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Creating a diagnostic antibody and the search of the genes that define the pre-cancerous lesions of the oral cavity: from rats to humans

Research Project

Project/Area Number 24592850
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionAsahi University

Principal Investigator

TANUMA Junichi  朝日大学, 歯学部, 教授 (20305139)

Co-Investigator(Kenkyū-buntansha) MOTOHIKO Nagayama  朝日大学, 歯学部, 准教授 (50298436)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords舌癌 / 発がん / 前癌病変 / 診断基準 / 上皮異形成 / モデル動物 / 境界病変 / 前癌病変マーカー / 抗体作成 / hnRNPK / 腫瘍マーカー
Outline of Final Research Achievements

Tongue cancer is to clarify the correlation between the gene mutation and tissue type in pre-cancerous lesions and borderline lesions of (oral cancer), and have found a new marker, which is an indicator of the diagnostic criteria and prognosis of pathological tissue diagnosis, epithelial dysplasia and epithelial lesion such as squamous cell carcinoma, we have established the objective diagnostic criteria of everyday struggling to cases.
According to tongue cancer model animal, we were able to the selection and establishment and functional analysis of genes that before defining the cancer lesion.To complete the antibody of the tumor marker of evaluation and serum in the pathological tissue of human precancerous lesions. A pre-cancerous lesion marker of establishment can be oral could be applied to immunostaining for cytology.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (39 results)

All 2015 2014 2013 2012 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results,  Open Access: 5 results,  Acknowledgement Compliant: 5 results) Presentation (23 results) (of which Invited: 11 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Establishment of a novel dwarf rat strain: cartilage calcification insufficient (CCI) rats.2015

    • Author(s)
      Tanaka M, Minoru Watanabe M, Yokomi I, Matsumoto N, Sudo K, Satoh H, Igarashi T, Seki A, Amano H, Ohura K, Kakei R, Shibata S, Nagayama M, Tanuma J.
    • Journal Title

      Experimental Animals

      Volume: 64 Pages: 1-25

    • NAID

      130005069857

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hypomineralized Enamel of Dens Invaginatus. Its distinct images and pathogenesis of the Type III invagination using micro-focusing computed tomography.2014

    • Author(s)
      Yamada M, Nagayama M, Katsumata A, Kawano S, Gen K, Ehara M, Nakao J, Tanuma J, Yoshida T
    • Journal Title

      J Hard Tissue Biology

      Volume: 23(4) Pages: 449-453

    • NAID

      130004700431

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 顎嚢胞が疑われた上顎洞粘液嚢胞の1例2014

    • Author(s)
      松原 誠、式守道夫、村木智則、川原田幸司、諏訪裕彦、庵原明倫、長縄鋼亮、江原道子、永山元彦、田沼順一、住友伸一郎.
    • Journal Title

      岐阜歯科学会雑誌

      Volume: 40(3) Pages: 264-267

    • NAID

      120005867903

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Epithelial-mesenchymal transition in oral squamou s cell carcinoma of the gingiva: An immunohistochemical and ultrastructual case study.2014

    • Author(s)
      Ihara A, Nagayama M, Matsubara M, Kawarada K, Suwa H, Ehara M, Skimori M, Tanuma J.
    • Journal Title

      J. Gifu Dent. Soc

      Volume: 40(3) Pages: 258-263

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pthlh, a promising cancer modifier gene in rat tongue carcinogenesis.2014

    • Author(s)
      Suwa H, Hirano M, Kawarada K, Nagayam M, Ehara M, Muraki T, Shisa H, Sugiyama A, Sugimoto M, Hiai H, Kitano M, Tanuma J.
    • Journal Title

      Oncology Reports

      Volume: 31 Pages: 3-12

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 口蓋粘膜に生じた悪性黒色腫の1例2013

    • Author(s)
      長縄鋼亮、住友伸一郎、太田貴久、祭豪倫、山田和人、永山元彦、田沼順一、赤井崇浩、 稲垣俊弘、式守道夫.
    • Journal Title

      岐阜歯科学会雑誌

      Volume: 40(1) Pages: 84-88

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 下顎前歯部歯肉に生じた疣贅状黄色腫の1例2013

    • Author(s)
      川原田幸司、諏訪若子、諏訪裕彦、平野真人、江原道子、永山元彦、村木智則、谷口敬裕、   江原雄一、式守道夫、田沼順一.
    • Journal Title

