| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus that usually results in latent infection of B cells. Interestingly, increasing evidence has accumulated over the past 10 years supporting a role for EBV as a pathogenic agent of periodontal disease because bacterial activities alone do not explain several of its clinical characteristics. We established for the first time, more EBV DNA is found deeper in periodontal pockets of chronic periodontitis in Japanese patients. Interestingly, the odds of acquiring chronic periodontitis were higher in the presence of both EBV DNA and P. gingivalis compared with either EBV DNA or P. gingivalis only. In addition, we found that P. gingivalis induced EBV reactivation and EBV stimulated production of inflammatory cytokines. Although additional basic and clinical studies are needed, our findings would suggest a relationship between periodontal disease and EBV reactivation.
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