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Risk estimation of osteoporotic fracture and atherosclerosis by oral health indices on panoramic radiographs

Research Project

Project/Area Number 24592849
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionMatsumoto Dental University

Principal Investigator

TAGUCHI Akira  松本歯科大学, 歯学部, 教授 (70243582)

Co-Investigator(Kenkyū-buntansha) YOSHINARI Nobuo  松本歯科大学, 歯学部, 教授 (20231699)
HIGASHI Yukihito  広島大学, 原爆放射線医科学研究所, 教授 (40346490)
細井 孝之  独立行政法人国立長寿医療研究センター, その他部局等, その他 (40240709)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords骨粗鬆症 / 動脈硬化 / パノラマエックス線写真 / 骨折 / 顎骨 / スクリーニング / パノラマX線写真 / 総頚動脈石灰化所見 / パノラマX線写真 / オッズ比 / 大腿骨 / 頚部石灰化
Outline of Final Research Achievements

One thousand twenty-one subjects aged 40 to 89 years old, participated in this study. Eighty-eight patients received a diagnosis of osteoporosis, and 55 were diagnosed with osteoporotic fractures. We classified the shape of the mandibular cortex on panoramic radiographs as normal, moderately eroded, or severely eroded. Also we determined the presence of carotid artery calcification (CAC) on panoramic radiographs. The odds ratios for an osteoporosis diagnosis associated with moderately eroded and severely eroded mandibular cortices were 1.4 (95% CI, 0.8 to 2.6) and 2.6 (95% CI, 1.4 to 5.0), respectively. That associated with the presence of CAC was 1.8 (95% CI, 1.0 to 3.2). However, the odds ratios for an osteoporotic fracture associated with eroded cortices and CAC did not become higher (not significant).
Subjects in Japan with eroded mandibular cortices and CAC tended to be at increased risk for osteoporosis diagnoses but not for fractures.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (53 results)

All 2015 2014 2013 2012 Other

All Journal Article (20 results) (of which Peer Reviewed: 20 results,  Open Access: 3 results,  Acknowledgement Compliant: 6 results) Presentation (28 results) (of which Invited: 14 results) Book (5 results)

  • [Journal Article] Panoramic radiography measurements, osteoporosis diagnoses, and fractures in Japanese men and women2015

    • Author(s)
      Yamada S, Uchida K, Iwamoto Y, Sugino N, Yoshinari N, Kagami H, Taguchi A
    • Journal Title

      Oral Diseases

      Volume: 21 Issue: 3 Pages: 335-341

    • DOI

      10.1111/odi.12282

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Diagnosis and Management of Osteonecrosis of the Jaw: A Systematic Review and International Consensus2015

    • Author(s)
      Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O’Ryan F, Reid IR, Ruggiero S, Taguchi A, et al.
    • Journal Title

      Journal of Bone and Mineral Research

      Volume: 30 Issue: 1 Pages: 3-23

    • DOI

      10.1002/jbmr.2405

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Association of cortical shape of the mandible on panoramic radiographs with mandibular trabecular bone structure in Japanese adults - cone beam CT image analysis2014

    • Author(s)
      Mochizuki N, Sugino N, Ninomiya T, Yoshinari N, Udagawa N, Taguchi A
    • Journal Title

      Oral Radiology

      Volume: 30 Issue: 2 Pages: 160-167

    • DOI

      10.1007/s11282-013-0155-z

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Poor oral health behavior, decreased frequency of tooth brushing, is associated with endothelial dysfunction2014

    • Author(s)
      Kajikawa M, Nakashima A, Maruhashi T, Iwamoto Y, Iwamoto A, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Goto C, Taguchi A, Noma K, Higashi Y
    • Journal Title

      Circulation Journal

      Volume: 78 Pages: 950-954

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] パノラマエックス線画像上の下顎骨下縁皮質骨内面の線状の骨吸収像を用いた骨粗鬆症診断支援システムの関心領域選択の自動化2014

    • Author(s)
      中元 崇,田口 明,浅野 晃,谷本啓二
    • Journal Title

      歯科放射線

      Volume: 54 Pages: 15-21

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Clinical significance of carotid artery calcification seen on panoramic radiographs2014

    • Author(s)
      Uchida K, Sugino N, Yamada S, Kuroiwa H, Yoshinari N, Asano A, Taguchi A,Muneyasu M
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 23 Pages: 461-466

    • NAID

      130004700433

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Poor oral health behavior, decreased frequency of tooth brushing, is associated with endothelial dysfunction.2014

    • Author(s)
      Kajikawa M, Nakashima A, Maruhashi T, Iwamoto Y, Iwamoto A, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Goto C, Taguchi A, Noma K, Higashi Y
    • Journal Title

