| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
This study revealed the following:(i) PRIP, an inositol 1,4,5-trisphosphate binding and signaling molecule, is positively involved in the regulation of a signaling molecule, Smad6 which inhibits BMP signaling through the binding to BMP receptors or the interference of Smad1/5 phosphorylation. (ii) PRIP functions as a regulator of osteoclast differentiation at early stage, probably through the regulation of the expression and/or activity of a serin/threonine phosphoatage, calcineurin.
It was indicated that the deficiency of these functions cause the increased bone mineral density and trabecular bone volume in PRIP knockout mice.
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