Strategic approach for oral cancers based on both of imaging and molecular biologic sides

• Project/Area Number: 24592838
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Kyushu Dental College
• Principal Investigator: Morimoto Yasuhiro 九州歯科大学, 歯学部, 教授 (00275447)
• Project Period (FY): 2012-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: MR spectroscopy / 18F-FDG / PET-CT / Dynamic MR sialography / oral cancer / 機能 / 口腔乾燥症 / 口腔がん

Outline of Final Research Achievements

The quantity and rate of choline and citrate on MR spectroscopy could not precisely be visualized because of the rich fat components in the oral and maxillofacial region. 18F-FDG accumulation reflects the extent of dental inflammation such as periodontal- and periapical-inflammations, not dental caries. At the same time, the front intrinsic muscles of the tongue and upper and lower marginal parts of the orbicularis oris muscle were newly demonstrated as 18F-FDG-PET-positive areas in examining the oral and maxillofacial regions. After ND for oral cancers, we should pay attention to the 18F-FDG distributions in neck-related muscles including the non-surgical side as false-positive findings. Moreover, the rate of patients with 18F-FDG-PET-positive areas increased in the trapezius, sternocleidomastoid, and posterior neck muscles of the surgical and/or non-surgical sides according to the extent of ND of cervical lymph nodes.

Research Products

• [Journal Article] Importance of absorbable surgical sutures for the prevention of stitch abscess after surgery in patients with oral squamous cell carcinoma. (2017)
  • Author(s): Yamamoto N
  • Journal Title: Med Oral Patol Oral Cir Bucal Volume: 22
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A spatial association between odontomas and gubernaculum tracts. (2016)
  • Author(s): Oda M, et al.
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Volume: 121 Issue: 1 Pages: 91-95
  • DOI: 10.1016/j.oooo.2015.10.014
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Alterations in 18F-FDG accumulation into neck-related muscles after neck dissection for patients with oral cancers. (2016)
  • Author(s): Kito S, et al.
  • Journal Title: Med Oral Patol Oral Cir Bucal 2016 Volume: 21
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Spatial and Temporal Responses of the Brain to Noxious Thermal Stimuli in Burning Mouth Syndrome. (2016)
  • Author(s): Shinozaki T et al.
  • Journal Title: J Dent Res Volume: 95 Issue: 10 Pages: 1138-1146
  • DOI: 10.1177/0022034516653580
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Characteristics of the gubernaculum tracts in mesiodens and maxillary anterior teeth with delayed eruption on MDCT and CBCT. (2016)
  • Author(s): Oda M
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Volume: 122 Issue: 4 Pages: 511-516
  • DOI: 10.1016/j.oooo.2016.07.006
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The important pitfalls in the diagnosis of cancer in the oral cavity using 18F-FDG-PET-CT in in Horizons in Cancer Research (2015)
  • Author(s): Kito S, Koga H, Oda M, Tanaka T, Kodama M, Habu M, Miyamoto I, Kokuryo S, Yamamoto N, Matsumoto-Takeda S, Yoshiga D, Nishino T, Nishimura S, Yada N, Noriaki K, Matsuo K, Uehara M, Sasaguri M, Konoo T, Yoshioka I, Tominaga K, Morimoto Y.
  • Journal Title: Nova Science Publishers Volume: 6 Pages: 85-96
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Intraoperative detection of viable bone with fluorescence imaging using visually enhanced lesion scope in patients with bisphosphonate-related osteonecrosis of the jaw: clinical and pathological evaluation. (2015)
  • Author(s): Yoshiga D, Sasaguri M, Matsuo K, Kokuryou S, Habu M, Oda M, Kodama M, Tsurushima H, Sakaguchi O, Sakurai T, Tanaka J, Morimoto Y, Yoshioka I, Tominaga K.
  • Journal Title: Osteoporos Int Volume: 26 Issue: 7 Pages: 1997-2006
  • DOI: 10.1007/s00198-015-3096-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Detection and imaging characteristics of the gubernaculums tract in children on cone beam and multi-detector CT. (2015)
  • Author(s): Nishida I, Oda M, Tanaka T, Kito S, Seta Y, Yada N, Fujita Y, Saeki K, Morikawa K, Matsumoto-Takeda S, Wakasugi-Sato N, Habu M, Kodama M, Miyamoto I, Kokuryo S, Nishimura S, Matsuo M, Tominaga K, Yoshioka I, Maki K, Morimoto Y.