      岐阜歯科学会雑誌

      Volume: 40(2) Pages: 155-158

    • NAID

      110009808439

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 下顎骨に生じた粘液線維腫の1例2013

    • Author(s)
      諏訪裕彦、川原田幸司、厚地攻誠、田中四郎、式守道夫、永山元彦、田沼順一.
    • Journal Title

      岐阜歯科学会雑誌

      Volume: 40(2) Pages: 159-163

    • NAID

      110009827538

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of sinonasal undifferentiated carcinoma treated with chemoradiation therapy.2013

    • Author(s)
      Ohta K, Sumitomo S, Nagyama M, Tanuma J, Shikimori M.
    • Journal Title

      Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

      Volume: 0 Issue: 2 Pages: 0-0

    • DOI

      10.1016/j.ajoms.2013.10.001

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intraneural perineurioma arising in the lateral border of the tongue.2013

    • Author(s)
      Hirano M, Muraki M, Nagayama M, Ehara M, Kawarada K, Suwa H, Kitano M, Tanuma J.
    • Journal Title

      Pathology International

      Volume: 63(12) Issue: 12 Pages: 619-621

    • DOI

      10.1111/pin.12121

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pthlh, a promising cancer modifier gene in rat tongue carcinogenesis2013

    • Author(s)
      Hirohiko Suwa, Jun-ichi Tanuma1, Masato Hirano, Motohiko Nagayama, Michiko Ehara, Tomonari Muraki, Hayase Shisa, Aiko Sugiyama, Masahiro Sugimoto, Hiroshi Hiai, Motoo Kitano.
    • Journal Title

      Cancer Science

      Volume: 104 Pages: 1-10

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 歯原性線維種を疑わせた歯原性粘液腫の1例2012

    • Author(s)
      田中四郎、住友伸一郎、江原雄一、太田貴久、村木智則、永山元彦、式守道夫、田沼順一
    • Journal Title

      岐阜歯科学会雑誌

      Volume: 39(1) Pages: 16-20

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 口腔粘膜上皮擦過細胞診における従来法とLBC法との比較2014

    • Author(s)
      江原道子、永山元彦、住友伸一郎、川原田幸司、田沼順一
    • Organizer
      第53回日本臨床細胞学会秋期総会
    • Place of Presentation
      下関
    • Year and Date
      2014-11-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] 舌癌モデル動物を用いた発癌のメカニズムの解明2014

    • Author(s)
      田沼順一
    • Organizer
      松本歯科大学大学院歯学研究科セミナー
    • Place of Presentation
      松本歯科大学
    • Year and Date
      2014-10-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 口腔前癌病変診断マーカーとしての糖鎖の可能性2014

    • Author(s)
      江原道子、中尾寿奈、永山元彦、田沼順一
    • Organizer
      第56回日本歯科基礎学会総会
    • Place of Presentation
      博多
    • Year and Date
      2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 教育講演 口腔癌の細胞像 ;非腫陽性病変との鑑別-2014

    • Author(s)
      田沼順一
    • Organizer
      第52回日本臨床細胞学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-06-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] hnRNP K is a new prospective marker of early detection for tongue carcinogenesis.2014

    • Author(s)
      Tanuma J, Ehara M, Nagayma M.
    • Organizer
      17th International Congress of Oral Pathology and Medicine.
    • Place of Presentation
      Istanbul, Turkey
    • Year and Date
      2014-05-25 – 2014-05-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] hnRNP K is a new prospective marker of early detection for tongue carcinogenesis2014

    • Author(s)
      田沼順一、中尾寿奈、江原道子、永山元彦、志佐湍、日合弘、北野元生
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島
    • Year and Date
      2014-04-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Advances and applications of oral cancer basic research2014

    • Author(s)
      Tanuma J.
    • Organizer
      2nd International Symposium of Oral Health and Disease
    • Place of Presentation
      UAEM, Mexcio
    • Year and Date
      2014-04-07 – 2014-04-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Pthlh,a cancer modifier gene in rat tongue carcinogenesis.2013

    • Author(s)
      諏訪宏彦、平野真人、永山元彦、江原道子、志佐湍、日合弘、北野元生、田沼順一
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] 軟骨石灰化不全ラット(CCIラット)における頭蓋底成長の形態学的観察2013

    • Author(s)
      永山元彦、江原道子、平野真人、田沼順一
    • Organizer
      第24回日本臨床口腔病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] インディアンヘッジホッグシグナル阻害による歯周組織への影響2013

