Molecular characterization of the pathogenic factors of oral streptococci involved in autoimmune disease
| Project/Area Number |
24592833
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
HIROTA Katsuhiko 徳島大学, ヘルスバイオサイエンス研究部, 准教授 (60199130)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAKE Yoichiro 徳島大学, 大学院ヘルスバイオサイエンス, 教授 (80136093)
MURAKAMI Keiji 徳島大学, 大学院ヘルスバイオサイエンス研究部, 助教 (10335804)
OKAMURA Hirohiko 徳島大学, 大学院ヘルスバイオサイエンス研究部, 助教 (20380024)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | PAMPs / 自己免疫疾患 / バイオフィルム / IP-10 / CCL2 / CCL4 / ケモカイン / サイトカイン / ヘパリン / ヘパラン硫酸 / vesicle / 糖尿病 / ミトコンドリア / 自己抗体 / 膵β細胞 / CXCL10 / PBC / IL-8 / THP-1 |
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| Outline of Final Research Achievements |
Using genome microarray to define the gene expression profile of rSi-HLP-stimulated THP-1 cells, 83 genes were up-regulated (two fold higher) among 28,869 genes profiled. Especially, genes coding for chemokines and pro-inflammatory cytokines, such as CCL2, 3, 4, CXCL8, 10 were the most highly up-regulated groups. Recombinant Streptococcus intermedius histone-like DNA binding protein is one of the set Inducer excessive CXCL10, CXCL 8, CCL2, CCL3, CCL4 from human THP-1 cells.
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Report
(4 results)
Research Products
(12 results)