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Volume: 120 Issue: 2 Pages: e109-e117
  • DOI: 10.1016/j.oooo.2015.05.001
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Fluorescence-guided bone resection by using Visually Enhanced Lesion Scope in diffuse chronic sclerosingosteomyelitis of the mandible: Clinical and pathological evaluation. (2015)
  • Author(s): Yoshiga D, Sasaguri M, Matsuo K, Yoshida S, Uehara M, Habu M, Haraguchi K, Tanaka T, Morimoto Y, Yoshioka I, Tominaga K.
  • Journal Title: J Clin Exp Dent Volume: 7 Pages: e548-e551
  • DOI: 10.4317/jced.52268
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] エックス線写真の基礎的知識（デジタルシステムを含む）. (2015)
  • Author(s): 森本泰宏，小田昌史.
  • Journal Title: 歯科医療 Volume: 29 Pages: 4-11
• [Journal Article] Diagnosis and prognostic evaluation for xerostomia using dynamic MR sialography. (2014)
  • Author(s): Oda M, Tanaka T, Habu M, Ono K, Kodama M, Kokuryo S, Yamamoto N, Kito S, Wakasugi-Sato N, Matsumoto-Takeda S, Nishimura S, Murakami K, Koga M, Kaneuji T, Yoshiga D, Miyamoto I, Yamashita Y, Seta Y, Awano S, Yoshioka I, Matsuo K, Tominaga K, Ansai T, Inenaga K, Morimoto Y
  • Journal Title: Curr Med Imaging Rev Volume: 10 Pages: 84-94
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] predict the success of local anesthetic block after initial treatment by the carbamazepine? (2014)
  • Author(s): Shiiba S, Tanaka T, Sakamoto E, Oda M, Kito S, Ono K, Wakasugi-Sato N, Matsumoto-Takeda S, Seta Y, Imamura Y, Nakanishi O, Inenaga K, Morimoto Y
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Volume: 117 Issue: 1 Pages: 15-21
  • DOI: 10.1016/j.oooo.2012.03.029
  • Peer Reviewed / Open Access
• [Journal Article] The significance of cone beam computed tomography for the visualization of anatomical variations and lesions in the maxillary sinus for patients hoping to have dental implant-supported maxillary restorations in a private dental office in Japan (2014)
  • Author(s): Shiki K, Tanaka T, Kito S, Wakasugi-Sato N, Matsumoto-Takeda S, Oda M, Nishimura S, Morimoto Y
  • Journal Title: Head Face Med Volume: 10 Issue: 1 Pages: 20-20
  • DOI: 10.1186/1746-160x-10-20
  • Peer Reviewed / Open Access
• [Journal Article] New approach for functional evaluation of swallowing by visualizing saline flow using high-speed continuous MRI based on T2-weighted sequences (2014)
  • Author(s): Tanaka T, Oda M, Nishimura S, Kito S, Wakasugi-Sato N, Kodama M, Kokuryo S, Habu M, Miyamoto I, Yamashita Y, Aso A, Sadasue K, Nagashima R, Tominaga K, Yoshioka I, Morimoto Y
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Volume: 118 Issue: 4 Pages: 490-496
  • DOI: 10.1016/j.oooo.2014.05.014
  • Peer Reviewed
• [Journal Article] Identification and adjustment of experimental occlusal interference using functional magnetic resonance imaging. (2014)
  • Author(s): Oda M, Yoshino K, Tanaka T, Shiiba S, Makihara E, Miyamoto I, Nogami S, Kito S, Wakasugi-Sato N, Matsumoto-Takeda S, Nishimura S, Murakami K, Koga M, Kawagishi S, Yoshioka I, Masumi S, Kimura M, Morimoto Y.
