| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
IL-17 plays essential roles in regulating inflammation and host defense. Natural killer (NK) cells play a key role in inflammation and tumor regression. However, the IL-17 function to NK cells remains incompletely understood. In this stydy, we showed that IL-17 stimulation suppressed the cytotoxicity against target cells (K562 cells) on NK92 cells (human NK cell line). When NK92 cells were stimulated in the absence of IL-17, p38 was constitutively phosphorylated. However, in the presence of IL-17 the phosphorylation of p38 was significantly reduced compared with absence of IL-17. These results suggest that IL-17 stimulation on NK92 cells suppressed the cytotoxicity and that suppression was involved in a phosphorylation of p38.
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