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Visualization of Neural circuits controlling feeding behavior

Research Project

Project/Area Number 24592818
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional basic dentistry
Research InstitutionNihon University

Principal Investigator

KONDO Masahiro  日本大学, 歯学部, 講師 (50312294)

Co-Investigator(Renkei-kenkyūsha) TAMURA Takuya  東京医科歯科大学, 難治疾患研究所, 助教 (80396647)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords神経回路 / 化学感覚 / 感覚
Outline of Final Research Achievements

To visualize central neurons responsible for taste perception, we made transgenic animals expressing thermo-sensitive TRP ion channel (dTRPA) in taste cells. Heat stimulation of the sweet- and bitter-cells induced different patterns of ERK phosphorylation in the subesophageal ganglion. In addition, we tried to identify the neurons controlling feeding behavior using enhancer trap lines expressing sodium channel in a subset of neurons in the brain. We found that excitability of subset of dopaminergic neurons modulates the feeding behavior.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (7 results)

All 2014 2013 2012 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (4 results)

  • [Journal Article] Morphological and functional changes in regenerated primary afferent fibres following mental and inferior alveolar nerve transection2014

    • Author(s)
      Tsuboi Y, Honda K, Bae YC, Shinoda M, Kondo M, Katagiri A, Echizenya S, Kamakura S, Lee J, Iwata K.
    • Journal Title

      Eur J Pain

      Volume: - Issue: 9 Pages: 1258-1266

    • DOI

      10.1002/ejp.650

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ERK is involved in tooth-pressure-induced Fos expression in Vc neurons2012

    • Author(s)
      Hasegawa M, Kondo M* et al.
    • Journal Title

      J Dent Res

      Volume: 91(12) Issue: 12 Pages: 1141-1146

    • DOI

      10.1177/0022034512462397

    • Related Report
      2012 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of AMPA Receptor GluR2 and GluR3 Trafficking in Trigeminal Spinal Subnucleus Caudalis and C1/C2 Neurons in Acute-Facial Inflammatory Pain.2012

    • Author(s)
      Miyamoto, M.
    • Journal Title

      PLoS One

      Volume: 7 Issue: 8 Pages: e44055-e44055

    • DOI

      10.1371/journal.pone.0044055

    • Related Report
      2012 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 細胞接着分子Dscamの過剰発現により生じる感覚ニューロンの軸索投射異常2013

    • Author(s)
      近藤真啓
    • Organizer
      第6回分子高次機能研究会
    • Place of Presentation
      軽井沢ホテル(長野県)
    • Related Report
      2013 Research-status Report
  • [Presentation] Extracellular signal-regulated kinase phosphorylation in trigeminal spinal nucleus and upper cervical spinal cord neurons induced by experimental tooth movement

    • Author(s)
      Shibuta K
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2012 Research-status Report
  • [Presentation] Overexpression of Dscam leads to axonal targeting defects in the Drosophila sensory neurons

    • Author(s)
      Kondo M
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      マリンメッセ福岡(福岡)
    • Related Report
      2012 Research-status Report
  • [Presentation] Neuronal Ig receptors control neural wiring specificity and feeding behavior in Drosophila

    • Author(s)
      Kondo M
    • Organizer
      10th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception (YR Umami Forum 2012)
    • Place of Presentation
      九州大学馬出キャンパスコラボレーションセンター(福岡)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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