      Circ J

      Volume: 25 Pages: 950-954

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Recognition of bisphosphonate-related osteonecrosis of the jaws among oral and maxillofacial radiologists: Results from the questionnaire-based survey in Japan.2013

    • Author(s)
      Taguchi A, Akiyama H, Koseki T, Shimizutani K.
    • Journal Title

      Oral Radiol

      Volume: 29 Pages: 98-104

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between oral health and the risk of lacunar infarction in Japanese adults.2013

    • Author(s)
      Taguchi A, Miki M, Muto A, Kubokawa K, Migita K, Higashi Y, Yoshinari N.
    • Journal Title

      Gerontology

      Volume: 59 Issue: 6 Pages: 499-506

    • DOI

      10.1159/000353707

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of carotid artery calcification detected on dental panoramic radiographs with a history of osteoporosis diagnosis without prevalent fractures.2013

    • Author(s)
      Taguchi A, Iwamoto Y, Yamada S, Sugino N, Kuroiwa H, Uchida K, Higashi Y
    • Journal Title

      J Radiol Radiat Ther

      Volume: 1 Pages: 1020-1020

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of open mouth and rubber dam on upper airway patency and breathing.2013

    • Author(s)
      Iwatani K, Matsuo K, Kawase S, Wakimoto N, Taguchi A, Ogasawara T
    • Journal Title

      Clin Oral Investig

      Volume: 17 Issue: 5 Pages: 1295-1299

    • DOI

      10.1007/s00784-012-0810-5

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Morphological changes in the temporomandibular joint before and after sagittal splitting ramus osteotomy of the mandible for skeletal mandibular protrusion.2013

    • Author(s)
      Enami K, Yamada K, Kageyama T, Taguchi A
    • Journal Title

      Cranio

      Volume: 31 Pages: 123-132

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Combination of histogram-based automatic clustering algorithm and support vector machine for the diagnosis of osteoporosis.2013

    • Author(s)
      Kavitha MS, Asano A, Taguchi A, Heo MS
    • Journal Title

      Imaging Sci Dent

      Volume: 43 Issue: 3 Pages: 153-161

    • DOI

      10.5624/isd.2013.43.3.153

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intramusclar changes of soft and hard areas after low-level static contraction of the masseter muscle and the correlations with muscle hardness and increase in water content: Evaluations with sonographic elastography and magnetic resonance imaging2013

    • Author(s)
      Ariji Y,Nakayama M,Taguchi A,Gotoh A,Kise Y,Katsumata A,Kurita K,Ariji E
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol

      Volume: 116(3) Issue: 3 Pages: 354-361

    • DOI

      10.1016/j.oooo.2013.05.017

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Recognition of bisphosphonate-related osteonecrosis of the jaw among oral and maxillofacial radiologists: results from a questionnaire-based survey in Japan2013

    • Author(s)
      Taguchi A, Akiyama H, Koseki T, Shimizutani K
    • Journal Title

      Oral Radiol

      Volume: in press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Osteoprotegerin-deficient male mice as a model for severe alveolar bone loss: Comparison with RANKL-overexpressing transgenic male mice.2013

    • Author(s)
      Koide M et al.
    • Journal Title

      Endocrinology

      Volume: 190 Issue: 2 Pages: 773-782

    • DOI

      10.1210/en.2012-1928

    • Related Report
      2012 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of open mouth and rubber dam on upper airway patency and breathing2013

    • Author(s)
      Iwatani K, Matsuo K, Kawase S, Wakimoto N, Taguchi A, Ogasawara T
    • Journal Title

      Clin Oral Investig

      Volume: in press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Endothelial dysfunction and hypertension in aging.2012

    • Author(s)
      Higashi Y, Kihara Y, Noma K
    • Journal Title

      Hypertens Res

      Volume: 35 Issue: 11 Pages: 1039-47

    • DOI

      10.1038/hr.2012.138

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of CYP19 gene polymorphism with vertebral fractures in Japanese postmenopausal women2012

    • Author(s)
      Koudu Y, Onouchi T, Hosoi T, Horiuchi T
    • Journal Title

      Biochem Genet

      Volume: 50 Pages: 589-596

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intima-Media Thickness of Brachial Artery, Vascular Function, and Cardiovascular Risk Factors.2012

    • Author(s)
      Iwamoto Y, Maruhash T, Fujii Y, Idei N, Fujimura N, Mikami S, Kajikawa M, Matsumoto T, Kihara Y, Chayama K, Noma K, Nakashima A, Higashi Y.
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 32 Issue: 9 Pages: 2295-2303

    • DOI

      10.1161/atvbaha.112.249680

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] パノラマエックス線写真による骨粗鬆症スクリーニング、国際顎骨壊死コンセンサスおよびコーンビームCT2014

    • Author(s)
      田口 明
    • Organizer
      玖珂歯科医師会学術講演会
    • Place of Presentation
      山口県岩国市油政会議室(岩国市)
    • Year and Date
      2014-11-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 歯科用パノラマエックス線写真の骨粗鬆症スクリーニング指標と現在歯数との関連2014

