| Project/Area Number |
24592834
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Kyushu University |
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Principal Investigator |
CHIKUI Toru 九州大学, 歯学研究科(研究院), 准教授 (10295090)
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| Co-Investigator(Kenkyū-buntansha) |
TOKUMORI Kenji 帝京大学, 准教授 (40253463)
KAWAZU Toshiyuki 九州大学, 大学病院, 助教 (20294960)
YOSHIURA Takashi 鹿児島大学, 医歯(薬)学総合研究科, 教授 (40322747)
HIWATASHI Akio 九州大学, 大学病院, 助教 (30444855)
KAMI Yukiko 九州大学, 大学院歯学研究院, 助教 (60552023)
KAWANO Shintarou 九州大学, 大学病院, 助教 (00398067)
YOSHIURA Kazunori 九州大学, 大学院歯学研究院, 教授 (20210643)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | dynamic撮像 / コンパートメントモデル / 細胞外血管外腔 / Ktrans / スピンラベリング / ダイナミックMRI / permeability / 薬物動態解析 / 造影剤 / perfusion / 動脈入力関数 / モデル解析 |
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| Outline of Final Research Achievements |
We performed compartment model analysis on the basis of the DCE-MRI. The arterial input function was estimated using phase images. We obtained the influx forward volume transfer constant (Ktrans), the fractional volume of extravascular extracellular space (ve) and the fractional volume of plasma (vp).The pleomorphic adenoma had lower Ktrans than malignant tumors. The ve was characteristic parameters among the tumors. Pleomorphic adenoma has a characteristic large ve value, while malignant lymphoma has characteristically small ve. In the oral squamous cell carcinoma, a decrease in the Ktrans at the primary site was found in advanced N stage cases, which might indicate that the hypoxic status cause a high possibility of the metastasis.
For the evaluation of arterial spin labeling, we estimated the relative blood flow (r BF). There was significant correlation between r BF and Ktrans and between r BF and Ktrans. However, some lesions could not identified on r BF map.
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