Visualization of Neural circuits controlling feeding behavior
| Project/Area Number |
24592818
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TAMURA Takuya 東京医科歯科大学, 難治疾患研究所, 助教 (80396647)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 神経回路 / 化学感覚 / 感覚 |
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| Outline of Final Research Achievements |
To visualize central neurons responsible for taste perception, we made transgenic animals expressing thermo-sensitive TRP ion channel (dTRPA) in taste cells. Heat stimulation of the sweet- and bitter-cells induced different patterns of ERK phosphorylation in the subesophageal ganglion. In addition, we tried to identify the neurons controlling feeding behavior using enhancer trap lines expressing sodium channel in a subset of neurons in the brain. We found that excitability of subset of dopaminergic neurons modulates the feeding behavior.
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Report
(4 results)
Research Products
(7 results)
