Study on a novel mechanism of bone metabolism implicating the function of a signaling molecule, PRIP
| Project/Area Number |
24592804
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
MATSUDA Miho 九州大学, 歯学研究科(研究院), 助教 (40291520)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 骨代謝 / 骨形成 / BMP / 骨吸収 / M-CSF / PRIP / BMPシグナリング / Smad / 細胞分化 / カルシニューリン / 骨芽細胞 / 破骨細胞 / MCSF |
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| Outline of Final Research Achievements |
This study revealed the following:(i) PRIP, an inositol 1,4,5-trisphosphate binding and signaling molecule, is positively involved in the regulation of a signaling molecule, Smad6 which inhibits BMP signaling through the binding to BMP receptors or the interference of Smad1/5 phosphorylation. (ii) PRIP functions as a regulator of osteoclast differentiation at early stage, probably through the regulation of the expression and/or activity of a serin/threonine phosphoatage, calcineurin.
It was indicated that the deficiency of these functions cause the increased bone mineral density and trabecular bone volume in PRIP knockout mice.
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Report
(4 results)
Research Products
(18 results)
