| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Outline of Final Research Achievements |
Recentrly, numerous studies have been demonstrated that the involvement between the progression of atherosclerosis and oral infection by periodontal pathogens. It has been reported that periodontal pathogen-induced atherosclerosis may be regulated by direct (endothelial cell may be infected by periodontal pathogen), and indirect (development of atheromatous plaque may be attributed to endotoxin from periodontal pathogens) mechanisms. In this study, to analyze the direct role of periodontal pathogen to progress of atherosclerosis, we produced green fluorescent protein-expressing Aggregatibacter actinomycetemcomitans, which is one of the major periodontal pathogen, under the control of luekotoxin promotor for minitoring of A. actinomycetemcomitans after oral infection.
|
