶液継続摂取マウスにおける鼓索神経および舌咽神経全線維束応答の解析2014

    • Author(s)
      安松啓子、硲 哲崇、二ノ宮裕三
    • Organizer
      第56回歯科基礎医学会学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 味蕾から分泌される GLP-1 は甘味特異的な情報伝達に関与する2014

    • Author(s)
      髙井信吾, 安松啓子, 岩田周介, 井上真由子, 吉田竜介, 重村憲徳, Drucker DJ, Margolskee RF, 二ノ宮裕三
    • Organizer
      第56回歯科基礎医学会学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Analysis of whole nerve responses in the chorda tympani nerve from mice after daily intake of sweet solution2014

    • Author(s)
      Keiko Yasumatsu, Noritaka Sako, Yuzo Ninomiya
    • Organizer
      european chemoreception research organization (ECRO)
    • Place of Presentation
      Dijon, France
    • Year and Date
      2014-09-10 – 2014-09-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Functional analysis of umami receptors in the chorda tympani and glossopharyngeal nerves from mGluR4 knockout mice2013

    • Author(s)
      Keiko Yasumatsu, Tomohiro Manabe, Noriatsu Shigemura, Ken Iwatsuki, Ichiro Takahashi, Hisayuki Uneyama, Yuzo Ninomiya
    • Organizer
      ECRO
    • Place of Presentation
      Leuven
    • Related Report
      2013 Research-status Report
  • [Presentation] mGluR4-KOマウスの鼓索神経および舌咽神経におけるうま味応答の解析2013

    • Author(s)
      安松啓子、真鍋智宏、岩槻健 、高橋一郎、畝山寿之、二ノ宮裕三
    • Organizer
      日本味と匂学会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] mGluR4ノックアウトマウスの鼓索神経および舌咽神経におけるうま味受容体の機能解析2013

    • Author(s)
      安松啓子、重村憲徳、二ノ宮裕三
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      岡山
    • Related Report
      2013 Research-status Report
  • [Presentation] mGluR4-KOマウスの鼓索神経および舌咽神経におけるうま味応答の解析2012

    • Author(s)
      安松啓子、真鍋智宏、岩槻健、高橋一郎、畝山寿久、二ノ宮裕三
    • Organizer
      日本味と匂学会第46回大会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
  • [Presentation] ベンゼトニウム塩化物、グルコン酸クロルヘキシジン、アクリノール水和物の舌処理による鼓索神経応答変化の比較2012

    • Author(s)
      谷口敬祐、安松啓子、安尾敏明、式守道夫、硲哲崇
    • Organizer
      日本味と匂学会第46回大会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
  • [Presentation] スペアミントによる味覚抑制はカルボンに起因する2012

    • Author(s)
      硲哲崇、安松啓子、坂井信之、池西岳樹、新倉祐司、萩森夏芽
    • Organizer
      日本味と匂学会第46回大会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
  • [Presentation] 味覚情報伝達物質候補の血中投与によるマウス鼓索神経活動変化について2012

    • Author(s)
      八坂美沙、仁木麻由、安松啓子、中村誠司、二ノ宮裕三
    • Organizer
      日本味と匂学会第46回大会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
  • [Remarks] 味覚・嗅覚センサ研究開発センター 原著論文

    • URL

      http://www.rdctos.kyushu-u.ac.jp/accomplishments/detail0140.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 味覚・嗅覚センサ研究開発センター 招待講演

    • URL

      http://www.rdctos.kyushu-u.ac.jp/accomplishments/detail0148.html

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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