Role of BDNF on the excitability of trigeminal ganglion neurons involved in inflammatory hyperalgesia

• Project/Area Number: 24592819
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Functional basic dentistry
• Research Institution: Azabu University (2014); The Nippon Dental University (2012-2013)
• Principal Investigator: TAKEDA Mamoru 麻布大学, その他部局等, 教授 (20227036)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 三叉神経節ニューロン / BDNF / パラクリン / 炎症 / パッチクランプ法 / 免疫組織化学 / 電気泳動的投与 / 細胞外記録 / 痛覚 / 三叉神経節 / 神経栄養因子 / パッチクランプ / 蛍光標識法 / 免疫組織化学法

Outline of Final Research Achievements

Present study investigated that the functional significance of hyperalgesia to the brain-derived neurotrophic factor (BDNF) tyrosine linase B (trkB) signaling system in trigeminal ganglion (TRG) neurons projecting to the trigeminal subnuclei interpolaris/ caudalis (Vi/Vc) transition region following masseter muscle inflammation under in vivo and in vitro conditions. We found that BDNF enhances the excitability of small –diameter TRG neurons projecting onto the Vi/Vc following masseter muscle inflammation. Thus, these findings suggest that ganglionic BDNF-trk B signaling is therapeutic targets for the treatment for trigeminal inflammatory hyperalgesia

Research Products

• [Journal Article] Inflammation enhanced brain-derived neurotrophic factor-induced suppression of voltage-gated potassiun currents in small-diameter trigeminal ganglion neurons projecting to the trigeminal nucleus interpolaris/caudalis transition zone. (2014)
  • Author(s): M.Takeda, M.Takahashi, S. Matsumoto
  • Journal Title: Neuroscience Volume: 261 Pages: 223-231
  • DOI: 10.1016/j.neuroscience.2013.12.048
  • Peer Reviewed
• [Journal Article] Brain-derived neurotrophic factor enhances the excitability of small-diameter trigeminal ganglion neurons projecting to the trigeminal nucleus interpolaris/caudalis transition zone following masseter muscle inflammation. (2013)
  • Author(s): Takeda M, Takahashi M, Kitagawa J, Kanazawa T, Nasu M, Matsumoto S.
  • Journal Title: Mol Pain. Volume: 9 Pages: 49-49
  • DOI: 10.1186/1744-8069-9-49
  • Peer Reviewed
• [Presentation] Brain-derived neurotrophic factor enhances the excitability of small-diameter trigeminal ganglion neurons projecting to teh trigeminal nucleus interpolaris/caudalis trnsition zone following masseter muscle inflammation (2014)
  • Author(s): M. Takeda, M. Takahashi, T, Kanazawa, M . Nasu, Y. Shimazu, S. Matsumoto
  • Organizer: Neurosicence 2014 （第３７回日本神経科学大会）
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-09-11 – 2014-09-13