Inhibition of SCC proliferation and metastases with targeting aquaporin

• Project/Area Number: 24592831
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Osaka University
• Principal Investigator: TANIGUCHI Yoshitaka 大阪大学, 歯学研究科(研究院), 招聘教員 (10551468)
• Co-Investigator(Kenkyū-buntansha): OKURA Masaya 大阪大学, 大学院歯学研究科, 准教授 (10281130) ; WADA Koichiro 鳥取大学, 医学部, 教授 (90263467)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 扁平上皮癌 / アクアポリン / 脂肪酸結合たんぱく質 / 口腔がん / 脂肪酸結合蛋白 / FABP / 増殖 / 浸潤 / 転移 / Aquaporin / 異所性発現

Outline of Final Research Achievements

Expression of aquaporin 3, 5 in oral squamous cell carcinoma (SCC) was much higher, whereas it in normal epithelium was null, suggesting ectopic expression of aquaporins in oral SCC. Knock-down of aquaporins in oral SCC cell lines resulted in the inhibition of cell proliferation. Moreover, we detected fatty acid-binding protein (FABP) in SCC prolireration. FABPs were expressed highly in oral SCC ectopically. FABP has an important role in proliferation of SCC through the MAPK pathway.

Research Products

• [Journal Article] Expression of fatty acid binding protein 4 is involved in the cell growth of oral squamous cell carcinoma (2014)
  • Author(s): Lee D, Wada K, Taniguchi Y, Al-Shareef H, Masuda T, Usami Y, Aikawa T, Okura M, Kamisaki Y, Kogo M
  • Journal Title: Oncology Reports Volume: 31 Issue: 3 Pages: 1116-20
  • DOI: 10.3892/or.2014.2975
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Differential expression of aquaporin 5 and aquaporin 3 in squamous cell carcinoma and adenoid cystic carcinoma. (2012)
  • Author(s): Ishimoto S, Wada K, Usami Y, Tanaka N, Aikawa T, Okura M, Nakajima A, Kogo M, Kamisaki Y
  • Journal Title: Int J Oncol Volume: 41 Pages: 67-75
  • DOI: 10.3892/ijo.2012.1445
  • Peer Reviewed
• [Presentation] 口腔扁平上皮癌におけるfatty acid binding proteins（FABPs）の役割について (2014)
  • Author(s): 李 篤史, 谷口 佳孝, 大倉 正也, 相川 友直, 古郷 幹彦
  • Organizer: 第68回 日本口腔科学会
  • Place of Presentation: 京王プラザ
  • Year and Date: 2014-05-07 – 2014-05-09
• [Presentation] Ectopic expression of fatty acid binding protein 4 is involved in cell growth of lingual squamous cell carcinoma (2013)
  • Author(s): Doksa Lee, Koichiro Wada, Yoshitaka Taniguchi, Tomonao Aikawa, Masaya Okura, Yoshinori Kamisaki, Mikihiko Kogo
  • Organizer: The 21st edition of the International Conference on Oral and Maxillofacial Surgery
  • Place of Presentation: Barcelona, Spain
• [Presentation] 口腔扁平上皮癌におけるfatty acid binding protein4 (FABP4)の役割について (2013)
  • Author(s): 李 篤史、谷口 佳孝、大倉 正也、相川 友直、古郷 幹彦
  • Organizer: 第58回日本口腔外科学会総会
  • Place of Presentation: 福岡
• [Presentation] Ectopic expression of fatty acid binding protein 4 is involved in cell growth of lingual squamous cell carcinoma. (2013)
  • Author(s): Doksa Lee, Koichiro Wada, Yoshitaka Taniguchi, Tomonao Aikawa, Masaya Okura, Yoshinori Kamisaki, Mikihiko Kogo.
  • Organizer: The 21st edition of the International Conference on Oral and Maxillofacial Surgery.
  • Place of Presentation: Barcelona, Spain