  • Journal Title: BMC Oral Health Volume: 14 Issue: 1 Pages: 124-124
  • DOI: 10.1186/1472-6831-14-124
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Occurrence of silk stitch abscess after surgery in patients with oral squamous cell carcinoma (2013)
  • Author(s): Yamamoto N, Yamashita Y, Yoshiga D, Ishikawa A, Matsuo K, Miyamoto I, Oda M, Tanaka T, Kito S, Seta Y, Takahashi T, Koga H, Kenji K, Morimoto Y
  • Journal Title: Med Oral Patol Oral Cir Bucal Volume: 18 Pages: e701-e705
  • DOI: 10.4317/medoral.18792
  • Peer Reviewed
• [Journal Article] Variety and complexity of fluorine-18-labelled-fluoro-2-deoxy-D-glucose accumulations in the oral cavity of patients with oral cancers. (2013)
  • Author(s): Kito S
  • Journal Title: Dentomaxillofac Radiol. Volume: 42 Issue: 7 Pages: 1-8
  • DOI: 10.1259/dmfr.20130014
  • Peer Reviewed
• [Journal Article] Identification of peripheral vessels in oral and maxillofacial regions on magnetic resonance angiography obtained using a balanced steady-state free-precession sequence with a time-spatial labeling inversion pulse and using fresh blood imaging (2013)
  • Author(s): Oda M, Tanaka T, Yamashita Y, Kito S, Wakasugi-Sato N, Matsumoto-Takeda S, Nishimura S, Habu M, Kodama M, Uehara M, Kaneuji T, Kokuryo S, Miyamoto I, Yoshiga D, Seta Y, Tominaga K, Yoshioka I, Morimoto Y
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Volume: 219 Issue: 6 Pages: 791-7
  • DOI: 10.1016/j.oooo.2013.09.016
  • Peer Reviewed
• [Journal Article] Magnetic resonance angiography with fresh blood imaging for identification of hemangiomas and blood vessels around hemangiomas in oral and maxillofacial regions. (2012)
  • Author(s): Oda M. et al
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Volume: 113 Issue: 4 Pages: 559-566
  • DOI: 10.1016/j.oooo.2011.10.003
  • Peer Reviewed
• [Journal Article] Effect of bone quality and position of the inferior alveolar nerve canal in continuous, long-term, neurosensory disturbance after sagittal split ramus osteotomy. (2012)
  • Author(s): Yoshioka I et al.
  • Journal Title: J Craniomaxillofac Surg Volume: 40 Issue: 6 Pages: e178-e183
  • DOI: 10.1016/j.jcms.2011.09.003
  • Peer Reviewed
• [Journal Article] Reflection of 18F-FDG accumulation in the evaluation of the extent of periapical or periodontal inflammation. (2012)
  • Author(s): Kito S, Kitamura C, Morimoto Y, et al.
  • Journal Title: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology Volume: 114(6): Issue: 6 Pages: 62-69
  • DOI: 10.1016/j.oooo.2012.05.027
  • Peer Reviewed
• [Presentation] Functional MRIを用いた咬合状態の評価に関する研究. (2016)
  • Author(s): 森本泰宏ら
  • Organizer: 第16回日本外傷歯学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2016-07-17
• [Presentation] MR cisternographyやCTによる三叉神経痛の評価と予後予測. (2016)
  • Author(s): 森本泰宏
  • Organizer: 第70回 日本口腔科学会総会・学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2016-04-17
  • Invited
• [Presentation] 教育研修会 初学者のための画像検査の進め方. (2015)
  • Author(s): 森本泰宏
  • Organizer: 第20回 日本歯科放射線学会臨床画像大会.
  • Place of Presentation: 福岡
  • Year and Date: 2015-10-25
  • Invited
• [Presentation] パノラマエックス線画像による口蓋扁桃結石の検出に関する臨床的研究. (2015)
  • Author(s): 森本泰宏，小田昌史.
  • Organizer: 第26回西日本臨床小児口腔外科学会総会.
  • Place of Presentation: 別府
  • Year and Date: 2015-10-04
• [Presentation] 九州歯科大学附属病院歯科放射線科・放射線部における画像検査の変遷 ―過去と現在の比較―. (2015)
  • Author(s): 森本泰宏，松本 忍，鬼頭慎司，田中達朗，小田昌史，西村 瞬.
  • Organizer: 第28回日本口腔診断学会総会.
  • Place of Presentation: 東京
  • Year and Date: 2015-09-05
• [Presentation] 歯科用コーンビームCTの歯科疾患への応用 ―歯と歯周組織病変を中心に―. (2015)
  • Author(s): 森本泰宏，小田昌史，鬼頭慎司，松本 忍，西村 瞬，田中達朗，福島直樹，辻 裕文，有住隆史，曽我富美雄，楠崎晴規.
  • Organizer: 第15回日本外傷歯学会総会.
  • Place of Presentation: 北九州
  • Year and Date: 2015-07-11
• [Presentation] 歯科用コーンビームCTの臨床応用における基本的考え. (2015)
  • Author(s): 森本泰宏，北村知昭，佐伯 桂，正木千尋，宮本郁也，小田昌史，青木隆憲，諸冨孝彦，牧 憲司，細川隆司，吉岡 泉，冨永和宏.
