The accumulation mechanisms of F18 - choline as a PET tracer and clinical development
| Project/Area Number |
24592840
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TERASAKI Kazunori 岩手医科大学, 医学部, 講師 (60285632)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | PET / FDG / choline / oral cancer / pet / fdg / Choline / 口腔癌 / 放射線性骨髄炎 / 顎骨浸潤 / SUV |
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| Outline of Final Research Achievements |
We showed a significantly higher 18F-FDG uptake in gingival cancer with jaw bone invasion than in tongue cancer, and clarified the characteristics of 18F-FDG uptake in comparison with 18F or 11C - choline uptake. PET with 18F-FDG showed a higher SUV in gingival cancer with jaw bone invasion than tongue cancer. There are 2 possible explanations for this finding. One is the binding of 18F itself to hydroxyapatite. The other is 18F-FDG accumulation in bone metabolism-associated cells. However, despite 18F-choline uptake being comparable to 18F-FDG uptake in tongue cancer, 18F-choline uptake was similar between tongue cancer and gingival cancer with jaw bone metastasis. Therefore, the binding of 18F itself to hydroxyapatite may be slight. These results suggest that 18F-FDG, unlike 18F-choline, accumulates in not only tumor cells but also inflammation-associated cells and bone metabolism-associated cells such as osteoblasts and osteoclasts, resulting in an apparently high SUV.
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Report
(4 results)
Research Products
(15 results)