    • Author(s)
      安部雅世、渡邉昌弘、安田忠司、永山元彦、田沼順一、渋谷俊昭
    • Organizer
      第56回日本歯周病学会総会
    • Place of Presentation
      前橋
    • Related Report
      2013 Research-status Report
  • [Presentation] 頬粘膜に生じた粘表皮癌の1例2013

    • Author(s)
      永山元彦、太田貴久、江原道子、式守道夫、田沼順一
    • Organizer
      第23回日本口腔内科学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 広範な下顎骨吸収を伴うオトガイ下部のリンパ管腫の1例2013

    • Author(s)
      永山元彦、松原 誠、江原道子、村松泰徳、式守道夫、田沼順一
    • Organizer
      第23回日本口腔内科学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] FGF2と骨代用材としてリン酸カルシウムを基材とした生体内における相乗効果2013

    • Author(s)
      門中貴義、江原道子、中島宗則、田沼順一、永原國央
    • Organizer
      第43日本口腔インプラント学会学術総会
    • Place of Presentation
      博多
    • Related Report
      2013 Research-status Report
  • [Presentation] 軟骨石灰化不全ラット(CCIラット)に置ける頭蓋底軟骨結合部の形態学的解析2013

    • Author(s)
      竹内 綾、永山元彦、葛島康平、渡部博之、江原道子、天野 均、田中政巳、渡辺 実、田沼順一、北井則行
    • Organizer
      第55回歯科基礎医学会総会•学術大会
    • Place of Presentation
      岡山
    • Related Report
      2013 Research-status Report
  • [Presentation] Analyzed the expression of hnRNP K in the human oral carcinogenesis2013

    • Author(s)
      村木智則、平野真人、式守道夫、江原道子、永山元彦、志佐湍、日合弘、北野元生、田沼順一
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] Implications for the diagnostic markers for oral precancerous lesions using sugar chains Expression2013

    • Author(s)
      江原道子、永山元彦、村木智則、田沼順一
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] ヒト口腔前癌病変におけるhnRNP K 発現解析2013

    • Author(s)
      村木智則、平野真人、永山元彦、田沼順一、笠井唯克、式守道夫
    • Organizer
      第58回日本口腔外科学会総会
    • Place of Presentation
      博多
    • Related Report
      2013 Research-status Report
  • [Presentation] 上唇に生じたGlomangiomyomaの1例2013

    • Author(s)
      太田貴久、本橋征之、永山元彦、村松泰徳,住友伸一郎,田沼順一,式守道夫
    • Organizer
      第31回日本口腔腫瘍学会総会
    • Place of Presentation
      秋葉原
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Pthlh, a promising cancer modifier gene in rat tongue carcinogenesis2013

    • Author(s)
      諏訪裕彦、平野真人、村木智則、江原道子、永山元彦、志佐湍、日合弘、北野元生、田沼順一
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] hnRNPK is associated with pre-malignancy in the tongue carcinogenesis2012

    • Author(s)
      村木智則、式守道夫、江原道子、永山元彦、志佐湍、日合弘、北野元生、田沼順一
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京 新宿
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] A case of upper lip tumor2012

    • Author(s)
      永山元彦、太田貴久、江原道子、住友伸一郎、平野真人、田沼順一
    • Organizer
      第23回日本臨床口腔病理学会
    • Place of Presentation
      東京 お茶の水
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] hnRNPK is associated with pre-malignancy in the tongue carcinogenesis2012

    • Author(s)
      平野真人、村木智則、江原道子、永山元彦、志佐湍、日合弘、北野元生、田沼順一
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 角化嚢胞性歯原性腫瘍の2例2012

    • Author(s)
      江原道子、村木智則、太田貴久、田中四郎、住友伸一郎、平野真人、永山元彦、田沼順一
    • Organizer
      第51回日本臨床細胞学会総会
    • Place of Presentation
      新潟
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] わかりやすい病理学2015

    • Author(s)
      恒吉正澄、小田義直、田沼順一
    • Publisher
      南江堂
    • Related Report
      2014 Annual Research Report
  • [Remarks] 朝日大学歯学部口腔病理学分野

    • URL

      http://scw.asahi-u.ac.jp/~patho/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 朝日大学歯学部口腔病態医療学講座口腔病理学分野

    • URL

      http://scw.asahi-u.ac.jp/~patho/

    • Related Report
      2013 Research-status Report
  • [Remarks] 朝日大学歯学部口腔病態医療学講座口腔病理学分野

    • URL

      http://scw.asahi-u.ac.jp/~patho/

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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