• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Activation of Wnt/beta-catenin signaling by the loss of p63 in malignant oral cancers

Research Project

Project/Area Number 24592827
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

KURATA Shun-ichi  東京医科歯科大学, 難治疾患研究所, 准教授 (60140901)

Co-Investigator(Renkei-kenkyūsha) HATA Ryu-Ichiro  神奈川歯科大学, 歯学部, 特任教授 (10014276)
KATOH Iyoko  山梨大学, 大学院総合研究部 (20333297)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsp63 / 扁平上皮癌 / p63 / Wnt / TP63 / 口腔癌
Outline of Final Research Achievements

TP63 (p63), a member of the tumor suppressor TP53 (p53) gene family, is essential for development of ectodermal tissues including skin and head-and-neck. Although p63 is highly expressed in well-differentiated oral carcinomas, it disappears in invasive cancers, leading to the hypothesis that p63 suppresses malignant conversion. We studied how p63 controls the Wnt/beta-catenin signaling pathway in oral carcinoma cell lines by analyzing the pathway proteins as well as the target gene expression. The results indicate that the major p63 protein, DeltaNp63alpha, represses Wnt/beta-catenin target gene expression, by interacting with TCF-4, a Wnt target sequence-specific DNA binding protein. Malignant progression of oral cancers may be blocked by this function of p63.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (9 results)

All 2014 2013 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) Remarks (1 results)

  • [Journal Article] Atrial natriuretic peptide attenuates kidney-lung crosstalk in kidney injury2014

    • Author(s)
      Tulafu M, Mitaka C, Hnin Si MK, Abe S, Kitagawa M, Ikeda S, Eishi Y, Kurata S, Tomita M
    • Journal Title

      J Surg Res

      Volume: 186 Issue: 1 Pages: 217-225

    • DOI

      10.1016/j.jss.2013.07.033

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Inhibition of poly (adenosine diphosphate-ribose) polymerase attenuates lung-kidney crosstalk induced by intratracheal lipopolysaccharide instillation in rats2013

    • Author(s)
      Si MK, Mitaka C, Tulafu M, Abe S, Kitagawa M, Ikeda S, Eishi Y, Kurata S, Tomita M.
    • Journal Title

      Respiratory Research

      Volume: 14 Issue: 1 Pages: 126-133

    • DOI

      10.1186/1465-9921-14-126

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of endogenous retroviruses and long terminal repeats with human disorders2013

    • Author(s)
      Katoh I, Kurata S
    • Journal Title

      Frontiers in Oncology

      Volume: 3 Pages: 1-8

    • DOI

      10.3389/fonc.2013.00234

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] p63(TP63)によるWnt標的遺伝子の正と負の制御2014

    • Author(s)
      倉田俊一、福西菜穂子、藤室雅弘、加藤伊陽子
    • Organizer
      日本生化学会大会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Detection of the import of procaspase-9 into the mitochondrial intermembrane space

    • Author(s)
      Katoh I, Kurata S
    • Organizer
      第86回 日本生化学会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] p63による新規Wnt/beta-cateninシグナル活性化機構

    • Author(s)
      加藤伊陽子、福西菜穂子、藤室雅弘、畑隆一郎、倉田俊一
    • Organizer
      第72回 日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] p63 enhances Wnt target gene expression by nuclear complex formation with beta-catenin and TCF.

    • Author(s)
      Iyoko Katoh, Nahoko Fukunishi, Ryu-Ichiro Hata, Shun-ichi Kurata
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 倉田俊一 福西菜穂子 畑 隆一郎 加藤 伊陽子

    • Author(s)
      p63はWntシグナル標的遺伝子発現を活性化する
    • Organizer
      第85回日本生化学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Remarks] レドックス応答細胞生物学ホームページ(研究内容)

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi