Establishment of non-invasive image diagnosis of Sjogren's syndrome using near-infrared spectrometer, MRI and sonography
| Project/Area Number |
24592835
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAZU Toshiyuki 九州大学, 大学病院, 助教 (20294960)
OKAMURA Kazutoshi 九州大学, 歯学研究院, 助教 (20346802)
OHYAMA Yukiko 九州大学, 歯学研究院, 助教 (70294957)
MORIYAMA Masafumi 九州大学, 歯学研究院, 助教 (20452774)
ABE Koichiro 九州大学, 大学病院, 講師 (00380387)
BABA Shingo 九州大学, 大学病院, 講師 (80380450)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 近赤外線 / MR-sialography / 超音波 / 唾液腺シンチグラフィー / シェーグレン症候群 / 非侵襲 |
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| Outline of Final Research Achievements |
We performed an experimental study for establishing non-invasive image diagnosis of Sjogren’s syndrome (SS). The tendency of an elevation of oxy-hemoglobin after acid stimulation was observed using near-infrared spectrometer in the parotid glands. However, it did not correlate with the degree of gland damage. Moreover, we could not obtain similar results even in the same patients. Motion sensitized driven equilibrium (MSDE) method on MRI could not offer better images. Dynamic curve analysis on the conventional salivary gland scintigraphy showed significant differences between SS and non-SS in every calculated value in the submandibular glands. Therefore, diagnostic criteria on salivary gland scintigraphy should be established based on the values in the submandibular glands.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Clinical characteristics of Mikulicz's disease as an IgG4-related disease.2013
Author(s)
4. Moriyama M, Tanaka A, Maehara T, Ohyama Y, Shimizu M, Nakashima H, Hayashida JN, Shinozaki S, Kubo Y, Furukawa S, Kikuta T, Nakamura S.
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Journal Title
Clin Oral Investig.
Volume: 17(9)
Issue: 9
Pages: 1995-2002
DOI
Related Report
Peer Reviewed
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