    • Author(s)
      田口 明,杉野紀幸,岩本弥恵,山田真一郎,内田啓一
    • Organizer
      第16回日本骨粗鬆症学会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2014-10-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Diagnostic performance for identifying osteoporotic postmenopausal women without prevalent fractures by dental panoramic radiographs2014

    • Author(s)
      Taguchi A, Sugino N, Yamada S, Iwamoto Y, Uchida K, Kamimura M
    • Organizer
      American Society for Bone and Mineral Research Annual Meeting
    • Place of Presentation
      The George R. Brown Convention Center, Houston, Texas, USA
    • Year and Date
      2014-09-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] 顎骨と全身-画像診断医の立場から2014

    • Author(s)
      田口 明
    • Organizer
      兵庫県保険医協会
    • Place of Presentation
      兵庫県保険医協会5階会議室(神戸市)
    • Year and Date
      2014-08-31
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 歯科用パノラマエックス線写真による骨粗鬆症スクリーニング2014

    • Author(s)
      田口 明
    • Organizer
      第23回日本骨代謝学会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2014-07-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 歯科放射線学による予防医学の推進―骨粗鬆症スクリーニング法の開発と展望2014

    • Author(s)
      田口 明
    • Organizer
      第5回骨バイオサイエンス研究会
    • Place of Presentation
      地域医療人育成センター おかやまMUSCAT CUBE(岡山市)
    • Year and Date
      2014-06-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 口腔衛生指標によるFRAXの10年間骨折リスクの推定に関する検討2014

    • Author(s)
      田口 明,三木 学,武藤昭紀,窪川恵太,海瀬聖仁,内田啓一,吉成伸夫
    • Organizer
      第57回春季日本歯周病学会学術大会
    • Place of Presentation
      長良川国際会議場(岐阜市)
    • Year and Date
      2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] パノラマエックス線写真を用いた骨粗鬆症スクリーニング2014

    • Author(s)
      田口 明
    • Organizer
      長野県歯科医療管理学会
    • Place of Presentation
      上伊那歯科医師会館(伊那市)
    • Year and Date
      2014-05-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Diagnostic performances of panoramic radiography measures in identifying post-menopausal women with a high risk of fractures.

    • Author(s)
      Taguchi A, Nakamoto T, Ohtsuka M, Tanimoto K, Sanada M
    • Organizer
      The 19th International Congress of Dentomaxillofacial Radiology
    • Place of Presentation
      Grieghallen - International Congress and Exhibition Centre, Bergen, Norway
    • Related Report
      2013 Research-status Report
  • [Presentation] Association of clinical and panoramic radiography measures with ten year probability of fracture.

    • Author(s)
      Taguchi A, Miki M, Kubokawa K, Muto A, Hosoi T, Yoshinari N
    • Organizer
      The 19th International Congress of Dentomaxillofacial Radiology
    • Place of Presentation
      Grieghallen - International Congress and Exhibition Centre, Bergen, Norway
    • Related Report
      2013 Research-status Report
  • [Presentation] パノラマX線写真による総頚動脈の石灰化所見と骨粗鬆症との関係.

    • Author(s)
      田口 明,山田真一郎,岩本弥恵,望月慎恭,長内 秀,杉野紀幸,黒岩博子,藤木知一,内田啓一
    • Organizer
      日本歯科放射線学会・第217回関東地方会・第33回北日本地方会・第21回合同地方会
    • Place of Presentation
      新潟大学、新潟市
    • Related Report
      2013 Research-status Report
  • [Presentation] ビスフォスフォネート製剤関連顎骨骨髄炎・顎骨壊死の現状と対応-医科歯科連携における口腔管理とリハビリテーションの重要性.

    • Author(s)
      田口 明
    • Organizer
      鳥取県臨床整形外科医会学術講演会
    • Place of Presentation
      ホテルサンルート米子、米子市
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] ビスフォスフォネート製剤関連顎骨骨髄炎・顎骨壊死への対応-国際顎骨壊死ガイドラインを含めて.

    • Author(s)
      田口 明
    • Organizer
      長崎県央オステオポロシスセミナー
    • Place of Presentation
      ホテルグランドパレス諫早、諫早市
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] パノラマX線写真による総頚動脈の石灰化所見と骨粗鬆症診断歴との関係.

    • Author(s)
      田口 明,岩本弥恵,山田真一郎,杉野紀幸,内田啓一
    • Organizer
      第15回日本骨粗鬆症学会
    • Place of Presentation
      大阪国際会議場、大阪市
    • Related Report
      2013 Research-status Report
  • [Presentation] 骨吸収抑制剤関連顎骨骨髄炎・顎骨壊死-国際顎骨壊死コンセンサスを含めて.

