Role of inflammation in the initiation and development of oral squamous cell carcinoma
| Project/Area Number |
24592841
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TAKADA Eiko 東京医科大学, 医学部, 講師 (50110903)
SATOMI Takafumi 東京医科大学, 医学部, 准教授 (70276921)
YANASE Noriko 東京医科大学, 医学部, 講師 (10210303)
HATA Kikumi 東京医科大学, 医学部, 講師 (30287156)
TOYOTA Hiroko 東京医科大学, 医学部, 助手 (80468660)
FURUHATA Masae 東京医科大学, 医学部, 助手 (90468661)
KATAHIRA Takashi 東京医科大学, 医学部, ポストドクター (20626642)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 扁平上皮癌 / 炎症 / 転移 / 癌幹細胞 / 口腔扁平上皮癌 |
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| Outline of Final Research Achievements |
Metastasis of tumor cells into lung was increased in mice with bronchial inflammation compared with control mice, while the lung metastasis was severely reduced in IL-10-deficient mice with bronchial inflammation. The cellular and molecular mechanisms underlying these events involve inflammatory responses, antibody responses, and interaction of chemokine and chemokine receptors. Next, we enriched cancer stem cells (CSCs) from the squamous cell carcinoma cell lines using a sphere-forming assay and cell surface markers, and have demonstrated that Akt played a crucial role in the function and maintenance of CSCs. Furthermore, we demonstrated that tumor growth was prevented by preadministration of modified tumor antigen and cytokine. Thus, these findings might be important for understanding of regulation of tumor growth and metastasis.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Requirement of apoptosis-inducing kinase 1 for the induction of bronchial asthma following stimulation with ovalbumin.2013
Author(s)
Takada, E., Furuhata, M., Nakae, S., Ichijo, H., Sudo, K. and Mizuguchi, J.
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Journal Title
Int. Arch. Allergy Immunol.
Volume: 162
Issue: 2
Pages: 104-114
DOI
Related Report
Peer Reviewed
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