  • Organizer: 第75回九州歯科学会総会.
  • Place of Presentation: 北九州
  • Year and Date: 2015-05-23
• [Presentation] 九州歯科大学附属病院歯科放射線科における画像検査件数の推移. (2014)
  • Author(s): 森本泰宏，松本 忍，鬼頭慎司，田中達朗，小田昌史，若杉奈緒，西村 瞬，古賀正浩，村上慶太，岩脇 梢，内田朱美，廣松辰巳，志岐一欣.
  • Organizer: 日本歯科放射線学会第34回関西・九州合同地方会
  • Place of Presentation: 長崎
  • Year and Date: 2014-12-06
• [Presentation] 小児の顎骨病変における画像診断. (2014)
  • Author(s): 森本泰宏
  • Organizer: 第25回 西日本臨床小児口腔外科学会総会・学術大会
  • Place of Presentation: 北九州
  • Year and Date: 2014-09-27
  • Invited
• [Presentation] 口腔・顎・顔面領域におけるPETによる機能診断. (2014)
  • Author(s): 森本泰宏
  • Organizer: 第14回日本外傷歯学会総会・学術大会
  • Place of Presentation: 大阪
  • Year and Date: 2014-07-26
  • Invited
• [Presentation] 口腔・顎・顔面領域における画像診断と臨床研究. (2014)
  • Author(s): 森本泰宏
  • Organizer: 第55回 日本歯科放射線学会総会・学術大会
  • Place of Presentation: 東京
  • Year and Date: 2014-06-07
  • Invited
• [Presentation] 根尖性及び成人性歯周炎による骨消失と18F-FDG集積との関係について. (2014)
  • Author(s): 森本泰宏，吉岡 泉，冨永和宏
  • Organizer: 第68回 日本口腔科学会総会・学術大会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-08
• [Presentation] 口腔領域における画像を用いた臨床研究 (2013)
  • Author(s): 森本泰宏
  • Organizer: 第67回 日本口腔科学会総会
  • Place of Presentation: 栃木
  • Invited
• [Presentation] 歯根未完成歯を用いて長期生着に成功した歯牙移植の2症例. (2013)
  • Author(s): 森本泰宏，辻 裕文, 志岐一欣，志岐一欣，有住隆史，曽我富美雄，楠崎晴規, 若杉（佐藤）奈緒，鬼頭慎司
  • Organizer: 第24回西日本臨床小児口腔外科学会総会
  • Place of Presentation: 島根大学医学部
• [Presentation] コーンビームCTを用いた歯科疾患に対する画像診断.
  • Author(s): 森本泰宏
  • Organizer: 第2回 日本外傷歯学会西日本地方会
  • Place of Presentation: 北九州市
  • Invited
• [Presentation] 口腔外傷治療最前線 口腔・顎骨部の外傷に対する画像検査と被ばくについて
  • Author(s): 森本泰宏
  • Organizer: 第22回 日本歯科医学会総会
  • Place of Presentation: 大阪
  • Invited
• [Book] 今さら聞けない歯科用CBCTとCTの読像法－三次元でみる顎顔面領域の正常画像解剖と疾患－ (2017)
  • Author(s): 森本泰宏
  • Total Pages: 114
  • Publisher: クインテッセンス出版
• [Book] 新歯科放射線学 第2版 (2017)
  • Author(s): 森本泰宏
  • Total Pages: 382
  • Publisher: 医学情報社
• [Book] Cased Based Review 画像診断に強くなる 顎口領域の疾患 読影ポイントから病理診断、治療方針まで (2017)
  • Author(s): 森本泰宏
  • Total Pages: 296
  • Publisher: 永末書店
• [Book] 乳歯列期における外傷歯の診断と治療 第2版 (2013)
  • Author(s): 森本泰宏
  • Total Pages: 124
  • Publisher: クインテッセンス出版
• [Book] 歯科放射線学 第5版 (2013)
  • Author(s): 森本泰宏
  • Total Pages: 456
  • Publisher: 医歯薬出版
• [Book] 一歩先のパノラマ診断力 (2012)
  • Author(s): 金田 隆 編集
  • Total Pages: 160
  • Publisher: 砂書房
• [Book] The suggestion for standard scanning procedures of ultrasonographic examinations when surveying cervical lymph nodes in patients with oral squamous cell carcinoma (2012)
  • Author(s): Wakasugi-Sato N et al.
  • Total Pages: 100
  • Publisher: Nova Science Publishers