    • Author(s)
      田口 明
    • Organizer
      Breast Cancer Bone Management Forum
    • Place of Presentation
      ANAクラウンプラザホテル新潟、新潟市
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 自己申告の身長低下および腰の曲がりと喪失歯数との関係.

    • Author(s)
      田口 明,杉野紀幸,上村幹男
    • Organizer
      第15回日本骨粗鬆症学会
    • Place of Presentation
      大阪国際会議場、大阪市
    • Related Report
      2013 Research-status Report
  • [Presentation] パノラマエックス線写真の骨粗鬆症スクリーニング指標とFRAXⓇによる十年骨折リスクとの関係.

    • Author(s)
      田口 明,三木 学,杉野紀幸,吉成伸夫,内田啓一,細井孝之
    • Organizer
      日本歯科放射線学会第218回関東地方会
    • Place of Presentation
      東京医科歯科大学、東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 骨粗鬆症の画像診断:「顎骨の骨粗鬆症」

    • Author(s)
      田口 明
    • Organizer
      第33回日本画像医学会
    • Place of Presentation
      東京ステーションコンファレンス、東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] パノラマX線写真によるラクナ梗塞のスクリーニング-骨粗鬆症及び梗塞性心臓血管病変と比較して

    • Author(s)
      田口 明
    • Organizer
      特定非営利活動法人日本歯科放射線学会2012年度総会(第53回)
    • Place of Presentation
      岩手県民情報交流センター(盛岡市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 現在歯数は過去の骨の関連指標と関係を有するか

    • Author(s)
      田口 明
    • Organizer
      一般社団法人日本女性医学学会2012年度総会(第27回)
    • Place of Presentation
      山形国際ホテル(山形市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 難治性骨髄炎の画像診断~予兆像を探る~

    • Author(s)
      田口 明
    • Organizer
      特定非営利活動法人日本歯科放射線学会第17回臨床画像大会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] BRONJの画像所見と鑑別診断

    • Author(s)
      田口 明
    • Organizer
      第57回(社)日本口腔外科学会総会・学術大会口腔3学会合同シンポジウム
    • Place of Presentation
      パシフィコ横浜会議センター(横浜市)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] BRONJ in Japan

    • Author(s)
      Taguchi A
    • Organizer
      The 13th Korean Society of Osteoporosis Meeting
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 歯科放射線学による予防医学の推進―骨粗鬆症、動脈硬化と乳癌スクリーニングへの展望

    • Author(s)
      田口 明
    • Organizer
      栃木県歯科医学会
    • Place of Presentation
      栃木県歯科医師会館(宇都宮市)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] パノラマ X 線写真による骨粗鬆症スクリーニング法開発と動脈硬化、 乳癌スクリーニングへの展望

    • Author(s)
      田口 明
    • Organizer
      第15回日本歯科人間ドッグ学会総会・学術大会
    • Place of Presentation
      鶴見大学会館(横浜市)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Number of teeth remaining and past bone-related markers

    • Author(s)
      Taguchi A
    • Organizer
      IADR/AADR/CADR 90th General Session and Exhibition
    • Place of Presentation
      Seattle, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Diagnostic performances of panoramic radiography measures in identifying post-menopausal women with a high risk of fractures

    • Author(s)
      Taguchi A
    • Organizer
      The 19th International Congress of Dentomaxillofacial Radiology
    • Place of Presentation
      Bergen, Norway
    • Related Report
      2012 Research-status Report
  • [Presentation] Association of clinical and panoramic radiography measures with ten year probability of fracture

    • Author(s)
      Taguchi A
    • Organizer
      The 19th International Congress of Dentomaxillofacial Radiology
    • Place of Presentation
      Bergen, Norway
    • Related Report
      2012 Research-status Report
  • [Book] ビスホスホネートエビデンスブック2013

    • Author(s)
      田口 明
    • Total Pages
      383
    • Publisher
      医薬ジャーナル
    • Related Report
      2013 Research-status Report
  • [Book] 歯科放射線学-第5版-(分担)2013

    • Author(s)
      田口 明
    • Publisher
      医歯薬出版
    • Related Report
      2012 Research-status Report
  • [Book] 基礎から始める歯科放射線学2012

    • Author(s)
      田口 明
    • Total Pages
      378
    • Publisher
      株式会社IDP出版
    • Related Report
      2012 Research-status Report
  • [Book] パノラマX線写真による骨粗鬆症スクリーニング法 - Teeth Tell Tales on Bones -2012

    • Author(s)
      田口 明
    • Total Pages
      153
    • Publisher
      株式会社IDP出版
    • Related Report
      2012 Research-status Report
  • [Book] 一歩先のパノラマ診断力(分担)2012

    • Author(s)
      田口 明
    • Total Pages
      156
    • Publisher
      砂書房
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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